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ICAM-1 and VCAM-1. Clinical and histological results were
evaluated by three observers.
Results: Evaluation after PDL treatment showed a significant
reduction of the dermal lymphocytic infiltrate in 6/9 patients
(66.66%) as well as an important reduction of the basal damage in
6/7 patients (85.71%). Other epidermal changes improved in 4/6
patients (66.66%). Mucin deposition persisted only in two
patients. ICAM and VCAM expression was reduced in 7/7 patients
(100%) and 5/6 patients (83.33%) (P < 0.05). Clinical
improvement was present in 8/9 patients (88.88%) without side
effects.
Conclusion: PDL therapy is an effective treatment for CLE.
The selective destruction of vessels and the immunomodulatory
effect could be the main mechanisms of action. Downregulation
of ECAMs could also have influence on the treatment
response.
#264
American Society for Laser Medicine and Surgery Abstracts 79
#265
EFFICACY OF A NOVEL NON-HYDROQUINONE
FORMULATION IN THE TREATMENT OF
MELASMA: A REFLECTANCE CONFOCAL
MICROSCOPE STUDY
Katerina Tsilika, Jean-Luc Levy, Hee-Yang Kang,
Luc Duteil, Abdallah Khemis, Thierry Passeron,
Jean-Paul Ortonne, Philippe Bahadoran
CHU of Nice, Nice, France; Center of Dermatological Lasers,
Marseille, France; Suwon, Korea
Background: Melasma is a frequent and disabling pigmentary
disorder. Available treatments are still unsatisfactory.
Reflectance confocal microscopy (RCM) is a new imaging
technique that detects pigment changes at a cellular level. In this
study, we evaluated the clinical efficacy and tolerance of a novel
non-hydroquinone formulation, Dermamelan 1 (Mesoestetic,
Barcelona, Spain), in the treatment of melasma, and we used
RCM to monitor pigment changes at the cellular level.
Study: Ten subjects with Fitzpatrick skin types II–IV and facial
melasma were recruited for this open label study. Patients applied
Dermamelan 1 (azelaic acid, kojic acid, alpha arbutin, glycirriza
glabra extract and ascorbic acid) once daily during 12 weeks. Each
visit (week 0, week 4, week 8, week 12, week 12 þ 4) included
clinical examination, MASI score, standard and UV-light
photographs and RCM examination. Adverse events were also
assessed. RCM images of the epidermis and superficial dermis
were acquired by means of a Vivascope 1500 microscope (Lucid,
Inc., Rochester, NY, USA).
Results: Before treatment the mean MASI score was 22. RCM
detected hyperpigmented keratinocytes in all lesions, activated
melanocytes in 2/10 lesions, and dermal melanophages in 2/10
lesions. After completion of treatment, the MASI decreased to 11
(P ¼ 0.008). The decrease of MASI was reached after 1 month of
treatment and was maintained until 1 month after the end of it.
These results were confirmed by standard and UV-light
photographs. In parallel to clinical improvement, RCM showed a
statistically significant decrease of hyperpigmented keratinocytes
(P ¼ 0.02). Noticingly, patients with dermal melanophages on
RCM at baseline had only a limited response and melanophages
persisted on RCM follow-up. Mild irritation was the only adverse
event observed.
Conclusion: In this pilot study of Dermamelan 1 in melasma, we
observed a good outcome in most patients. We also demonstrated
the interest of RCM to monitor and possibly predict treatment
efficacy of a novel depigmenting agent in melasma.
CO2 LASER RESURFACING: A 15-YEAR
EXPERIENCE
Samir Undavia, Russell Kridel
University of Texas Health Science Center, Houston, TX
Background: To review our experience with CO2 laser
resurfacing in patients with fine rhytids and other cutaneous
textural problems, poorly healed scars, and actinic-related skin
conditions.
Study: A retrospective chart review of all patients who
underwent CO2 laser resurfacing by the senior author from 1995
to 2010. Adjunctive procedures do not exclude patients from the
study.
Intervention: Ultrapulse 5000C Computer Pattern Generated
Carbon Dioxide Laser with a CPG (computer generated hand
piece) (Coherent Laser Corporation, Palo Alto, CA) and later the
upgraded model, the Encore Plus Carbon Dioxide Laser with CPG
and later fractionated hand pieces (Lumenis Corporation, which
purchased Coherent Corporation).
Main Outcome Measure(s): Indications, treatment protocols,
follow-up care, patient demographics and skin types, mean followup
time, adjunctive procedures, complications, timing of
complications, treatment of complications, setting of treatments,
patients satisfaction surveys, and grading of pre- and long-term
post-treatment photographs by a panel of blinded facial plastic
surgery reviewers using a standardized facial rhytids scale will be
reported.
#266
A NOVEL THERAPY FOR EFFECTIVE CELLULITE
TREATMENT IN WOMEN
Elizabeth VanderVeer, Carrie Anderson
VanderVeer Center, Portland, OR
Background: Cellulite, a common disorder on the buttocks and
thighs of women, is caused by the herniation of subcutaneous fat
within fibrous connective tissue. Cellulite is difficult to treat and
most FDA-approved devices lack significant efficacy. This study
assessed a six-treatment protocol for the treatment of cellulite
over three weeks using a novel Acoustic Wave Technology (AWT)
Device. The study evaluated whether this novel technology was
safe; tolerable by the patient; and effective with long-lasting
results.
Study: A total of five adult women received treatment to their
bilateral buttock and posterior thigh region. The average patient
age was 46 with an average BMI of 22. Patients did not alter their
lifestyle and maintained their normal daily activities without any
side effects or downtime. Six 30-minute treatments were
administered to the treatment area using AWT via a hand piece
with a 15 mm applicator tip. Ultrasound gel was used to apply
2,000 Acoustic Wave ‘‘pulses’’ in a circular motion to each
20 20 cm 2 area. An average total of 8,000 pulses were
administered per patient per-treatment session. The delivery
frequency (Hz) and energy level (Bar) were increased as tolerated
during each session until the maximum therapeutic ‘‘dose’’ of
4 Bar and 18 Hz could be achieved.
Results: All five patients completed treatment. Photographic
assessment and cellulite grade was assigned to each patient by
two blinded observers before treatment and at 4 and 12 weeks
post-treatment protocol. No adverse events were reported.
Treatment was described as uncomfortable, but tolerable by all
patients. Significant improvement was noted with an average of