Presidential Greeting - American Society for Laser Medicine and ...

44 American Society for Laser Medicine and Surgery Abstracts
Background: The 1,540 nm laser is the first and only fractional
ablative handpiece to receive FDA clearance for the treatment of
striae. We evaluate the effect of density and depth of treatment
using the 1,540 and 1,440 nm handpieces, and three different
optics.
Study: Bilateral treatments were performed on thigh striae.
Striae were trisected and treated with the 1,440 or 1,540 nm
handpiece and the 10 mm (70 mJ, 100 mb/cm 2 ), 15 mm (10 mJ,
320 mb/cm 2 ) or XD optic (70 mJ, 25 mb/cm 2 ). Baseline and 3month
histology was performed on two subjects receiving
1,540 nm treatment. One subject received a single high-coverage
treatment and a second subject received three treatments at
6-week intervals. Hematoxylin and eosin staining (H&E) and
elastin immunohistochemistry were performed on serial sections.
Clinical assessments using a quartile improvement scale (Grades
I to IV) and subject self-assessment data were collected from 20
subjects treated with the 1,540 nm handpiece.
Results: Treatments were well-tolerated yielding only trace
erythema and transient hyperpigmentation in two subjects which
resolved. Optimal results, including significant restoration of
natural color to striae alba and a reduction in palpable depression,
were obtained using the 15 mm optic for the first treatment
followed by the 10 mm optic for the remaining treatments. One
hundred percent of patients showed improvement, ranging from
Grade II to Grade III. Histology demonstrates remodeling of
collagen and elastin fibers.
Conclusion: The 1,540 and 1,440 nm handpieces can be used to
safely and effectively treat a wide variety of striae over a wide
range of skin types. A strategy combining remodeling of the upper
and deeper dermis using different optics was beneficial for
optimizing treatment of striae.
#140
CLINICAL EFFICACY OF FRACTIONAL ERBIUM
FIBER 1,410 NM LASER FOR TREATMENT OF
DILATED PORES IN KOREANS
JeeYoung Park, SangJun Lee, JiHo Rho,
KyeYong Song
Arundaunnara Dermatologic Clinic; Chung-ang University,
Seoul, Korea
Background: Skin pores are openings of the pilosebaceous units
and increased sebum production and decreased skin laxity are
considered to be two major causes of dilated pores. Dilated skin
pores are cosmetic concerns in many people and various
treatments have been tried but current treatments have shown
limited efficacy. We evaluate clinical efficacy of 1,410 nm
fractional erbium fiber laser for treatment of dilated pores.
Study: Total 38 patients with dilated pores were enrolled in this
study. Patients are divided into two groups according to degree of
sebum secretion. Both group patients received three sessions
treatment at 3–4 weeks intervals and followed-up for 6 months.
Clinical efficacy was evaluated with photographic evaluation by
physician and satisfaction evaluation by patients at 3 months and
6 months after last laser treatment. Histologic examination from
three patients were performed at baseline and at 2 months after
last laser treatment.
Results: Twenty-eight patients were in group 1 (dilated pores
without active sebum secretion) and ten patients were in group 2
(dilated pores with active sebum secretion and acne). Treatment
was well-tolerated in all patients and there was no serious
complication. At evaluation of 3 months after treatment, group 1
showed 78% and group 2 showed 67% clinical improvement in
average. At evaluation of 6 months after treatment, group 1
showed 75% and group 2 showed 60% clinical improvements. In
evaluation of satisfaction by patients, group 1 showed higher
satisfaction degree than group 2 in both 3 and 6 months’
evaluation. On histology, increased collagen production of upper
dermis was observed in all three patients.
Conclusion: Fractional Erbium doped 1,410 nm laser resurfacing
could be one of effective and safe treatment modalities for dilated
pores in Asians. Especially, dilated pores patients with less sebum
secretion showed better and longer clinical efficacy and high
satisfaction degree in this study.
PHOTOBIOMODULATION
#145
NEW TECHNIQUE FOR DELIVERING LASER
ENERGY DEEPER INTO TISSUE
Sean Wang, Qun Li, Kerith Wang
B&W TEK, Inc., Newark, DE
Background: In laser therapy, it is necessary to effectively
deliver a required level of laser energy deep into tissues for
treatment of acute stroke, spinal cord nerve regeneration, PDT for
certain deeply embedded cancers, etc. However, biological tissue
is an optically inhomogeneous and highly scattering media in
additional to wavelength selective absorption. The depth of
penetration is severely limited due to strong diffractive scattering/
reflection/trans-refraction of the cells with their physical
dimensions on the order of micrometers, which is within the
strong optical diffractive regions of visible/NIR light.
Study: In this paper, we will discuss and explore several novel
techniques, such as multi-beam coherent mixing, non-diffracting
beam conversion which can effectively increase and control the
depth of laser beam penetration into tissues.
Results: Experimental demonstrations will also be presented.
Conclusion: These novel approaches will further advance the
effectiveness of applying laser bio-modulation in a real clinical
environment.
#147
EFFECTS OF VEGF MIMICKING PEPTIDES AND
PHOTORADIATION ON WOUND HEALING IN A
MURINE PRESSURE ULCER MODEL
Raymond Lanzafame, Istvan Stadler
Rochester General Hospital, Rochester, NY
Background: Chronic wounds are a growing problem. The
activity of VEGF mimetic peptides and phototherapy were
evaluated in an animal pressure ulcer model.
Study: Pressure ulcers were created (J Invest Surg, 17:221–227;
2004) on nine groups of Balb/C mice (n ¼ 10). Photoradiation at
670 nm (LLLT) was administered daily for 18 days post-ulcer
creation, delivered in two 2.5 J/cm 2 fractions/day at
40 mW 62.5 seconds using LED arrays (Quantum Devices,
Barneveld, WI). The ulcers were covered with Tegaderm TM
dressings. Two peptides (P1, P2) at 0.01 mg, two scrambled
peptides (S1, S2), or vehicle (V) alone were applied in saline 2 /