rok 2007 - Fakulta chemickej a potravinárskej technológie
rok 2007 - Fakulta chemickej a potravinárskej technológie
rok 2007 - Fakulta chemickej a potravinárskej technológie
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VEGA project No 1/2469/05 Study of stereoselective transformations of non proteinogenic<br />
oxoaminocarboxylic acids (Dušan Berkeš)<br />
Synthesis of enantiomerically pure, conformationally restricted derivatives of homophenylalanine and of its<br />
heteroanalogs by crystallization induced asymmetric transformation (CIAT) coupled with the aza-Michael addition<br />
and electrophilic lactonization. Study of simultaneous CIAT taking place at two stereogenic centers. Synthesis<br />
and stereoselective transformations of bicyclic tetramic acid derivatives. Utilization of such asymmetric<br />
transformation in the synthesis of natural polysubstituted amino acids and their derivatives. Preparation of 5<br />
aryl¬substituted 3 amino-2-hydroxytetrahydrofurans and study of their conversion to optically pure substituted C-<br />
aryl amino¬furanosides.<br />
Project duration: from 01.01.2005 to 31.12.<strong>2007</strong><br />
VEGA project No 1/248/05 Polyazaheterocycles and their oxygen analogues. Ecologically<br />
more suitable syntheses, supramolecular structure, biological – physical properties (Viktor<br />
Milata)<br />
The project aims at preparation of novel aromatic polyazaheterocycles on the bases of triazines, dihydropyridines,<br />
pyrimidines, quinolines and quinazolines, having additional fused aromatic or saturated ring. In the early stages of<br />
the project we shall concentrate on preparation of precursors to the above heterocycles by modern, more<br />
ecological methods. Next the precursors will be used in cyclization and cyclocondensation reaction leading to<br />
target compounds. Prepared heterocycles will be modified to enhance their hydrophilicity and hence bioactivity by<br />
attaching a sugar or other hydrophilic moiety. Our attention will concentrate on physicochemical and spectral<br />
characteristics, combined with xray analysis, supramolecular chemistry and quantum chemical calculations.<br />
Project duration: from 01.01.2005 to 31.12.<strong>2007</strong><br />
APVV Project No. 20-007304 Synthesis and properties of the pharmacologically potentially<br />
active nitrogen heterocycles (Viktor Milata)<br />
Study and optimisation of the new synthetic methods for preparation of analogues of natural condensed aromatic<br />
polyazaheterocyclic compounds with fused aromatic or saturated ring containing O, S, Se or N atoms.<br />
Preparation of precursors of cited heterocycles and their nitro- and aminoderivatives, imidoylchlorides, imidoyl<br />
and amidinoylisothiocyanates. Exploitation of new precursors in cyclisation and cyclocondesation reactions for<br />
preparation of target compounds. Derivatisation of newly prepared heterocyclic compounds by introduction of<br />
carbohydrate or other hydrophylic part aiming to higher solubility of prepared compounds allowing their more<br />
effective biological application. Study of physico-chemical properties and spectral characteristics of final<br />
derivatives in relation to their X-ray structural analysis, supramolecular chemistry using quantum-chemical<br />
calculations.<br />
Project duration: from 01.01.2005 to 31.12.<strong>2007</strong><br />
APVT Project No. 20-000904 Asymmetric Pd(II)-catalysed reactions as a methodology for the<br />
preparation of chiral bulding blocks for the synthesis of biologically active natural<br />
compounds (Peter Szolcsányi)<br />
The main aim of the project is to develop a new and efficient methodology of asymmetric palladium-catalysed<br />
intramolecular and intermolecular aminocarbonylations and halocyclisations for the enantioselective preparation<br />
of optically pure building blocks. These valuable intermediates will serve as suitable chiral precursors for targeted<br />
total syntheses of biologically active natural compounds and/or their analogues with their potential use in human<br />
medicine. The sub-objectives of the project involve the development of a simple and rapid preparation of<br />
necessary aminoalkenitols as starting substrates in multi-gram quantities and required purity, as well as an<br />
effective synthesis of enantiomerically pure chiral Pd-catalysts essential for key asymmetric transformations.<br />
Project duration: from 01.01.2005 to 31.12.<strong>2007</strong><br />
VI. COOPERATION<br />
A. Cooperation in Slovakia<br />
Institution Type of cooperation Responsible person Duration<br />
168