Section Days abstract book 2010.indd - RUB Research School ...

LS_9
ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN
AUTOIMMUNE INFLAMMATION OF THE CENTRAL
NERVOUS SYSTEM
A.Manzel 1,2 , D. Lee 2 , J. Stegbauer 3 , S. Seubert 2 , G. Ellrichmann 2 , S. Gaupp 2 , L. C.
Rump 3 , R. Gold 1,2 , R. A. Linker 2
1 International Graduate School of Neuroscience, Ruhr University Bochum, Universitätsstr.
150, D-44780 Bochum, Germany; 2 Department of Neurology St.-Josef Hospital, Ruhr
University Bochum, 3 Department of Nephrology, Heinrich-Heine-University Dusseldorf,
Germany
e-mail: arndt.manzel@t-online.de
Angiotensin II (AngII), the principal messenger molecule of the renin-angiotensin system
(RAS) regulates blood pressure and fluid balance mainly by acting on AT1 receptors. The
RAS may play a role in the development of hypertension and atherosclerosis, where T-cell
and macrophage mediated inflammation are important disease mechanisms [1,2]. Here our
group investigated the role of the RAS in murine experimental autoimmune
encephalomyelitis (EAE) [3], a model mimicking many aspects of human multiple sclerosis.
We found that blockade of AT1 receptors ameliorates EAE and impairs macrophage motility.
References
[1] Guzik TJ, et al. (2007) J Exp Med 204:2449–2460
[2]Combadiere C, et al. (2008) Circulation 117:1649–1657
[3] Stegbauer J, et al. (2009) PNAS 106(35):14942-7