Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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CHAPTER 2 Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration Sofía Sánchez-Iglesias,* Ramón Soto-Otero,* Javier Iglesias-González,* M. Carmen Barciela-Alonso,† Pilar Bermejo-Barrera† and Estefanía Méndez-Álvarez* *Laboratory of Neurochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain †Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela, Santiago de Compostela, Spain J. Trace Elem. Med. Biol. (2007) 21, S1, 31–34. 103
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
Page 75 and 76: INTRODUCTION induce selective DAerg
Page 77 and 78: ALUMINIUM General features INTRODUC
Page 79 and 80: INTRODUCTION Varying amounts of alu
Page 81 and 82: INTRODUCTION and antiperspirants co
Page 83 and 84: INTRODUCTION approximately 3% of al
Page 85 and 86: Excretion INTRODUCTION As insoluble
Page 87 and 88: INTRODUCTION 3.5 mg may be increase
Page 89 and 90: INTRODUCTION Oteiza 1999), non-iron
Page 91 and 92: Aluminium as a cell membrane menace
Page 93 and 94: INTRODUCTION mobilization of Ca 2+
Page 95: Aluminium impairs neurotransmission
Page 99 and 100: AIMS OF THE PRESENT THESIS The main
Page 101: OBJETIVOS
Page 104 and 105: OBJETIVOS 3) Evaluar de forma preci
Page 107: CHAPTER 1 Time-course of brain oxid
Page 110 and 111: CHAPTER 1 INTRODUCTION 86 6-OHDA (2
Page 112 and 113: CHAPTER 1 MATERIALS AND METHODS Che
Page 114 and 115: CHAPTER 1 followed by centrifugatio
Page 116 and 117: CHAPTER 1 RESULTS Effects of 6-OHDA
Page 118 and 119: CHAPTER 1 DISCUSSION 94 As shown by
Page 120 and 121: CHAPTER 1 strategies or to study th
Page 122 and 123: CHAPTER 1 Fig. 2 Changes in PCC in
Page 125: CHAPTER 2
Page 130 and 131: CHAPTER 2 INTRODUCTION 106 Aluminiu
Page 132 and 133: CHAPTER 2 experimental period of fo
Page 134 and 135: CHAPTER 2 RESULTS Aluminium distrib
Page 136 and 137: CHAPTER 2 significant increase of t
Page 139: CHAPTER 3
Page 143 and 144: ABSTRACT CHAPTER 3 The ability of a
Page 145 and 146: CHAPTER 3 not undergo redox reactio
Page 147 and 148: CHAPTER 3 saline over the same peri
Page 149 and 150: CHAPTER 3 used as chemical dosimete
Page 151 and 152: Statistical analysis CHAPTER 3 Data
Page 153 and 154: CHAPTER 3 was noted in hippocampus
Page 155 and 156: CHAPTER 3 In vitro effects of alumi
Page 157 and 158: CHAPTER 3 administration routes (De
Page 159 and 160: CHAPTER 3 difference in the levels
Page 161 and 162: CHAPTER 3 Table 1. In vitro effects
Page 163 and 164: CHAPTER 3 139
Page 167 and 168: CHAPTER 3 Fig. 4 Density of striata
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Page 175 and 176: SUMMARY SUMMARY Aluminium has becom
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SUMMARY stress is reached at this t
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CONCLUSIONS
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CONCLUSIONS 5) Intraperitoneal alum
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RESUMEN
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RESUMEN 1996, Shimohama et al. 2003
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RESUMEN 166 Por último y con el fi
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CONCLUSIONES CONCLUSIONES Los resul
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CONCLUSIONES aumento de grupos carb
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APPENDIX
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APPENDIX Publications arising from
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REFERENCES REFERENCES Aarts M., Liu
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