Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

More documents

Recommendations

Info

CHAPTER 3 Fig. 5 Levels of TBARS (A), protein carbonyls (B), and protein thiols (C) in both ventral midbrain and striatum of different groups of rats: control, i.p. treated with saline for 10 days and injected intraventricularly with saline; control+Al, i.p. treated with aluminium for 10 days and injected intraventricularly with saline; 6-OHDA, i.p. treated with saline for 10 days and lesioned with 6-OHDA on the 8th day; and finally 6- OHDA+Al, i.p. treated with aluminium for 10 days and lesioned on the 8th day with 6- OHDA. Doses used: aluminium (10 mg Al 3+ /kg/day), 6-OHDA (200 µg). Abbreviation: Al, aluminium. Rats were sacrificed two days after lesioning. Data are expressed as means ± SD from five rats (n = 5). Significance of differences among groups was assessed by a one-way ANOVA followed by a Bonferroni‟s test. Asterisks, pads and section sign denote values significantly different from the corresponding controls: control, control+Al, 6-OHDA respectively (*, # , § , p < 0.05; **, # # , §§ , p < 0.01; *** p < 0.001). 144
CHAPTER 3 145
Page 1:
Universidade de Santiago de Compost
Page 5:
Don Ramón Soto Otero y Doña Estef
Page 9 and 10:
Acknowledgements The work of this t
Page 11 and 12:
Abbreviations AA ascorbic acid AD A
Page 13:
Abbreviations (continuation) PCC pr
Page 16 and 17:
List of figures (continuation) Chap
Page 19 and 20:
TABLE OF CONTENTS INTRODUCTION ....
Page 21:
CHAPTER 3 Brain oxidative stress an
Page 25 and 26:
INTRODUCTION PARKINSON’S DISEASE
Page 27 and 28:
INTRODUCTION PD is found in all eth
Page 29 and 30:
Bradykinesia INTRODUCTION Bradykine
Page 31 and 32:
INTRODUCTION predate the occurrence
Page 33 and 34:
Table 1: Differential diagnostic in
Page 35 and 36:
INTRODUCTION Table 3: National Inst
Page 37 and 38:
Figure 4: Dopamine catabolism (Mén
Page 39 and 40:
The basal ganglia INTRODUCTION The
Page 41 and 42:
The death of SNpc DAergic neurons I
Page 43 and 44:
INTRODUCTION the dorsomedial part o
Page 45 and 46:
INTRODUCTION characterized as are l
Page 47 and 48:
INTRODUCTION (Olanow et al. 2004).
Page 49 and 50:
Etiology and pathogenesis of PD INT
Page 51 and 52:
Ageing INTRODUCTION Ageing remains
Page 53 and 54:
INTRODUCTION The finding of MPTP to
Page 55 and 56:
INTRODUCTION may clarify why many n
Page 57 and 58:
Misfolding and aggregation of prote
Page 59 and 60:
INTRODUCTION (E3) (Figure 18A). Los
Page 61 and 62:
INTRODUCTION in connection with Par
Page 63 and 64:
INTRODUCTION Oxidative damage happe
Page 65 and 66:
DA metabolism as a source of ROS IN
Page 67 and 68:
Contribution of oxidative and nitro
Page 69 and 70:
Excitotoxicity INTRODUCTION Glutama
Page 71 and 72:
INTRODUCTION al. 1996, Cicchetti et
Page 73 and 74:
Experimental models of PD INTRODUCT
Page 75 and 76:
INTRODUCTION induce selective DAerg
Page 77 and 78:
ALUMINIUM General features INTRODUC
Page 79 and 80:
INTRODUCTION Varying amounts of alu
Page 81 and 82:
INTRODUCTION and antiperspirants co
Page 83 and 84:
INTRODUCTION approximately 3% of al
Page 85 and 86:
Excretion INTRODUCTION As insoluble
Page 87 and 88:
INTRODUCTION 3.5 mg may be increase
Page 89 and 90:
INTRODUCTION Oteiza 1999), non-iron
Page 91 and 92:
Aluminium as a cell membrane menace
Page 93 and 94:
INTRODUCTION mobilization of Ca 2+
Page 95:
Aluminium impairs neurotransmission
Page 99 and 100:
AIMS OF THE PRESENT THESIS The main
Page 101:
OBJETIVOS
Page 104 and 105:
OBJETIVOS 3) Evaluar de forma preci
Page 107:
CHAPTER 1 Time-course of brain oxid
Page 110 and 111:
CHAPTER 1 INTRODUCTION 86 6-OHDA (2
Page 112 and 113:
CHAPTER 1 MATERIALS AND METHODS Che
Page 114 and 115:
CHAPTER 1 followed by centrifugatio
Page 116 and 117:
CHAPTER 1 RESULTS Effects of 6-OHDA
Page 118 and 119: CHAPTER 1 DISCUSSION 94 As shown by
Page 120 and 121: CHAPTER 1 strategies or to study th
Page 122 and 123: CHAPTER 1 Fig. 2 Changes in PCC in
Page 125: CHAPTER 2
Page 129 and 130: ABSTRACT CHAPTER 2 In the present w
Page 131 and 132: MATERIALS AND METHODS Chemicals CHA
Page 133 and 134: CHAPTER 2 atomization used were 1,5
Page 135 and 136: DISCUSSION CHAPTER 2 Aluminium ente
Page 137: Table 1. Graphite furnace programme
Page 141: CHAPTER 3 Brain oxidative stress an
Page 144 and 145: CHAPTER 3 INTRODUCTION 120 The huma
Page 146 and 147: CHAPTER 3 MATERIALS AND METHODS Che
Page 148 and 149: CHAPTER 3 1:15 for hippocampus and
Page 150 and 151: CHAPTER 3 initially incorporated to
Page 152 and 153: CHAPTER 3 RESULTS In vivo effects o
Page 154 and 155: CHAPTER 3 Effects of aluminium admi
Page 156 and 157: CHAPTER 3 DISCUSSION 132 Aluminium
Page 158 and 159: CHAPTER 3 hippocampus, showed simil
Page 160 and 161: CHAPTER 3 assume that the distinct
Page 162 and 163: CHAPTER 3 Fig. 1 Levels of TBARS (A
Page 164 and 165: CHAPTER 3 Fig. 2 Enzyme activity of
Page 166 and 167: CHAPTER 3 Fig. 3 Microphotographs s
Page 170 and 171: CHAPTER 3 Fig. 6 In vitro effects o
Page 173: SUMMARY
Page 176 and 177: SUMMARY values were attained at 48
Page 178 and 179: SUMMARY neurodegeneration in the DA
Page 181 and 182: CONCLUSIONS The results obtained in
Page 183: 13) Aluminium does affect neither M
Page 187 and 188: RESUMEN RESUMEN Desde el punto de v
Page 189 and 190: RESUMEN zonas cerebrales excepto en
Page 191: CONCLUSIONES
Page 194 and 195: CONCLUSIONES Capítulo 2 4) La admi
Page 196 and 197: CONCLUSIONES 172 En base a las conc
Page 199 and 200: Publications as a direct result fro
Page 201: REFERENCES
Page 204 and 205: REFERENCES Agil A., Duran R., Barre
Page 206 and 207: REFERENCES Baquet Z. C., Bickford P
Page 208 and 209: REFERENCES 184 1,2,3,6-tetrahydropy
Page 210 and 211: REFERENCES 186 compacta of the subs
Page 212 and 213: REFERENCES Chung K. K., Dawson V. L
Page 214 and 215: REFERENCES Davies K. J. (2001) Degr
Page 216 and 217: REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219:
REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221:
REFERENCES Fleming S. M., Delville
Page 222 and 223:
REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225:
REFERENCES Good P. F., Olanow C. W.
Page 226 and 227:
REFERENCES Hamilton E. I., Miniski
Page 228 and 229:
REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231:
REFERENCES Inden M., Kitamura Y., T
Page 232 and 233:
REFERENCES Johnson V. J. and Sharma
Page 234 and 235:
REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237:
REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239:
REFERENCES 214 K.D. and Polymeropou
Page 240 and 241:
REFERENCES Maraganore D. M., Lesnic
Page 242 and 243:
REFERENCES McCord J. M. and Fridovi
Page 244 and 245:
REFERENCES Miu A. C. and Benga O. (
Page 246 and 247:
REFERENCES Nair V. D., McNaught K.,
Page 248 and 249:
REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251:
REFERENCES Perez F. A. and Palmiter
Page 252 and 253:
REFERENCES Przedborski S. and Goldm
Page 254 and 255:
REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257:
REFERENCES Rymar V. V., Sasseville
Page 258 and 259:
REFERENCES Savory J., Herman M. M.
Page 260 and 261:
REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263:
REFERENCES 238 the generation of hy
Page 264 and 265:
REFERENCES Taylor G. A., Moore P. B
Page 266 and 267:
REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269:
REFERENCES Vila M. and Przedborski
Page 270 and 271:
REFERENCES Whitehead M. W., Farrar
Page 272 and 273:
REFERENCES Yokel R. A. (2002a) Alum
Page 274:
REFERENCES Zhou W., Zhu M., Wilson
show all

Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?