Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

List of figures
Introduction
Figure 1 An essay of the shaking palsy 1
Figure 2 The Parkinson’s complex 3
Figure 3 Dopamine synthesis 12
Figure 4 Dopamine catabolism 13
Figure 5 Dopamine pathways 14
Figure 6 Distribution of DA receptors in normal brain 14
Figure 7 The basal ganglia 15
Figure 8 Direct and indirect pathway in normal BG circuits 16
Figure 9 SNpc depigmentation 17
Figure 10 Human brain sections immunostained for DAT 18
Figure 11 Basal ganglia: normal and parkinsonian state 19
Figure 12 LB and LN in PD patients and localization of LB and LN 22
Figure 13 Six stages Braak’s system 24
Figure 14 Immunosections of stages 3-6 of Braak’s system 24
Figure 15 MPTP metabolism 28
Figure 16 The multiple hit model of PD 31
Figure 17 Pathologic mechanisms in the etiology of PD 32
Figure 18 The ubiquitin-proteasome system 34
Figure 19 Generation of ROS and RNS in SNpc neuron 43
Figure 20 Interaction between microglia and DAergic neurons 47
Figure 21 Soluble aluminium ions as a function of solution pH 54
Figure 22 Effects of aluminium and iron on the membrane peroxidation 68
Figure 23 PIP2 hydrolisis altered by aluminium 69
Chapter 1
Figure 1 Changes in TBARS levels in the ipsilateral and contralateral side of
both striatum and ventral midbrain after stereotaxic, unilateral,
intrastriatal injection of 6-OHDA to rats
Figure 2 Changes in PCC in the ipsilateral and contralateral side of both
striatum and ventral midbrain after stereotaxic, unilateral,
intrastriatal injection of 6-OHDA to rats
Figure 3 Changes in PTC in the ipsilateral and contralateral side of both
striatum and ventral midbrain after stereotaxic, unilateral,
intrastriatal injection of 6-OHDA to rats
Chapter 2
Figure 1 Levels of aluminium in the different areas of the rat brain 113
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