Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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REFERENCES Kuhn W., Winkel R., Woitalla D., Meves S., Przuntek H. and Müller T. (1998) High prevalence of 212 parkinsonism after occupational exposure to lead-sulfate batteries. Neurology 50, 1885– 1886. Kumar V. And Gill K. D. (2009) Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch. Toxicol. In press. DOI 10.1007/s00204-009-0455-6. Published online: 01 July 2009. Kurland L. T. (1988) Amylotrophic lateral sclerosis and Parkinson’s disease complex on Guam linked to an environmental neurotoxin. Trends Neurosci. 5, 1151–1158. Kuzuhara S., Mori H., Izumiyama N., Yoshimura M. and Ihara Y. (1988) Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol. 75, 345–353. Lai B. C., Marion S. A., Teschke K. and Tsui J. K. (2002) Occupational and environmental risk factors for Parkinson’s disease. Parkinsonism Relat. Disord. 8, 297–309. Lai B. C., Schulzer M., Marion S., Teschke K. and Tsui J. K. (2003) The prevalence of Parkinson's disease in British Columbia, Canada, estimated by using drug tracer methodology. Parkinsonism Relat. Disord. 9, 233–238. Landrigan, P. J., Sonawane B., Butler R. N., Trasande L., Callan R. and Droller D. (2005) Early environmental origins of neurodegenerative disease in later life. Environ. Health Perspect. 113, 1230–1233. Lane E. and Dunnett S. (2008) Animal models of Parkinson’s disease and L-dopa induced dyskinesia: How close are we to the clinic? Psychopharmacology (Berl). 199, 303–312. Lang A. E. (2007) The progression of Parkinson disease: a hypothesis. Neurology 68, 948–952. Lang A. E. and Lozano A. M. (1998) Parkinson's disease. First of two parts. N. Engl. J. Med. 339, 1044–1053.
REFERENCES Langston J. W. and Ballard Jr. P. A. (1983) Parkinson’s disease in a chemist working with 1- methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N. Engl. J. Med. 309, 310. Langston J. W., Ballard P., Tetrud J. W. and Irwin I. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979–980. Langston J. W., Irwin I., Langston E. B. and Forno L. S. (1984) Pargyline prevents MPTP-induced parkinsonism in primates. Science 225, 1480–1482. Langston J. W., Forno L. S., Tetrud J., Reeves A. G., Kaplan J. A. and Karluk D. (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46, 598–605. Langston J. W. (2006) The Parkinson’s complex: parkinsonism is just the tip of the iceberg. Ann. Neurol. 59, 591–596. Lau Y. S., Trobough K. L., Crampton J. M. and Wilson J. A. (1990) Effects of probenecid on striatal dopamine depletion in acute and longterm 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-treated mice. Gen. Pharmacol. 21, 181–187. LaVoie M. J., Ostaszewski B. L., Weihofen A., Schlossmacher M. G. and Selkoe D. J. (2005) Dopamine covalently modifies and functionally inactivates parkin. Nat. Med. 11, 1214– 1221. Lee C. S., Sauer H. and Björklund A. (1996) Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience 72, 641–653. Lee C. S., Samii A., Sossi V., Ruth T. J., Schulzer M., Holden J. E., Wudel J., Pal P. K., de la Fuente- Fernandez R., Calne D. B. and Stoessl A. J. (2000) In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson’s disease. Ann. Neurol. 47, 493–503. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M. J., Jonnalagada S., Chernova T., Dehejia A., Lavedan C., Gasser T., Steinbach P. J., Wilkinson 213
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
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CHAPTER 3 1:15 for hippocampus and
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CHAPTER 3 initially incorporated to
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CHAPTER 3 RESULTS In vivo effects o
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CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
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CHAPTER 3 Fig. 1 Levels of TBARS (A
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CHAPTER 3 Fig. 2 Enzyme activity of
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CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
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SUMMARY neurodegeneration in the DA
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CONCLUSIONS The results obtained in
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13) Aluminium does affect neither M
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Page 189 and 190: RESUMEN zonas cerebrales excepto en
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Page 194 and 195: CONCLUSIONES Capítulo 2 4) La admi
Page 196 and 197: CONCLUSIONES 172 En base a las conc
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Page 204 and 205: REFERENCES Agil A., Duran R., Barre
Page 206 and 207: REFERENCES Baquet Z. C., Bickford P
Page 208 and 209: REFERENCES 184 1,2,3,6-tetrahydropy
Page 210 and 211: REFERENCES 186 compacta of the subs
Page 212 and 213: REFERENCES Chung K. K., Dawson V. L
Page 214 and 215: REFERENCES Davies K. J. (2001) Degr
Page 216 and 217: REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219: REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221: REFERENCES Fleming S. M., Delville
Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
Page 226 and 227: REFERENCES Hamilton E. I., Miniski
Page 228 and 229: REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
Page 232 and 233: REFERENCES Johnson V. J. and Sharma
Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
Page 242 and 243: REFERENCES McCord J. M. and Fridovi
Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
Page 246 and 247: REFERENCES Nair V. D., McNaught K.,
Page 248 and 249: REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251: REFERENCES Perez F. A. and Palmiter
Page 252 and 253: REFERENCES Przedborski S. and Goldm
Page 254 and 255: REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257: REFERENCES Rymar V. V., Sasseville
Page 258 and 259: REFERENCES Savory J., Herman M. M.
Page 260 and 261: REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263: REFERENCES 238 the generation of hy
Page 264 and 265: REFERENCES Taylor G. A., Moore P. B
Page 266 and 267: REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269: REFERENCES Vila M. and Przedborski
Page 270 and 271: REFERENCES Whitehead M. W., Farrar
Page 272 and 273: REFERENCES Yokel R. A. (2002a) Alum
Page 274: REFERENCES Zhou W., Zhu M., Wilson
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