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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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- Page 152 and 153: CHAPTER 3 RESULTS In vivo effects o
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- Page 156 and 157: CHAPTER 3 DISCUSSION 132 Aluminium
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- Page 162 and 163: CHAPTER 3 Fig. 1 Levels of TBARS (A
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- Page 168 and 169: CHAPTER 3 Fig. 5 Levels of TBARS (A
- Page 170 and 171: CHAPTER 3 Fig. 6 In vitro effects o
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- Page 178 and 179: SUMMARY neurodegeneration in the DA
- Page 181 and 182: CONCLUSIONS The results obtained in
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- Page 187 and 188: RESUMEN RESUMEN Desde el punto de v
- Page 189 and 190: RESUMEN zonas cerebrales excepto en
- Page 191: CONCLUSIONES
- Page 194 and 195: CONCLUSIONES Capítulo 2 4) La admi
- Page 199 and 200: Publications as a direct result fro
- Page 201: REFERENCES
- Page 204 and 205: REFERENCES Agil A., Duran R., Barre
- Page 206 and 207: REFERENCES Baquet Z. C., Bickford P
- Page 208 and 209: REFERENCES 184 1,2,3,6-tetrahydropy
- Page 210 and 211: REFERENCES 186 compacta of the subs
- Page 212 and 213: REFERENCES Chung K. K., Dawson V. L
- Page 214 and 215: REFERENCES Davies K. J. (2001) Degr
- Page 216 and 217: REFERENCES Dhillon A. S., Tarbutton
- Page 218 and 219: REFERENCES Ekstrand M. I., Falkenbe
- Page 220 and 221: REFERENCES Fleming S. M., Delville
- Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
- Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
- Page 226 and 227: REFERENCES Hamilton E. I., Miniski
- Page 228 and 229: REFERENCES Hirsch E. C., Brandel J.
- Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
- Page 232 and 233: REFERENCES Johnson V. J. and Sharma
- Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
- Page 236 and 237: REFERENCES Kuhn W., Winkel R., Woit
- Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
- Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
- Page 242 and 243: REFERENCES McCord J. M. and Fridovi
- Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
- Page 246 and 247:
REFERENCES Nair V. D., McNaught K.,
- Page 248 and 249:
REFERENCES Onyango I. G. (2008) Mit
- Page 250 and 251:
REFERENCES Perez F. A. and Palmiter
- Page 252 and 253:
REFERENCES Przedborski S. and Goldm
- Page 254 and 255:
REFERENCES Rifat S. L., Eastwood M.
- Page 256 and 257:
REFERENCES Rymar V. V., Sasseville
- Page 258 and 259:
REFERENCES Savory J., Herman M. M.
- Page 260 and 261:
REFERENCES Shimizu H., Mori T., Koy
- Page 262 and 263:
REFERENCES 238 the generation of hy
- Page 264 and 265:
REFERENCES Taylor G. A., Moore P. B
- Page 266 and 267:
REFERENCES Um J. W., Stichel-Gunkel
- Page 268 and 269:
REFERENCES Vila M. and Przedborski
- Page 270 and 271:
REFERENCES Whitehead M. W., Farrar
- Page 272 and 273:
REFERENCES Yokel R. A. (2002a) Alum
- Page 274:
REFERENCES Zhou W., Zhu M., Wilson