Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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Publications as a direct result from this thesis APPENDIX Sánchez-Iglesias S., Méndez-Álvarez E., Iglesias-González J., Muñoz-Patiño A., Sánchez-Sellero I., Labandeira-García J. L. and Soto-Otero R. (2009) Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potencial effects in a 6-OHDA-induced model of Parkinson‟s disease. J. Neurochem. 109, 879– 888. PMID: 19425176. Sánchez-Iglesias S., Soto-Otero R., Iglesias-Gónzalez J., Barciela-Alonso M. C., Bermejo-Barrera P. and Méndez-Álvarez E. (2007) Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration. J. Trace Elem. Med. Biol. 21 Suppl. 1, 31–34. PMID: 18039493. Sánchez-Iglesias S., Rey P., Méndez-Álvarez E., Labandeira-García J. L. and Soto- Otero, R. (2007) Time course of brain oxidative damage caused by intrastriatal administration of 6-hydroxydopamine in a rat model of Parkinson‟s disease. Neurochem. Res. 32, 99–105. PMID: 17160721. 175
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
Page 148 and 149: CHAPTER 3 1:15 for hippocampus and
Page 150 and 151: CHAPTER 3 initially incorporated to
Page 152 and 153: CHAPTER 3 RESULTS In vivo effects o
Page 154 and 155: CHAPTER 3 Effects of aluminium admi
Page 156 and 157: CHAPTER 3 DISCUSSION 132 Aluminium
Page 158 and 159: CHAPTER 3 hippocampus, showed simil
Page 160 and 161: CHAPTER 3 assume that the distinct
Page 162 and 163: CHAPTER 3 Fig. 1 Levels of TBARS (A
Page 164 and 165: CHAPTER 3 Fig. 2 Enzyme activity of
Page 166 and 167: CHAPTER 3 Fig. 3 Microphotographs s
Page 168 and 169: CHAPTER 3 Fig. 5 Levels of TBARS (A
Page 170 and 171: CHAPTER 3 Fig. 6 In vitro effects o
Page 173: SUMMARY
Page 176 and 177: SUMMARY values were attained at 48
Page 178 and 179: SUMMARY neurodegeneration in the DA
Page 181 and 182: CONCLUSIONS The results obtained in
Page 183: 13) Aluminium does affect neither M
Page 187 and 188: RESUMEN RESUMEN Desde el punto de v
Page 189 and 190: RESUMEN zonas cerebrales excepto en
Page 191: CONCLUSIONES
Page 194 and 195: CONCLUSIONES Capítulo 2 4) La admi
Page 196 and 197: CONCLUSIONES 172 En base a las conc
Page 200 and 201: APPENDIX Publications arising from
Page 203 and 204: REFERENCES REFERENCES Aarts M., Liu
Page 205 and 206: REFERENCES Andersen J. K. (2004) Ox
Page 207 and 208: REFERENCES Beckman J. S. and Koppen
Page 209 and 210: REFERENCES Bonifati V., Rizzu P., v
Page 211 and 212: REFERENCES Cedarbaum J. M. and McDo
Page 213 and 214: REFERENCES Cooper J. R., Bloom F. E
Page 215 and 216: REFERENCES Deloncle R., Huguet E.,
Page 217 and 218: REFERENCES Döllken U. (1897) Ueber
Page 219 and 220: REFERENCES Exley C. (2004b) Aluminu
Page 221 and 222: REFERENCES (2006) PINK1 protein in
Page 223 and 224: REFERENCES Glinka Y., Tipton K. F.
Page 225 and 226: REFERENCES Grune T., Jung T., Merke
Page 227 and 228: REFERENCES Hegde R., Srinivasula S.
Page 229 and 230: REFERENCES Hughes A. J., Ben-Shlomo
Page 231 and 232: REFERENCES Variable expression of P
Page 233 and 234: REFERENCES Kalaitzakis M. E., Graeb
Page 235 and 236: REFERENCES Klintworth H., Garden G.
Page 237 and 238: REFERENCES Langston J. W. and Balla
Page 239 and 240: REFERENCES Lione A. (1983) The prop
Page 241 and 242: REFERENCES Marti M. J., James C.J.,
Page 243 and 244: REFERENCES Méndez-Álvarez E., Sot
Page 245 and 246: REFERENCES Muller T., Blum-Degen D.
Page 247 and 248: REFERENCES Nunes I., Tovmasian L. T
Page 249 and 250:
REFERENCES Pappolla M. A. (1986) Le
Page 251 and 252:
REFERENCES Papapetropoulos T., John
Page 253 and 254:
REFERENCES Rajput A. H., Rozdilsky
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REFERENCES Roider G. and Drasch G.
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REFERENCES toxicity demonstrates se
Page 259 and 260:
REFERENCES Sedelis M., Hofele K., A
Page 261 and 262:
REFERENCES Sjögren B., Elinder C.
Page 263 and 264:
REFERENCES Strassburger J. and Cobl
Page 265 and 266:
REFERENCES Tsang A. H. and Chung K.
Page 267 and 268:
REFERENCES Verstraeten S. V. (2000)
Page 269 and 270:
REFERENCES Walker V. R., Sutton R.
Page 271 and 272:
REFERENCES Yamamuro A., Yoshioka Y.
Page 273 and 274:
REFERENCES Zapatero M. D., Garcia d
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