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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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- Page 89 and 90: INTRODUCTION Oteiza 1999), non-iron
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- Page 93 and 94: INTRODUCTION mobilization of Ca 2+
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- Page 99 and 100: AIMS OF THE PRESENT THESIS The main
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- Page 110 and 111: CHAPTER 1 INTRODUCTION 86 6-OHDA (2
- Page 112 and 113: CHAPTER 1 MATERIALS AND METHODS Che
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- Page 116 and 117: CHAPTER 1 RESULTS Effects of 6-OHDA
- Page 118 and 119: CHAPTER 1 DISCUSSION 94 As shown by
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- Page 129 and 130: ABSTRACT CHAPTER 2 In the present w
- Page 131 and 132: MATERIALS AND METHODS Chemicals CHA
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- Page 135 and 136: DISCUSSION CHAPTER 2 Aluminium ente
- Page 137: Table 1. Graphite furnace programme
- Page 143 and 144: ABSTRACT CHAPTER 3 The ability of a
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- Page 149 and 150: CHAPTER 3 used as chemical dosimete
- Page 151 and 152: Statistical analysis CHAPTER 3 Data
- Page 153 and 154: CHAPTER 3 was noted in hippocampus
- Page 155 and 156: CHAPTER 3 In vitro effects of alumi
- Page 157 and 158: CHAPTER 3 administration routes (De
- Page 159 and 160: CHAPTER 3 difference in the levels
- Page 161 and 162: CHAPTER 3 Table 1. In vitro effects
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- Page 167 and 168: CHAPTER 3 Fig. 4 Density of striata
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- Page 175 and 176: SUMMARY SUMMARY Aluminium has becom
- Page 177 and 178: SUMMARY stress is reached at this t
- Page 179: CONCLUSIONS
- Page 182 and 183: CONCLUSIONS 5) Intraperitoneal alum
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RESUMEN 1996, Shimohama et al. 2003
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RESUMEN 166 Por último y con el fi
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CONCLUSIONES CONCLUSIONES Los resul
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CONCLUSIONES aumento de grupos carb
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APPENDIX
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APPENDIX Publications arising from
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REFERENCES REFERENCES Aarts M., Liu
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REFERENCES Andersen J. K. (2004) Ox
- Page 207 and 208:
REFERENCES Beckman J. S. and Koppen
- Page 209 and 210:
REFERENCES Bonifati V., Rizzu P., v
- Page 211 and 212:
REFERENCES Cedarbaum J. M. and McDo
- Page 213 and 214:
REFERENCES Cooper J. R., Bloom F. E
- Page 215 and 216:
REFERENCES Deloncle R., Huguet E.,
- Page 217 and 218:
REFERENCES Döllken U. (1897) Ueber
- Page 219 and 220:
REFERENCES Exley C. (2004b) Aluminu
- Page 221 and 222:
REFERENCES (2006) PINK1 protein in
- Page 223 and 224:
REFERENCES Glinka Y., Tipton K. F.
- Page 225 and 226:
REFERENCES Grune T., Jung T., Merke
- Page 227 and 228:
REFERENCES Hegde R., Srinivasula S.
- Page 229 and 230:
REFERENCES Hughes A. J., Ben-Shlomo
- Page 231 and 232:
REFERENCES Variable expression of P
- Page 233 and 234:
REFERENCES Kalaitzakis M. E., Graeb
- Page 235 and 236:
REFERENCES Klintworth H., Garden G.
- Page 237 and 238:
REFERENCES Langston J. W. and Balla
- Page 239 and 240:
REFERENCES Lione A. (1983) The prop
- Page 241 and 242:
REFERENCES Marti M. J., James C.J.,
- Page 243 and 244:
REFERENCES Méndez-Álvarez E., Sot
- Page 245 and 246:
REFERENCES Muller T., Blum-Degen D.
- Page 247 and 248:
REFERENCES Nunes I., Tovmasian L. T
- Page 249 and 250:
REFERENCES Pappolla M. A. (1986) Le
- Page 251 and 252:
REFERENCES Papapetropoulos T., John
- Page 253 and 254:
REFERENCES Rajput A. H., Rozdilsky
- Page 255 and 256:
REFERENCES Roider G. and Drasch G.
- Page 257 and 258:
REFERENCES toxicity demonstrates se
- Page 259 and 260:
REFERENCES Sedelis M., Hofele K., A
- Page 261 and 262:
REFERENCES Sjögren B., Elinder C.
- Page 263 and 264:
REFERENCES Strassburger J. and Cobl
- Page 265 and 266:
REFERENCES Tsang A. H. and Chung K.
- Page 267 and 268:
REFERENCES Verstraeten S. V. (2000)
- Page 269 and 270:
REFERENCES Walker V. R., Sutton R.
- Page 271 and 272:
REFERENCES Yamamuro A., Yoshioka Y.
- Page 273 and 274:
REFERENCES Zapatero M. D., Garcia d