Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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Esta Tesis Doctoral forma parte de los Proyectos de Investigación: “Estudio de los mecanismos de neurotoxicidad del aluminio en procesos degenerativos por estrés oxidativo relacionados con la enfermedad de Parkinson” de la Xunta de Galicia (PGIDIT03PXIB20804PR; 2003-2006). “Búsqueda de un nuevo fármaco para el tratamiento de la enfermedad de Parkinson con una doble acción farmacológica: inhibidora MAO-B y neuroprotectora frente al estrés oxidativo inducido por dopamina” del Ministerio de Ciencia y Tecnología con la contribución del Fondo Europeo de Desarrollo Regional (BFI2003-00493; 2004-2007). “Búsqueda de un nuevo fármaco para el Parkinson: Inhibidor MAO-B y protector de los efectos inducidos por la dopamina sobre la cadena de transporte electrónico mitocondrial” del Ministerio de Ciencia e Innovación (SAF2007-66114; 2007-2010). La realización de esta Tesis ha sido posible gracias a la concesión de las becas y ayudas de la Xunta de Galicia y de Roche Research Foundation (Suiza).
Page 1: Universidade de Santiago de Compost
Page 5: Don Ramón Soto Otero y Doña Estef
Page 10 and 11: Now life is not only science, I wou
Page 12 and 13: Abbreviations (continuation) GSSH o
Page 15 and 16: List of figures Introduction Figure
Page 17: List of tables Introduction Table 1
Page 20 and 21: Intranasal absorption .............
Page 23: INTRODUCTION
Page 26 and 27: INTRODUCTION 2 PD, also called idio
Page 28 and 29: INTRODUCTION Resting tremor 4 Resti
Page 30 and 31: INTRODUCTION disease, especially in
Page 32 and 33: INTRODUCTION diagnosis was substant
Page 34 and 35: INTRODUCTION Table 2: UK Parkinson
Page 36 and 37: INTRODUCTION Neurochemical and neur
Page 38 and 39: INTRODUCTION Figure 5: Dopamine pat
Page 40 and 41: INTRODUCTION accounting each for ap
Page 42 and 43: INTRODUCTION reduced activity in th
Page 44 and 45: INTRODUCTION Degeneration of all DA
Page 46 and 47: INTRODUCTION other brain areas and
Page 48 and 49: INTRODUCTION Figure 13: Six stages
Page 50 and 51: INTRODUCTION kinase 1 (PINK1) (Vale
Page 52 and 53: INTRODUCTION the drug users was fur
Page 54 and 55: INTRODUCTION be largely discussed l
Page 56 and 57:
INTRODUCTION Parkinson diseases: a
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INTRODUCTION Figure 18: The ubiquit
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INTRODUCTION Mitochondrial dysfunct
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INTRODUCTION Oxidative stress 38 Ox
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INTRODUCTION Transition metals: the
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INTRODUCTION Nitric oxide 42 There
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INTRODUCTION have also been demonst
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INTRODUCTION 46 Another pathway has
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INTRODUCTION Cell death pathways 48
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INTRODUCTION Although the 6-OHDA mo
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INTRODUCTION mouse models, such as
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INTRODUCTION and [Al13(OH)30] 9+ .
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INTRODUCTION Iatrogenic exposure 56
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INTRODUCTION et al. 1993), probably
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INTRODUCTION Coble 1987). Transderm
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INTRODUCTION Aluminium influx and e
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INTRODUCTION Aluminium and oxidativ
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INTRODUCTION (Kong et al. 2002). In
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INTRODUCTION 68 As mentioned before
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INTRODUCTION 70 The signal transduc
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AIMS
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AIMS Chapter 3 The third major aim
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OBJETIVOS DE LA PRESENTE TESIS OBJE
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CHAPTER 1
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ABSTRACT CHAPTER 1 The unilateral a
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CHAPTER 1 2001), particularly due t
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Brain samples CHAPTER 1 After decap
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Statistical analysis CHAPTER 1 Resu
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CHAPTER 1 the left striatum and +11
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CHAPTER 1 against degeneration (Tro
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CHAPTER 1 Fig. 1 Changes in TBARS l
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CHAPTER 1 Fig. 3 Changes in PTC in
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CHAPTER 2 Analysis of brain regiona
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CHAPTER 2 INTRODUCTION 106 Aluminiu
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CHAPTER 2 experimental period of fo
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CHAPTER 2 RESULTS Aluminium distrib
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CHAPTER 2 significant increase of t
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CHAPTER 3
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ABSTRACT CHAPTER 3 The ability of a
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CHAPTER 3 not undergo redox reactio
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CHAPTER 3 saline over the same peri
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CHAPTER 3 used as chemical dosimete
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Statistical analysis CHAPTER 3 Data
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CHAPTER 3 was noted in hippocampus
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CHAPTER 3 In vitro effects of alumi
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CHAPTER 3 administration routes (De
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CHAPTER 3 difference in the levels
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CHAPTER 3 Table 1. In vitro effects
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CHAPTER 3 139
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CHAPTER 3 141
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CHAPTER 3 Fig. 4 Density of striata
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CHAPTER 3 145
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CHAPTER 3 147
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SUMMARY SUMMARY Aluminium has becom
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SUMMARY stress is reached at this t
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CONCLUSIONS
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CONCLUSIONS 5) Intraperitoneal alum
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RESUMEN
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RESUMEN 1996, Shimohama et al. 2003
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RESUMEN 166 Por último y con el fi
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CONCLUSIONES CONCLUSIONES Los resul
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CONCLUSIONES aumento de grupos carb
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APPENDIX
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APPENDIX Publications arising from
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REFERENCES REFERENCES Aarts M., Liu
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REFERENCES Andersen J. K. (2004) Ox
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REFERENCES Beckman J. S. and Koppen
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REFERENCES Bonifati V., Rizzu P., v
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REFERENCES Cedarbaum J. M. and McDo
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REFERENCES Cooper J. R., Bloom F. E
Page 215 and 216:
REFERENCES Deloncle R., Huguet E.,
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REFERENCES Döllken U. (1897) Ueber
Page 219 and 220:
REFERENCES Exley C. (2004b) Aluminu
Page 221 and 222:
REFERENCES (2006) PINK1 protein in
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REFERENCES Glinka Y., Tipton K. F.
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REFERENCES Grune T., Jung T., Merke
Page 227 and 228:
REFERENCES Hegde R., Srinivasula S.
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REFERENCES Hughes A. J., Ben-Shlomo
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REFERENCES Variable expression of P
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REFERENCES Kalaitzakis M. E., Graeb
Page 235 and 236:
REFERENCES Klintworth H., Garden G.
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REFERENCES Langston J. W. and Balla
Page 239 and 240:
REFERENCES Lione A. (1983) The prop
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REFERENCES Marti M. J., James C.J.,
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REFERENCES Méndez-Álvarez E., Sot
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REFERENCES Muller T., Blum-Degen D.
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REFERENCES Nunes I., Tovmasian L. T
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REFERENCES Pappolla M. A. (1986) Le
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REFERENCES Papapetropoulos T., John
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REFERENCES Rajput A. H., Rozdilsky
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REFERENCES Roider G. and Drasch G.
Page 257 and 258:
REFERENCES toxicity demonstrates se
Page 259 and 260:
REFERENCES Sedelis M., Hofele K., A
Page 261 and 262:
REFERENCES Sjögren B., Elinder C.
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REFERENCES Strassburger J. and Cobl
Page 265 and 266:
REFERENCES Tsang A. H. and Chung K.
Page 267 and 268:
REFERENCES Verstraeten S. V. (2000)
Page 269 and 270:
REFERENCES Walker V. R., Sutton R.
Page 271 and 272:
REFERENCES Yamamuro A., Yoshioka Y.
Page 273 and 274:
REFERENCES Zapatero M. D., Garcia d
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