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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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- Page 135 and 136: DISCUSSION CHAPTER 2 Aluminium ente
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- Page 144 and 145: CHAPTER 3 INTRODUCTION 120 The huma
- Page 146 and 147: CHAPTER 3 MATERIALS AND METHODS Che
- Page 148 and 149: CHAPTER 3 1:15 for hippocampus and
- Page 150 and 151: CHAPTER 3 initially incorporated to
- Page 152 and 153: CHAPTER 3 RESULTS In vivo effects o
- Page 154 and 155: CHAPTER 3 Effects of aluminium admi
- Page 156 and 157: CHAPTER 3 DISCUSSION 132 Aluminium
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- Page 162 and 163: CHAPTER 3 Fig. 1 Levels of TBARS (A
- Page 164 and 165: CHAPTER 3 Fig. 2 Enzyme activity of
- Page 166 and 167: CHAPTER 3 Fig. 3 Microphotographs s
- Page 168 and 169: CHAPTER 3 Fig. 5 Levels of TBARS (A
- Page 170 and 171: CHAPTER 3 Fig. 6 In vitro effects o
- Page 173: SUMMARY
- Page 176 and 177: SUMMARY values were attained at 48
- Page 178 and 179: SUMMARY neurodegeneration in the DA
- Page 181 and 182: CONCLUSIONS The results obtained in
- Page 183: 13) Aluminium does affect neither M
- Page 188 and 189: RESUMEN 1996, Shimohama et al. 2003
- Page 190 and 191: RESUMEN 166 Por último y con el fi
- Page 193 and 194: CONCLUSIONES CONCLUSIONES Los resul
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- Page 197: APPENDIX
- Page 200 and 201: APPENDIX Publications arising from
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