Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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REFERENCES Hirsch E. C., Brandel J. P., Galle P., Javoy-Agid F. and Agid Y. (1991) Iron and aluminum increase 204 in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56, 446–451. Hirsh E. C., Hunot S., Damier P. and Faucheux B. (1998) Glial cells and inflammation in Parkinson’s disease: a role in neurodegeneration? Ann. Neurol. 44, S115–S120. Hirsch E. C., Hunot S., Faucheux B., Agid Y., Mizuno Y., Mochizuki H., Tatton W. G., Tatton N. and Olanow W. C. (1999) Dopaminergic neurons degenerate by apoptosis in Parkinson’s disease. Mov. Disord. 14, 383–385. Hochstrasser H., Bauer P., Walter U., Behnke S., Spiegel J., Csoti I., Zeiler B., Bornemann A., Pahnke J., Becker G., Riess O., Berg D. (2004) Ceruloplasmin gene variations are associated with substantia nigra hyperechogenicity in Parkinson’s disease. Neurology 63, 1912–1917. Hong S. J., Dawson T. M. and Dawson V. L. (2004) Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol. Sci. 25, 259–264. Hornykiewicz O. and Kish S. J. (1987) Biochemical pathophysiology of Parkinson’s disease. Adv. Neurol. 45, 19–34. Hosovski E., Mastelica Z., Sunderic D. and Radulovic D. (1990) Mental abilities of workers exposed to aluminum. Med. Lav. 81, 119–123. Hsuan S. L., Klintworth H. M. and Xia Z. (2006) Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal- regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. J. Neurosci. 26, 4481– 4491. Hughes A. J., Daniel S. E., Kilford L. and Lees A. J. (1992a) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry. 55, 181–184.
REFERENCES Hughes A. J., Ben-Shlomo Y., Daniel S. E. and Lees A. J. (1992b) What features improve the accuracy of clinical diagnosis in Parkinson’s disease: A clinicopathologic study. Neurology 42, 1142–1146. Hughes A. J., Daniel S. E. and Lees A. J. (1993) The clinical features of Parkinson’s disease in 100 histologically proven cases. Adv. Neurol. 60, 595–599. Hughes A. J., Daniel S. E. and Lees A.J. (2001) Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease. Neurology 57, 1497–1499. Hughes A. J., Daniel S. E., Ben-Shlomo Y. and Lees A. J. (2002) The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125, 861–870. Hunot S., Boissiere F., Faucheux B., Brugg B., Mouatt-Prigent A. and Agid Y. (1996) Nitric oxide synthase and neuronal vulnerability in Parkinson’s disease. Neuroscience 72, 355–363. Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debre P., Agid Y., Dugas B. and Hirsch E. C. (1999) FcepsilonRII/CD23 is expressed in Parkinson’s disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J. Neurosci. 19, 3440–3447. Iaccarino C., Crosio C., Vitale C., Sanna G., Carri M. T. and Barone P. (2007) Apoptotic mechanisms in mutant LRRK2-mediated cell death. Hum. Mol. Genet. 16, 1319–1326. Ibañez P., Bonnet A. M., Debarges B. Lohmann E., Tison F., Pollak P., Agid Y., Dürr A. and Brice A. (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson’s disease. Lancet 364, 1169–1171. Ichitani I., Okamura H., Matsumoto Y., Nagatsu I. and Ibata Y. (1991) Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum. Brain Res. 549, 330–353. Ilic T. V., Jovanovic M., Jovicic A. and Tomovic M. (1999) Oxidative stress indicators are elevated in de novo Parkinson's disease patients. Funct. Neurol. 14, 141–147. 205
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
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CHAPTER 3 1:15 for hippocampus and
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CHAPTER 3 initially incorporated to
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CHAPTER 3 RESULTS In vivo effects o
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CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
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CHAPTER 3 Fig. 1 Levels of TBARS (A
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CHAPTER 3 Fig. 2 Enzyme activity of
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CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
Page 178 and 179: SUMMARY neurodegeneration in the DA
Page 181 and 182: CONCLUSIONS The results obtained in
Page 183: 13) Aluminium does affect neither M
Page 187 and 188: RESUMEN RESUMEN Desde el punto de v
Page 189 and 190: RESUMEN zonas cerebrales excepto en
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Page 194 and 195: CONCLUSIONES Capítulo 2 4) La admi
Page 196 and 197: CONCLUSIONES 172 En base a las conc
Page 199 and 200: Publications as a direct result fro
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Page 204 and 205: REFERENCES Agil A., Duran R., Barre
Page 206 and 207: REFERENCES Baquet Z. C., Bickford P
Page 208 and 209: REFERENCES 184 1,2,3,6-tetrahydropy
Page 210 and 211: REFERENCES 186 compacta of the subs
Page 212 and 213: REFERENCES Chung K. K., Dawson V. L
Page 214 and 215: REFERENCES Davies K. J. (2001) Degr
Page 216 and 217: REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219: REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221: REFERENCES Fleming S. M., Delville
Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
Page 226 and 227: REFERENCES Hamilton E. I., Miniski
Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
Page 232 and 233: REFERENCES Johnson V. J. and Sharma
Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237: REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
Page 242 and 243: REFERENCES McCord J. M. and Fridovi
Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
Page 246 and 247: REFERENCES Nair V. D., McNaught K.,
Page 248 and 249: REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251: REFERENCES Perez F. A. and Palmiter
Page 252 and 253: REFERENCES Przedborski S. and Goldm
Page 254 and 255: REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257: REFERENCES Rymar V. V., Sasseville
Page 258 and 259: REFERENCES Savory J., Herman M. M.
Page 260 and 261: REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263: REFERENCES 238 the generation of hy
Page 264 and 265: REFERENCES Taylor G. A., Moore P. B
Page 266 and 267: REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269: REFERENCES Vila M. and Przedborski
Page 270 and 271: REFERENCES Whitehead M. W., Farrar
Page 272 and 273: REFERENCES Yokel R. A. (2002a) Alum
Page 274: REFERENCES Zhou W., Zhu M., Wilson
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