Occupational Exposure to Carbon Nanotubes and Nanofibers

Table 3–5. Findings from published MWCNT short-term intratracheal (IT)instillation and intrapulmonary spraying toxicology studiesStudy design and exposure/doseAuthor/year Species Exposure routeObserved pulmonary effectsExposureor dose Granuloma Inflammation FibrosisMuller et al. [2005] Rats IT 0.5, 2, 5 mg(eval: 1 hr, 3, 15, 28,and 60 days post exp)+ + +Huczko et al.[2005]G.pigsIT15 mg(eval: 90 dayspost exp)NT(pneumonialikereaction)+ (Increasedlungresistance)+/–Grubek-Jaworskaet al. [2005]G.PigsIT12.5 mg(eval: 90 dayspost exp)+ + +Carrero-Sanchezet al. [2006]Mice IT 1, 2.5,5 mg/kg(eval: 1, 2, 3, 7 and 30days post exp)+ + +Deng et al. [2007] Mice IT 600 µg(eval: 1 daypost exp)Li et al. [2007] Mice IT 0.05 mg(eval: 8, 16, and 24days post exp)Liu et al. [2008] Rats IT 1, 3, 5, and 7 mg/kg(eval: 1 and 7 days, 1and 3 mo. post exp)NR – NRNR + NR+ + NRMuller et al.[2008a]Muller et al.[2008b]Rats IT 2 mg(eval: 3 and 60 dayspost exp)Rats IT 0.5 or 2 mg(eval: 3 days post exp)+ + NRNR + NRInoue et al. [2008] Mice IT 4 mg/kg(eval: 1 day post exp)NR + NRElgrabli et al.[2008a]Rats IT 1, 10, 100 µg(eval: 1, 7, 30, 90 and180 d post exp)– – –See footnotes at end of table.(Continued)NIOSH CIB 65 • Carbon Nanotubes and Nanofibers25