Gene regulation in Streptococcus pneumoniae - RePub - Erasmus ...

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33. Li, S., S. J. Kelly, E. Lamani, M. Ferraroni, and M. J. Jedrzejas. 2000. Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Embo J. 19:1228-40. 34. Loomis, W. F., G. Shaulsky, and N. Wang. 1997. Histidine kinases in signal transduction pathways of eukaryotes. J. Cell. Sci. 110 ( Pt 10):1141-5. 35. Luo, R., B. Mann, W. S. Lewis, A. Rowe, R. Heath, M. L. Stewart, A. E. Hamburger, S. Sivakolundu, E. R. Lacy, P. J. Bjorkman, E. Tuomanen, and R. W. Kriwacki. 2005. Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. Embo J. 24:34-43. Introduction 36. Martner, A., C. Dahlgren, J. C. Paton, and A. E. Wold. 2008. Pneumolysin released during Streptococcus pneumoniae autolysis is a potent activator of intracellular oxygen radical production in neutrophils. Infect. Immun. 76:4079-87. 37. McCluskey, J., J. Hinds, S. Husain, A. Witney, and T. J. Mitchell. 2004. A twocomponent system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. Mol. Microbiol. 51:1661-75. 38. McCullers, J. A., and E. I. Tuomanen. 2001. Molecular pathogenesis of pneumococcal pneumonia. Front. Biosci. 6:D877-89. 39. Mohedano, M. L., K. Overweg, A. de la Fuente, M. Reuter, S. Altabe, F. Mulholland, D. de Mendoza, P. Lopez, and J. M. Wells. 2005. Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition. J. Bacteriol. 187:2357-67. 40. Molle, V., Y. Nakaura, R. P. Shivers, H. Yamaguchi, R. Losick, Y. Fujita, and A. L. Sonenshein. 2003. Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. J. Bacteriol. 185:1911-22. 41. Ng, W. L., K. M. Kazmierczak, and M. E. Winkler. 2004. Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator. Mol. Microbiol. 53:1161-75. 42. Ng, W. L., G. T. Robertson, K. M. Kazmierczak, J. Zhao, R. Gilmour, and M. E. Winkler. 2003. Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6. Mol. Microbiol. 50:1647-63. 21 21
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Page 1 and 2: Gene regulation in Streptococcus pn
Page 3 and 4: Cover image by Duve van Boggelen (w
Page 5 and 6: Promotiecommissie Promotoren: Prof.
Page 8 and 9: CHAPTER 1 Introduction 7
Page 10 and 11: Introduction Figure 1. Infections c
Page 12 and 13: Interestingly, autolysis induced by
Page 14 and 15: histidine kinase is the sensor prot
Page 16 and 17: metabolism are often required for v
Page 18 and 19: egulatory systems, aiming to elucid
Page 20 and 21: 11. Cockeran, R., A. J. Theron, H.
Page 24 and 25: 53. Romero, P., R. Lopez, and E. Ga
Page 26 and 27: CHAPTER 2 Regulation of gene expres
Page 28 and 29: Introduction Streptococcus pneumoni
Page 30 and 31: Materiaals and Meethods Gene regula
Page 32 and 33: (Invitrogen), 0.2 mM aminoallyl dUT
Page 34 and 35: Isolation of pneumococcal RNA durin
Page 36 and 37: Resultss and Discuussion Gene regul
Page 38 and 39: Table 1. Genes regulated by RR09 in
Page 40 and 41: phosphofructokinase, and a fructose
Page 42 and 43: Figure 4. Expression of rlrA and rr
Page 44 and 45: correlated well with our in vitro m
Page 46 and 47: Figure 7. Bacterial loads in blood
Page 48 and 49: Acknowledgments This work was suppo
Page 50 and 51: 10. Ibrahim, Y. M., A. R. Kerr, J.
Page 52 and 53: genome sequence of a virulent isola
Page 54 and 55: Gene regulation by RR09 in S. pneum
Page 56 and 57: Gene regulation by RR09 in S. pneum
Page 58 and 59: Table S4. Genes up- and downregulat
Page 60: Table S6. Genes up- and downregulat
Page 63 and 64: Chapter 3 Abstract 62 62 Previous s
Page 65 and 66: Chapter 3 between the wild-type and
Page 67 and 68: Chapter 3 S. pneumoniae TIGR4 by CS
Page 69 and 70: Chapter 3 performance liquid chroma
Page 71 and 72: Chapter 3 Results Transcriptional a
Page 73 and 74:
Chapter 3 Table 3. Differentially e
Page 75 and 76:
Chapter 3 Figure 2. Colonization mo
Page 77 and 78:
Chapter 3 than the D39ΔpsaR-infect
Page 79 and 80:
Chapter 3 effect was more severe fo
Page 81 and 82:
Chapter 3 in TIGR4ΔpsaR. However,
Page 83 and 84:
Chapter 3 References 1. Adrian, P.
Page 85 and 86:
Chapter 3 21. Hemsley, C., E. Joyce
Page 87 and 88:
Chapter 3 40. McCluskey, J., J. Hin
Page 90 and 91:
CHAPTER 4 CodY of Streptococcus pne
Page 92 and 93:
Introduction Bacteria encounter var
Page 94 and 95:
Materials and Methods Bacterial str
Page 96 and 97:
Table 2. Oligonucleotide primers us
Page 98 and 99:
The CodY regulon of S. pneumoniae I
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The CodY regulon of S. pneumoniae w
Page 102 and 103:
Accession numbers The microarray da
Page 104 and 105:
Table 3. Differentially expressed g
Page 106 and 107:
Binding of CodY to target promoters
Page 108 and 109:
The CodY regulon of S. pneumoniae E
Page 110 and 111:
The CodY regulon of S. pneumoniae F
Page 112 and 113:
Discussion CodY has been described
Page 114 and 115:
levels of adherence in D39. Using a
Page 116 and 117:
References The CodY regulon of S. p
Page 118 and 119:
Glass. 2001. Genome of the bacteriu
Page 120 and 121:
40. Shivers, R. P., S. S. Dineen, a
Page 122 and 123:
CHAPTER 5 Regulation of glutamine a
Page 124 and 125:
Introduction Regulation of nitrogen
Page 126 and 127:
Materials and Methods Nitrogen Meta
Page 128 and 129:
TK136 D39 Δcps; Km R capsule-less
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gene from pORI28, was fused to the
Page 132 and 133:
Construction of lacZ fusions Chromo
Page 134 and 135:
Enzyme assays Cell-free extracts, u
Page 136 and 137:
Reverse-transcriptase PCR RNA isola
Page 138 and 139:
Table 3. Summary of transcriptome c
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effect caused by altered intracellu
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examine whether zwf is only transcr
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(http://www.bd.com/ds/technicalCent
Page 146 and 147:
H6-GlnR alone at the concentration
Page 148 and 149:
Discussion In this study, we charac
Page 150 and 151:
Acknowledgements TK, JB and HB are
Page 152 and 153:
11. den Hengst, C. D., S. A. van Hi
Page 154 and 155:
Nitrogen Metabolism in S. pneumonia
Page 156 and 157:
52. Wray, L. V., Jr., J. M. Zalieck
Page 158 and 159:
CHAPTER 6 Site-specific contributio
Page 160 and 161:
Introduction GlnR-regulon and pneum
Page 162 and 163:
Materials and Methods Bacterial str
Page 164 and 165:
eferred to as t=0. Bacteriology res
Page 166 and 167:
Results GlnR-regulon and pneumococc
Page 168 and 169:
Figure 3. Colonization model. Bacte
Page 170 and 171:
GlnR-regulon and pneumococcal virul
Page 172 and 173:
Table 2. Differentially expressed g
Page 174 and 175:
Discussion The ability to adequatel
Page 176 and 177:
The microarray data showed that pre
Page 178 and 179:
Acknowledgments WTH is supported by
Page 180 and 181:
12. Ibrahim, Y. M., A. R. Kerr, J.
Page 182 and 183:
33. Zalieckas, J. M., L. V. Wray, J
Page 184 and 185:
CHAPTER 7 Pneumococcal gene regulat
Page 186 and 187:
Introduction Regulation of gene exp
Page 188 and 189:
Gene regulation and metabolism in S
Page 190 and 191:
makes it possible for the pneumococ
Page 192 and 193:
A CcpA homologue exists in the pneu
Page 194 and 195:
double mutant, suggesting direct re
Page 196 and 197:
References Gene regulation and meta
Page 198 and 199:
23. Kerr, A. R., P. V. Adrian, S. E
Page 200 and 201:
45. Sonenshein, A. L. 2005. CodY, a
Page 202 and 203:
CHAPTER 8 Summarizing discussion 20
Page 204 and 205:
that the observed virulence phenoty
Page 206 and 207:
CodY was found to be required for a
Page 208 and 209:
References Summarizing discussion 1
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Summarizing discussion 21. Orihuela
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Samenvatting en discussie Curriculu
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Samenvatting en discussie kunnen ge
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Bevindingen die dit onderbouwen, we
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Curriculum Vitae Curriculum Vitae W
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Dankwoord Jeetje, dat het dan toch
Page 222:
oekje en ik kijk uit naar de bijbeh
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