International Summer School PROGRAM - Laboratoire d'Infochimie ...

Synthetic vesicle membranes: Molecular recognition and reactivity at
the interface
Benjamin Gruber, Burkhard König*
University of Regensburg, Universitätsstraße 31, 93053 Regensburg
*e-mail: burkhard.koenig@chemie.uni-regensburg.de
Many fundamental biological processes take place at the membrane-water interface of
cells and involve membrane-proteins that act as receptors for external signaling
molecules or catalyze enzymatic reactions. Here we present some of our recent studies
about artificial receptors embedded in synthetic vesicle membranes [1-2] and vesicular
metal complexes promoting the hydrolysis of phosphodiester substrates. [3]
Figure 1. Vesicle membrane embedding of receptors and dyes for self-assembled
chemosensors (left) and metal catalysts for the cleavage of phosphodiesters (right).
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[1] B. Gruber, S. Stadlbauer, K. Woinaroschy, B. König, Org. Biomol. Chem. 2010, 8,
3704.
[2] B. Gruber, S. Stadlbauer, A. Späth, S. Weiss, M. Kalinina, B. König, Angew. Chem.
Int. Ed. 2010, 49, 7125.
[3] M. Subat, K. Woinaroschy, C. Gerstl, B. Sarkar, W. Kaim, B. König, Inorg. Chem.
2008, 47, 4661.