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Synthesis and Investigations of Multiple Hydrogen Bonded Supramolecular Host - Guest Complexes Philipp Otte, Ulrich Lüning* Otto-Diels-Institut für Organische Chemie, Olshausenstraße 40, 24098 Kiel, GER. potte@oc.uni-kiel.de, luening@oc.uni-kiel.de In supramolecular chemistry, molecular recognition via non-covalent binding sites such as hydrogen bonds is common. It is necessary to have complementary hydrogen bond acceptor (A) and hydrogen donor (D) patterns. A single hydrogen bond is relatively weak, but the combination of multiple hydrogen bonds can lead to stable host - guest complexes. [1] nBu O N H O nBu N N H H N N N H N CN O N H O R nBu R = (CH 2CH 2O) 3OEt nBu N H X N N N R H H H N N N O O H3C CH 3 X = O, S R = CO(CH2CH2O) 3Et (CO)CH3 H It is reasonable to synthesize molecules whose preferred conformation is the one which can form the highest number of hydrogen bonds. If an intramolecular bond has to be broken to get the needed binding pattern, a loss of energy at the expense of the complex stability would be the consequence. [2] Therefore, the aim should be to stabilize [3] the preferred conformation by using, for example, intramolecular hydrogen bonds. nBu N H X N N N R H H H X N N X = O, S nBu R = CO(CH2CH2O) 3Et N N R H Due to the orthogonality of the binding sites, highly specific dendrimeric systems could be generated. [1] J. Taubitz, U. Lüning, Eur. J. Org. Chem. 2008, 5922-5927. [2] S. Brammer, U. Lüning, C. Kühl, Eur. J. Org. Chem. 2002, 4054-4062. [3] E.W. Meijer et al. Science 1997, 278, 1601-1604. H nBu N H O H N H N CH 3 N O
Victor Pavlovsky Ukraine, Odessa "Structure of Derivates of 1,4-Benzodiazepine and their Affinity for Central and Peripheral Benzodiazepine Receptors"
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4 th International Summer School Se
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4 th International Summer School
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Tuesday, September 13 th 9 - 10.30
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4.30 - 5.30 pm Poster Short Talks (
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2.30 - 4 pm Session VIII (Inorganic
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11.30 - 12.00 am Olga Federova, Mos
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INNOVATIVE DEVELOPMENTS ON THE BASI
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Calixarenes: from molecular recepto
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Controlled and Targeted Drug Delive
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What does the recognition of biomol
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Binding properties of calix[4]arene
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“Light and Molecular Design in Bi
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Supramolecular protein immobilizati
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Cucurbiturils at the interface betw
Page 29 and 30: Chiral Concave N-Heterocyclic Carbe
Page 31 and 32: Aromaticity Switching In Porphyrino
Page 33 and 34: Zwitterion-chromophore modules for
Page 35 and 36: Chemoinformatics approaches to virt
Page 37 and 38: Polyphosphorus Ligands in Supramole
Page 39 and 40: Lithium-controlled hierarchical ass
Page 41 and 42: Luisa De Cola Germany, Münster "Se
Page 43 and 44: Cationic amphiphilic calixarenes: s
Page 45 and 46: Supramolecular devices based on pho
Page 47 and 48: The sensing of interfacial interact
Page 49 and 50: Molecular recognition of organic qu
Page 51 and 52: Towards a molecular assembly based
Page 53 and 54: Analysis of benzodiaza-15-crown-5 e
Page 55 and 56: Crown-containing derivatives of nap
Page 57 and 58: Tuning of Knoevenagel-type substrat
Page 59 and 60: FRET based distance measurements on
Page 61 and 62: Synthesis and supramolecular associ
Page 63 and 64: The features of the coordination ne
Page 65 and 66: Catalysts within Dynamic Combinator
Page 67 and 68: SYNTHESIS AND COMPLEXATION ABILITIE
Page 69 and 70: Towards a Light Driven Proton Pump
Page 71 and 72: HPLC study of the complexation of c
Page 73 and 74: Novel fluorescent sensors based on
Page 75 and 76: SYNTHETIC TETRAAMIDES ANION RECEPTO
Page 77 and 78: Development of Vesicle-based Chemos
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Page 83 and 84: Synthesis of disubstituted by merca
Page 85 and 86: SUPRAMOLECULAR POLYMERS OF OLIGO-DY
Page 87 and 88: Investigation of self-assembling ab
Page 89 and 90: Conjugates of thiacalixarenes and c
Page 91 and 92: Chromogenic Anion Receptors Based o
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Page 95: Universität Regensburg - direction
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