International Summer School PROGRAM - Laboratoire d'Infochimie ...

SUPRAMOLECULAR CHEMISTRY OF CALIXARENES.
FUNDAMENTAL AND PRACTICAL ASPECTS
Vitaly Kalchenko
Institute of Organic Chemistry, National Academy of Sciences of Ukraine
02660, Kiev-94, Ukraine, vik@ioch.kiev.ua, www.ioch.kiev.ua/calix
Calixarenes are versatile molecular scaffolds for design of highly efficient and selective
receptors, self-assembling systems and well defined functional nanostructures. The
paper will report the molecular modeling, synthesis, structural investigations of
phosphorus, nitrogen and sulfur containing (thia)calixarenes and their supramolecular
complexes with a series of bio-relevant or ecologically hazardous molecules, cations
and anions.
The special attention will be paid to chiral and water-soluble calixarenes in
context of bio-medical investigations. An application of the P,N,S-containing
calixarenes toward radionuclides extraction, chemosensors constructions, functional
nanoparticles formations and drug design will be discussed.
References:
[1] For review see: Cherenok S., Dutasta J.-P., Kalchenko V. Current Organic
Chemistry. 2006.10. 2307-2331; Kalchenko V. UPAC. 2008. 80. 1449-1458; Rodik
R.V., Boyko V.I., Kalchenko V. I. Current Medicinal Chemistry. 2009. 16 (13), 1630-
1655. Cherenok S., Kalchenko V. Topics in Heterocyclic Chemistry. 2009. 20. 229-273.
[2] Kasyan O., Kalchenko V., Bolte V., Bohmer V. Chem. Commun. 2006. 1932–1934.
[3] Cherenok S., Vovk A., Muravyova I., Shivanyuk A., Kukhar V., Lipkowski J.,
Kalchenko V. Organic Letters. 2006. 8. 549-551.
[4] Notestein J.M., Andrini L.R., Kalchenko V.I., Requejo F.J., Katz A., Iglesia E.
J. Am. Chem. Soc. 2007. 129. 1123-1131.
[5] Cherenok S., Vovk A., Muravyova I., Shivanyuk A., Kukhar V., Lipkowski J.,
Kalchenko V.Organic Letters. 2006. 8. 549-552.
[6] Torgov V.G., Us T.V., Korda T.M., Kostin G.A., Miroshnichenko S.I., Klimchuk
O.V., Kalchenko V.I. J. Inclusion Phenomena and Macrocyclic Chemistry. 2008. 62.
51-58.
[7] Klyachina M.А., Yesypenkо O.A., Pyrozhenko V.V., Shishkina S.V., Shishkin
O.V., Boyko V.І., Kalchenko V.I. Tetrahedron. 2009. 65. 7085-7091.
[8] Ha J.-M., Katz A., Drapailo A.B., Kalchenko V. I. J. Phys. Chem. C. 2009. 113.
1137-1142.
[9] Vovk A.I., Kononets L.A., Tanchuk V.Yu, Cherenok S.O., Drapailo A.B.,
Kalchenko V.I., Kukhar V.I. Bioorg. Med. Chem. Lett. 2010. 20. 483–487.
[10] Solovyov A.V., Cherenok S.O., Kalchenko O.I., Atamas L.I., Kazantseva Z.I., Koshets I.A.,
Tsymbal I.F., Kalchenko V.I. Journal of Molecular Liquids. 2011. 159. 117–123.