Presentation Outline ICHP Annual Meeting September 13-15

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Prostacyclin Analogues: Intravenous, Subcutaneous, or Inhaled Epoprostenol ( (Flolan Flolan ® or Veletri ® ) Treprostinil (Remodulin ® ) Treprostinil (Remodulin ® ) Iloprost Iloprost (Ventavis ® ) Treprostinil (Tyvaso ® ) Approved uses: Epoprostenol IV: FC III-IV, 2 ng/kg/min titrated to desired clinical response in 1-2 ng/kg/min increments. Treprostinil IV / SC: FC II-IV, 1.25-2.5 ng/kg/min/wk. IV=diluted. Inhaled: FC III, to 54 mcg, 4 inh/d. Iloprost Inhaled: FC III-IV, 2.5-5 mcg, 6-9 inh/d. Prostacyclin Analogues: Pivotal Trials Study Name / Drug AIR Inhaled iloprost vs placebo TRIUMPH 1 Inhaled treprostinil vs placebo § SQ treprostinil vs SQ placebo TRUST IV treprostinil vs placebo IV epoprostenol vs conventional Rx IV epoprostenol vs conventional Rx N / Etiology / Class 203 PH III-IV Design Positive Results Double-blind 12-week • Composite end point •6MWD • Symptoms • Hemodynamics 235 Double-blind •6MWD PAH 12-week on III-IV* background oral Rx 470 Double-blind •6MWD PAH 12-week • Symptoms II-IV • Hemodynamics y 44 Double‐blind, placebo‐ • 6MWD PAH controlled • Symptoms III 2‐week 81 Open-label •6MWD IPAH/FPAH 12-week • Symptoms III,IV • Hemodynamics • Survival 111 Open-label •6MWD APAH SSc 12-week • Hemodynamics III,IV • Symptoms *Approved for class III only. § Included background therapy with ERA or PDE5-I. Olschewski H, et al. N Engl J Med. 2002;347:322-329; Simonneau G, et al. Am J Respir Crit Care Med. 2002;165:800-804; Barst RJ, et al. N Engl J Med. 1996;334:296-301; McLaughlin VV, et al. Am J Respir Crit Care Med. 2008;177:A965. McLaughlin VV, et al. J Am Coll Cardiol. 2010;55:1915-1922. Badesch D, et al. Ann Intern Med 2000;132(6):425-432. Hiremath J, et al. J Heart Lung Transplant. 2010;29:137-149. IV Epoprostenol in IPAH: Change From Baseline in 6MWD Mediann change from baaseline (m) 40 30 20 10 0 ‐10 ‐20 ‐30 31 Epoprostenol (n=41; baseline=315 m) p
IV Epoprostenol in PAH Due to Sclero-derma: Change From Baseline in 6MWD Median changge from baseline (m) 80 60 40 20 0 -20 -40 -60 Badesch D, et al. Ann Intern Med. 2000;132:425-434. (%) 100 80 60 Conventional therapy (n=55) Epoprostenol (n=56) p=0.003 Week 1 p
Page 1 and 2: ACTIVITY DESCRIPTION Target Audienc
Page 3 and 4: Current Challenges • Expansion of
Page 5 and 6: Examples of Medication Consideratio
Page 7 and 8: Etiology (Dana Point, 2008) 1’. P
Page 9 and 10: PAH Therapy Targets Schulze-Neick I
Page 11 and 12: Chronic Adjuvant Therapies in PAH D
Page 13 and 14: Cummulative suurvival Survival in I
Page 15 and 16: ACCF/AHA Consensus PAH Treatment Al
Page 17: Study Name Drug SUPER-1 Oral silden
Page 21 and 22: 70 60 50 40 30 20 10 Inhaled Ilopro
Page 23 and 24: Conclusions • PAH therapy improve
Page 25 and 26: ESC/ERS Guidelines Galie N, et al.
Page 27 and 28: FUTURE DIRECTIONS WHICH MAY IMPACT
Page 29 and 30: Rationale for “Front-Loaded” Ap
Page 31 and 32: Addressing gthe Challenges g in PAH
Page 33 and 34: Considerations • Central vs. peri
Page 35 and 36: Pulmonary Hypertension • Approxim
Page 37 and 38: Example Cassette Calculations • V
Page 39 and 40: Assessment Question 1 Which of the
Page 41 and 42: Illinois Council of Health‐System
Page 43 and 44: Patient Activity ‐ 1 Patients in
Page 45 and 46: Hospitalists National Trends • Ja
Page 47 and 48: Pharmacy Landscape • PGY‐2: So
Page 49 and 50: Primary Care Physicians by Field, F
Page 51 and 52: Health Systems Pharmacy and TATAI
Page 53 and 54: Readings The 21 Irrefutable Laws of
Page 55 and 56: What is a “Practice Model”? •
Page 57 and 58: Completing the Self Assessment •
Page 59 and 60: Residency trained (B23p) Illinois N
Page 61 and 62: Solving the PPMI Puzzle ‐ Here Ar
Page 63 and 64: Overview of Value Based Purchasing
Page 65 and 66: Implementation of Medication‐ rel
Page 67 and 68: Question #1 Within which programs a
Page 69 and 70:
Solving the PPMI Puzzle‐ Here are
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Discharge Education/Med Rec • New
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Media‐Worthy Trials? Making Sense
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Prevention of Recurrent VTE • Unp
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VTE recurrence during study period
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Which patient might be a candidate
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Azithromycin and CV Death • Endpo
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Azithromycin and CV Death Azithromy
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Hormonal Contraception and VTE •
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• Age • Calendar year • Educa
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ARR=2.20, 2.28 for stroke, MI when
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Which of the following combinations
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3 Months of Treatment for Latent TB
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3 Months of Treatment for Latent TB
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T/F: Rifapentine in combination wit
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2. Which of the following statement
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Fitting the Counseling Piece into M
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Current Evidence: Implementing Bund
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Teach Back Process • Step 1 Expla
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Questions for Consideration and Dis
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Why do we care about ADE? • Adver
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True or False • Medication errors
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Check Point Which of the following
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Proactive Screening Process Patient
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MTI Pilot at NAH PharmD Students tr
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ASHP PPMI Case Study Adding Value:
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Interdisciplinary Teamwork: How Phy
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Highly Effective Healthcare • Wha
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Inter‐Professional Teams ‐ Chan
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Meeting the PPMI Goals for Technolo
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Drug‐Bug Mismatch Example Con’t
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Drug‐Bug Mismatch Build Rules •
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Patient Scanning Compliance Sample
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Page 139 and 140:
Global Immunizations 3 • Jan 2012
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Mobile Devices: Beyond Angry Birds
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Google Play • Google Play - Inter
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Other Useful Productivity Apps •
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Mobile Devices: Beyond Angry Birds
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Net Activations by Industry Source:
Page 151 and 152:
News Readers/Aggregators Features S
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Contact Information • E‐mail: -
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Early‐Onset Sepsis • Sign and s
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• BR is on day 2 of cefotaxime wi
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Immunizations: The Superheroes to P
Page 161 and 162:
Current ACIP Recommendations Influe
Page 163 and 164:
Herpes Zoster Vaccine Recommendatio
Page 165 and 166:
Assessment Questions 1. What are th
Page 167 and 168:
HIV Linkage and Retention in Care T
Page 169 and 170:
DHHS Guidelines, March 2012: When t
Page 171 and 172:
Protease Inhibitors • Require “
Page 173 and 174:
Mean Change (mg/ /dL) STARTMRK: Lip
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RAL Drug Interactions • Does not
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Instructions for Credit In order to
Page 179 and 180:
Staging Stage Criteria (Durie‐Sal
Page 181 and 182:
Salvage Therapy Partial List Regime
Page 183 and 184:
Bortezomib-Thalidomide-Dexamethason
Page 185 and 186:
Case 2 ST is a 76 y/o African Ameri
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Thalidomide and Lenalidomide • Ad
Page 189 and 190:
Fixed Low-Dose Warfarin Study Thera
Page 191 and 192:
New Drugs 2012 Anna Nowobilski‐Va
Page 193 and 194:
Pulmonology » Cystic Fibrosis •
Page 195 and 196:
Oncology » MTX Toxicity • MTX 1o
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NEW DRUGS AND BIOLOGICALS 2012 RESO
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Disease State Reviews for Pharmacy
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Chronic Obstructive Pulmonary Disea
Page 203 and 204:
Page 205 and 206:
Green Zone • Patient is not havin
Page 207 and 208:
Page 209 and 210:
• A hormone produced by the pancr
Page 211 and 212:
Unraveling Unraveling The The Puzzl
Page 213 and 214:
The Reward Center In time, serious
Page 215 and 216:
So what makes addicted pharmacists
Page 217 and 218:
How to find a treatment center Onli
Page 219 and 220:
Internet Drug Abuse Study conducted
Page 221 and 222:
NIAAA = best resource for alcohol d
Page 223 and 224:
Impact of Postoperative Pain • Pi
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Safety Profile • Amar et al confi
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References 1. Rømsing J, Møiniche
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Society of Regional Anesthesia Meet
Page 231 and 232:
A New Approach IV Acetaminophen •
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References • Schechter, Leslie N.
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Bupivacaine liposome injectable sus
Page 237 and 238:
Error Potential • Inadvertent IV
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Decolonization Methods • Anti-sep
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Evidence: Inpatient ICU MRSA Coloni
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Residency Project Pearls Adherence
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650 subjects id identified tifi d R
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Overtreatment versus Appropriate Tr
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Adherence to and Outcomes Associate
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Background • Lack of comprehensiv
Page 253 and 254:
Results Results‐User User Audits
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Special thanks to: • Carol Heunis
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Antibiotic Prophylaxis American Hea
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Study Limitations • Dependent on
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Study Background • Observation of
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A patient has a CrCl of 25 mL/min.
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• Cysteine hydrochloride: antioxi
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Sample Preparation • Intravenous
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Questions? Residency Project Pearls
Page 271 and 272:
The Interview: Your Preparation •
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PGY1 Residency Options Carol Heunis
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RESIDENCY PROGRAM BASICS • Progra
Page 277 and 278:
CV: The key to a top curriculum vit
Page 279 and 280:
Tips for a Top Notch CV • Focus o
Page 281 and 282:
What is PhORCAS? • PhORCAS is the
Page 283 and 284:
Piecing together the new CHEST guid
Page 285 and 286:
Initiating therapy CHEST 2012 2.1.8
Page 287 and 288:
What is “Consistently Stable?”
Page 289 and 290:
Puzzle # 2A: patient has just compl
Page 291 and 292:
What would you do for JJ? • A. Ho
Page 293 and 294:
Considerations for SB • Bleeding
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Presentation Outline ICHP Annual Meeting September 13-15

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