Presentation Outline ICHP Annual Meeting September 13-15

A New Approach
IV Acetaminophen
• Proposed Benefits
– Decreased utilization of morphine equivalents
• Less opioid‐related adverse effects
– Earlier mobilization
• Increased physical therapy participation
• Decreased risk of DVT
– Decreased length of stay
• Reduction of hospital cost
– Increased patient satisfaction
A New Approach
IV Acetaminophen
• Disadvantages
– Kinetics
• Tmax: more predictable than other routes of acetaminophen
• Analgesic effect of multiple routes similar
• Analgesic effect of rectal formulation prolonged
– Patient selection
• Contraindicated with severe liver impairment or acute liver disease
• Use with caution:
– Alcoholism, malnutrition, hepatic impairment, renal impairment
(CrCl