Presentation Outline ICHP Annual Meeting September 13-15

Stroke, MI, and
Hormonal Contraception
• Study cohort
– Danish population from 1995 to 2009
Inclusion (and Endpoint Inclusion) Exclusion (and Endpoint Exclusion)
Diagnostic code of “transient
Women 15 to 49 years y of age g
iischemic h i attack” k”
Diagnostic codes for “cerebral
infarction” and “cerebral
apoplexy”
Prior diagnosis of venous or
arterial thrombotic event
Acute myocardial infarction Cancer (prior to study period)
Gynecologic surgeries (some
censored)
Censored –pregnancy and
coagulation disorders
N Engl J Med. 2012;366(24):2257-2266.
Stroke, MI, and
Hormonal Contraception
• Prescription/Lifestyle Data
– Obtained from The Register of Medicinal Product
Statistics
– Categorized by: estrogen dose, dose progestin type, type
route of administration
– Duration of use: Rx fill date to last fill date/event
– Rxs for DM, arrhythmia, HTN, hyperlipidemia
– Smoking habits (from National Registry)
N Engl J Med. 2012;366(24):2257-2266.
http://laegemiddelstyrelsen.dk/en/topics/statistics,-prices-and-reimbursement/statistics-andanalyses/about-the-register-of-medicinal-product---tatistics-.
Stroke, MI, and
Hormonal Contraception
• Endpoints
– First‐ever thrombotic stroke and myocardial
infarction
N Engl J Med. 2012;366(24):2257-2266.
8/30/2012
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