Presentation Outline ICHP Annual Meeting September 13-15

Bupivacaine liposome injectable
suspension (Exparel)
Multivesicular Liposomes
http://www.exparel.com/images/exparel_how_to_use.jpg
Efficacy
Primary efficacy endpoint:
Pain intensity score summation over time
Percentage of Patients Pain‐free vs Hours
Golf, et al. Adv Ther. 2011;28:776-88
Liposomal bupivacaine 120 mg
Placebo
FDA Approval
Based on two clinical trials
• Bunionectomy (Golf 2011)
• Hemorrhoidectomy (Gorfine 2011)
Golf, et al. Adv Ther. 2011;28:776-88
Gorfine et al. Dis Colon Rectum. 2011;54:1552-9.
Efficacy
Primary efficacy endpoint:
Pain intensity score summation over time
No benefit beyond 24 hours
No Opioid Rescue Medications vs Hours
Golf, et al. Adv Ther. 2011;28:776-88
Liposomal bupivacaine 120 mg
Placebo
8/29/2012
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