Presentation Outline ICHP Annual Meeting September 13-15

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Cumulative Pain Score through 72 Hours Cumulativ ve Pain Score Gorfine et al. Dis Colon Rectum. 2011;54:1552-9. P < 0.0001 No Opioid Rescue Medications vs Hours Gorfine et al. Dis Colon Rectum. 2011;54:1552-9. Liposomal bupivacaine 300 mg Placebo FDA Review “Between 24 and 72 hours after study drug administration, there was minimal to no difference between EXPAREL and placebo treatments on mean pain intensity; however, there was an attendant decrease in opioid consumption, the clinical benefit of which was not demonstrated.” Mean Total Amount of Opioids Over 72 Hr Milligramss (mg) Gorfine et al. Dis Colon Rectum. 2011;54:1552-9. Marketing P < 0.006 “One dose of Exparel provides up to 72 hours of postsurgical pain control with a decrease in opioid consumption without the need for catheters or pumps.” Safety • No primary safety outcome defined • Identified opioid‐ related adverse effects 8/29/2012 3
Error Potential • Inadvertent IV administration • Institute for Safe Medication Practices (ISMP) issued warning http://www.drugdevelopment-technology.com/projects/6855/images/138835/large/1-bottle.jpg http://wbma.images.worldnow.com/images/19134941_BG2.jpg Bupivacaine liposome injectable suspension (Exparel) Recommend to add to formulary aa. Yes b. NO http://www.drugdevelopment‐technology.com/projects/6855/images/138835/large/1‐bottle.jpg Unpublisheed Trials 8 Unpublished Trials plain bupivacaine as active comparator 3 Liposomal bupivacaine better 5 No benefit over plain bupivacaine Decisions, Decisions…Debates in Therapeutics Bupivacaine liposomal injection Will it stick around? Elizabeth Short, Pharm.D. PGY2 Critical Care Northwestern Memorial Hospital 8/29/2012 4
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ACTIVITY DESCRIPTION Target Audienc
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Current Challenges • Expansion of
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Examples of Medication Consideratio
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Etiology (Dana Point, 2008) 1’. P
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PAH Therapy Targets Schulze-Neick I
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Chronic Adjuvant Therapies in PAH D
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Cummulative suurvival Survival in I
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ACCF/AHA Consensus PAH Treatment Al
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Study Name Drug SUPER-1 Oral silden
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IV Epoprostenol in PAH Due to Scler
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70 60 50 40 30 20 10 Inhaled Ilopro
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Conclusions • PAH therapy improve
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ESC/ERS Guidelines Galie N, et al.
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FUTURE DIRECTIONS WHICH MAY IMPACT
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Rationale for “Front-Loaded” Ap
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Addressing gthe Challenges g in PAH
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Considerations • Central vs. peri
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Pulmonary Hypertension • Approxim
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Example Cassette Calculations • V
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Assessment Question 1 Which of the
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Illinois Council of Health‐System
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Patient Activity ‐ 1 Patients in
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Hospitalists National Trends • Ja
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Pharmacy Landscape • PGY‐2: So
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Primary Care Physicians by Field, F
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Health Systems Pharmacy and TATAI
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Readings The 21 Irrefutable Laws of
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What is a “Practice Model”? •
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Completing the Self Assessment •
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Residency trained (B23p) Illinois N
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Solving the PPMI Puzzle ‐ Here Ar
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Overview of Value Based Purchasing
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Implementation of Medication‐ rel
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Question #1 Within which programs a
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Solving the PPMI Puzzle‐ Here are
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Discharge Education/Med Rec • New
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Media‐Worthy Trials? Making Sense
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Prevention of Recurrent VTE • Unp
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VTE recurrence during study period
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Which patient might be a candidate
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Azithromycin and CV Death • Endpo
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Azithromycin and CV Death Azithromy
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Hormonal Contraception and VTE •
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• Age • Calendar year • Educa
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ARR=2.20, 2.28 for stroke, MI when
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Which of the following combinations
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3 Months of Treatment for Latent TB
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3 Months of Treatment for Latent TB
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T/F: Rifapentine in combination wit
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2. Which of the following statement
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Fitting the Counseling Piece into M
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Current Evidence: Implementing Bund
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Teach Back Process • Step 1 Expla
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Questions for Consideration and Dis
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Why do we care about ADE? • Adver
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True or False • Medication errors
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Check Point Which of the following
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Proactive Screening Process Patient
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MTI Pilot at NAH PharmD Students tr
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ASHP PPMI Case Study Adding Value:
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Interdisciplinary Teamwork: How Phy
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Highly Effective Healthcare • Wha
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Inter‐Professional Teams ‐ Chan
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Meeting the PPMI Goals for Technolo
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Drug‐Bug Mismatch Example Con’t
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Drug‐Bug Mismatch Build Rules •
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Patient Scanning Compliance Sample
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Global Immunizations 3 • Jan 2012
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Mobile Devices: Beyond Angry Birds
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Google Play • Google Play - Inter
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Other Useful Productivity Apps •
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Mobile Devices: Beyond Angry Birds
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Net Activations by Industry Source:
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News Readers/Aggregators Features S
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Contact Information • E‐mail: -
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Early‐Onset Sepsis • Sign and s
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• BR is on day 2 of cefotaxime wi
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Immunizations: The Superheroes to P
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Current ACIP Recommendations Influe
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Herpes Zoster Vaccine Recommendatio
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Assessment Questions 1. What are th
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HIV Linkage and Retention in Care T
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DHHS Guidelines, March 2012: When t
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Protease Inhibitors • Require “
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Mean Change (mg/ /dL) STARTMRK: Lip
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RAL Drug Interactions • Does not
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Instructions for Credit In order to
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Staging Stage Criteria (Durie‐Sal
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Salvage Therapy Partial List Regime
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Bortezomib-Thalidomide-Dexamethason
Page 185 and 186: Case 2 ST is a 76 y/o African Ameri
Page 187 and 188: Thalidomide and Lenalidomide • Ad
Page 189 and 190: Fixed Low-Dose Warfarin Study Thera
Page 191 and 192: New Drugs 2012 Anna Nowobilski‐Va
Page 193 and 194: Pulmonology » Cystic Fibrosis •
Page 195 and 196: Oncology » MTX Toxicity • MTX 1o
Page 197 and 198: NEW DRUGS AND BIOLOGICALS 2012 RESO
Page 199 and 200: Disease State Reviews for Pharmacy
Page 201 and 202: Chronic Obstructive Pulmonary Disea
Page 205 and 206: Green Zone • Patient is not havin
Page 209 and 210: • A hormone produced by the pancr
Page 211 and 212: Unraveling Unraveling The The Puzzl
Page 213 and 214: The Reward Center In time, serious
Page 215 and 216: So what makes addicted pharmacists
Page 217 and 218: How to find a treatment center Onli
Page 219 and 220: Internet Drug Abuse Study conducted
Page 221 and 222: NIAAA = best resource for alcohol d
Page 223 and 224: Impact of Postoperative Pain • Pi
Page 225 and 226: Safety Profile • Amar et al confi
Page 227 and 228: References 1. Rømsing J, Møiniche
Page 229 and 230: Society of Regional Anesthesia Meet
Page 231 and 232: A New Approach IV Acetaminophen •
Page 233 and 234: References • Schechter, Leslie N.
Page 235: Bupivacaine liposome injectable sus
Page 239 and 240: Decolonization Methods • Anti-sep
Page 241 and 242: Evidence: Inpatient ICU MRSA Coloni
Page 243 and 244: Residency Project Pearls Adherence
Page 245 and 246: 650 subjects id identified tifi d R
Page 247 and 248: Overtreatment versus Appropriate Tr
Page 249 and 250: Adherence to and Outcomes Associate
Page 251 and 252: Background • Lack of comprehensiv
Page 253 and 254: Results Results‐User User Audits
Page 255 and 256: Special thanks to: • Carol Heunis
Page 257 and 258: Antibiotic Prophylaxis American Hea
Page 259 and 260: Study Limitations • Dependent on
Page 261 and 262: Study Background • Observation of
Page 263 and 264: A patient has a CrCl of 25 mL/min.
Page 265 and 266: • Cysteine hydrochloride: antioxi
Page 267 and 268: Sample Preparation • Intravenous
Page 269 and 270: Questions? Residency Project Pearls
Page 271 and 272: The Interview: Your Preparation •
Page 273 and 274: PGY1 Residency Options Carol Heunis
Page 275 and 276: RESIDENCY PROGRAM BASICS • Progra
Page 277 and 278: CV: The key to a top curriculum vit
Page 279 and 280: Tips for a Top Notch CV • Focus o
Page 281 and 282: What is PhORCAS? • PhORCAS is the
Page 283 and 284: Piecing together the new CHEST guid
Page 285 and 286: Initiating therapy CHEST 2012 2.1.8
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What is “Consistently Stable?”
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Puzzle # 2A: patient has just compl
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What would you do for JJ? • A. Ho
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Considerations for SB • Bleeding
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Presentation Outline ICHP Annual Meeting September 13-15

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