Presentation Outline ICHP Annual Meeting September 13-15

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Roberto F. Machado, MD Associate Professor of Medicine Section of Pulmonary, Critical Care Medicine, Sleep and Allergy FACULTY Heather R. Bream-Rouwenhorst, PharmD, BCPS Clinical Assistant Professor University of Iowa College of Pharmacy Clinical Pharmacy Specialist–Cardiology U i it f I H it l & Cli i Iowa City, IA Institute for Personalized RRespiratory i t MMedicine di i University of Iowa Hospitals & Clinics University of Illinois at Chicago College of Medicine Chicago, IL James C. Coons, PharmD, BCPS (AQ Cardiology) Associate Professor University of Pittsburgh School of Pharmacy Department of Pharmacy & Therapeutics Pittsburgh, PA DISCLOSURES Planning Committee Members Heather R. Bream-Rouwenhorst, PharmD, BCPS Paul DeLisle James C. Coons PharmD, BCPS (AQ Cardiology) Marco Cicero, PhD Roberto F. Machado, MD Maja Drenovac, PharmD Disclosure of Financial Interest Summary Heather R. Bream-Rouwenhorst, PharmD (faculty) has no relevant financial relationships with commercial interests. Dr Dr. Bream-Rouwenhorst Bream Rouwenhorst does not intend to discuss the off-label off label use of a product product. James C. Coons, PharmD (faculty) has no relevant financial relationships with commercial interests. Dr. Coons does not intend to discuss the off-label use of a product. Roberto F. Machado, MD (faculty) has relevant financial relationships with commercial interests as follows: Advisory Board: Gilead Sciences Grant Recipient/Research Support: NIH, Actelion, United Therapeutics Dr. Machado does intend to discuss imatinib for PAH treatment. No (other) speakers, authors, planners or content reviewers have any relevant financial relationships to disclose. No (other) speakers or authors will discuss off-label use of a product. Content review confirmed that the content was developed in a fair, balanced manner free from commercial bias. Disclosure of a relationship is not intended to suggest or condone commercial bias in any presentation, but it is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Major Issues and Challenges of Hospital Pharmacists When Managing Patients with PAH James C. Coons, PharmD, BCPS (AQ-Cardiology) Associate Professor University of Pittsburgh School of Pharmacy Department of Pharmacy and Therapeutics Pittsburg, PA 2
Current Challenges • Expansion of therapeutic options – Medications – Delivery systems • Complexity of regimens • High-risk medications • Patient acuity • Educational needs Pharmacotherapy Timeline • 1960-1980…empiric/various vasodilators • 1980… oral anticoagulants, calcium channel blockers, lung/heart transplantation • 1996… epoprostenol • 2001… bosentan • 2002… treprostinil subcutaneous (SC) • 2004… treprostinil intravenous (IV), iloprost • 2005… sildenafil • 2007… ambrisentan • 2009… tadalafil, treprostinil inhaled • 2010… thermostable epoprostenol Evaluating Prostacyclin Safety • Surveys of PAH centers – University Hospital Consortium (UHC) – Phone interview – 18 large PAH centers – Electronic ec o c su survey ey – convenience co e e ce sa sample p e oof aall PAH centers in US (n=97) Kingman MS, et al. J Heart Lung Transplant. 2010;29:841-846. 3
Page 1: ACTIVITY DESCRIPTION Target Audienc
Page 5 and 6: Examples of Medication Consideratio
Page 7 and 8: Etiology (Dana Point, 2008) 1’. P
Page 9 and 10: PAH Therapy Targets Schulze-Neick I
Page 11 and 12: Chronic Adjuvant Therapies in PAH D
Page 13 and 14: Cummulative suurvival Survival in I
Page 15 and 16: ACCF/AHA Consensus PAH Treatment Al
Page 17 and 18: Study Name Drug SUPER-1 Oral silden
Page 19 and 20: IV Epoprostenol in PAH Due to Scler
Page 21 and 22: 70 60 50 40 30 20 10 Inhaled Ilopro
Page 23 and 24: Conclusions • PAH therapy improve
Page 25 and 26: ESC/ERS Guidelines Galie N, et al.
Page 27 and 28: FUTURE DIRECTIONS WHICH MAY IMPACT
Page 29 and 30: Rationale for “Front-Loaded” Ap
Page 31 and 32: Addressing gthe Challenges g in PAH
Page 33 and 34: Considerations • Central vs. peri
Page 35 and 36: Pulmonary Hypertension • Approxim
Page 37 and 38: Example Cassette Calculations • V
Page 39 and 40: Assessment Question 1 Which of the
Page 41 and 42: Illinois Council of Health‐System
Page 43 and 44: Patient Activity ‐ 1 Patients in
Page 45 and 46: Hospitalists National Trends • Ja
Page 47 and 48: Pharmacy Landscape • PGY‐2: So
Page 49 and 50: Primary Care Physicians by Field, F
Page 51 and 52: Health Systems Pharmacy and TATAI
Page 53 and 54:
Readings The 21 Irrefutable Laws of
Page 55 and 56:
What is a “Practice Model”? •
Page 57 and 58:
Completing the Self Assessment •
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Residency trained (B23p) Illinois N
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Solving the PPMI Puzzle ‐ Here Ar
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Overview of Value Based Purchasing
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Implementation of Medication‐ rel
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Question #1 Within which programs a
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Solving the PPMI Puzzle‐ Here are
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Discharge Education/Med Rec • New
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Media‐Worthy Trials? Making Sense
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Prevention of Recurrent VTE • Unp
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VTE recurrence during study period
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Which patient might be a candidate
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Azithromycin and CV Death • Endpo
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Azithromycin and CV Death Azithromy
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Hormonal Contraception and VTE •
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• Age • Calendar year • Educa
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ARR=2.20, 2.28 for stroke, MI when
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Which of the following combinations
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3 Months of Treatment for Latent TB
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3 Months of Treatment for Latent TB
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T/F: Rifapentine in combination wit
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2. Which of the following statement
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Fitting the Counseling Piece into M
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Current Evidence: Implementing Bund
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Teach Back Process • Step 1 Expla
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Questions for Consideration and Dis
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Why do we care about ADE? • Adver
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True or False • Medication errors
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Check Point Which of the following
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Proactive Screening Process Patient
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MTI Pilot at NAH PharmD Students tr
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ASHP PPMI Case Study Adding Value:
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Interdisciplinary Teamwork: How Phy
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Highly Effective Healthcare • Wha
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Inter‐Professional Teams ‐ Chan
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Meeting the PPMI Goals for Technolo
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Drug‐Bug Mismatch Example Con’t
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Drug‐Bug Mismatch Build Rules •
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Patient Scanning Compliance Sample
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Global Immunizations 3 • Jan 2012
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Mobile Devices: Beyond Angry Birds
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Google Play • Google Play - Inter
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Other Useful Productivity Apps •
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Mobile Devices: Beyond Angry Birds
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Net Activations by Industry Source:
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News Readers/Aggregators Features S
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Contact Information • E‐mail: -
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Early‐Onset Sepsis • Sign and s
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• BR is on day 2 of cefotaxime wi
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Immunizations: The Superheroes to P
Page 161 and 162:
Current ACIP Recommendations Influe
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Herpes Zoster Vaccine Recommendatio
Page 165 and 166:
Assessment Questions 1. What are th
Page 167 and 168:
HIV Linkage and Retention in Care T
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DHHS Guidelines, March 2012: When t
Page 171 and 172:
Protease Inhibitors • Require “
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Mean Change (mg/ /dL) STARTMRK: Lip
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RAL Drug Interactions • Does not
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Instructions for Credit In order to
Page 179 and 180:
Staging Stage Criteria (Durie‐Sal
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Salvage Therapy Partial List Regime
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Bortezomib-Thalidomide-Dexamethason
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Case 2 ST is a 76 y/o African Ameri
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Thalidomide and Lenalidomide • Ad
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Fixed Low-Dose Warfarin Study Thera
Page 191 and 192:
New Drugs 2012 Anna Nowobilski‐Va
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Pulmonology » Cystic Fibrosis •
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Oncology » MTX Toxicity • MTX 1o
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NEW DRUGS AND BIOLOGICALS 2012 RESO
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Disease State Reviews for Pharmacy
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Chronic Obstructive Pulmonary Disea
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Page 205 and 206:
Green Zone • Patient is not havin
Page 207 and 208:
Page 209 and 210:
• A hormone produced by the pancr
Page 211 and 212:
Unraveling Unraveling The The Puzzl
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The Reward Center In time, serious
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So what makes addicted pharmacists
Page 217 and 218:
How to find a treatment center Onli
Page 219 and 220:
Internet Drug Abuse Study conducted
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NIAAA = best resource for alcohol d
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Impact of Postoperative Pain • Pi
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Safety Profile • Amar et al confi
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References 1. Rømsing J, Møiniche
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Society of Regional Anesthesia Meet
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A New Approach IV Acetaminophen •
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References • Schechter, Leslie N.
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Bupivacaine liposome injectable sus
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Error Potential • Inadvertent IV
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Decolonization Methods • Anti-sep
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Evidence: Inpatient ICU MRSA Coloni
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Residency Project Pearls Adherence
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650 subjects id identified tifi d R
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Overtreatment versus Appropriate Tr
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Adherence to and Outcomes Associate
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Background • Lack of comprehensiv
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Results Results‐User User Audits
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Special thanks to: • Carol Heunis
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Antibiotic Prophylaxis American Hea
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Study Limitations • Dependent on
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Study Background • Observation of
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A patient has a CrCl of 25 mL/min.
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• Cysteine hydrochloride: antioxi
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Sample Preparation • Intravenous
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Questions? Residency Project Pearls
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The Interview: Your Preparation •
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PGY1 Residency Options Carol Heunis
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RESIDENCY PROGRAM BASICS • Progra
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CV: The key to a top curriculum vit
Page 279 and 280:
Tips for a Top Notch CV • Focus o
Page 281 and 282:
What is PhORCAS? • PhORCAS is the
Page 283 and 284:
Piecing together the new CHEST guid
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Initiating therapy CHEST 2012 2.1.8
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What is “Consistently Stable?”
Page 289 and 290:
Puzzle # 2A: patient has just compl
Page 291 and 292:
What would you do for JJ? • A. Ho
Page 293 and 294:
Considerations for SB • Bleeding
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Presentation Outline ICHP Annual Meeting September 13-15

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