Presentation Outline ICHP Annual Meeting September 13-15

Results
All other things being equal…
• Progestin‐only products did not significantly
increase risk of stroke or MI
– Th These include i l d IUD and d subcutaneous b t implants i l t
• Risk of stroke was increased with vaginal ring
(Adjusted RR=2.49; 95% CI, 1.41 to 4.41) but
not patch
N Engl J Med. 2012;366(24):2257-2266.
Does type of progestin affect rates of MI and
stroke (according to this study)?
Results
Progestins with lowest risk in combo
with 30‐40 µg estrogen are of the 3rd All other things being equal…
• No difference in rates among COCs generation containing 30 to
40 µg ethinyl estradiol based on progestin type
Combined Oral Contraceptives with 30‐40 30 40 µg Estrogen
Event Risk Stroke, Adjusted RR (95% CI) MI, Adjusted RR (95% CI)
Highest
Lowest
N Engl J Med. 2012;366(24):2257-2266.
Desogestrel 2.20 (1.79‐2.69)
Norethindrone 2.17 (1.49‐3.15)
Norgestimate 1.52 (1.21‐1.91)
Drospirenone 1.64 (1.24‐2.18)
Norethindrone 2.28 (1.34‐3.87)
Desogestrel 2.09 (1.54‐2.84)
Norgestimate 1.33 (0.91‐1.94)
Drospirenone 1.65 (1.03‐2.63)
8/30/2012
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