Presentation Outline ICHP Annual Meeting September 13-15

Treatment of Latent Tuberculosis (TB)
MMWR Recomm Rep. 2003;52(RR-11):1-80.
Treatment of Latent TB
• INH treatment completion rates usually 30%
to 64%
• Efficacy important from public health
standpoint
• Concern for hepatotoxicity
• 2002 RCT showed efficacy of weekly
rifapentine and INH in continuation phase in
patients with low bacterial burden
Lancet. 2002;360(9332):528-534.
3 Months of Treatment for Latent TB
• Study Objective
– To determine if a 3‐month course of weekly
rifapentine and INH could be effective in treating
latent M tuberculosis (TB) ( )
• Methods
– Prospective, open‐label, randomized, multi‐center,
noninferiority trial
N Engl J Med. 2011;365(23):2155-2166.
8/30/2012
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