Presentation Outline ICHP Annual Meeting September 13-15

ARR=2.20, 2.28 for
stroke, MI when in
combo with 30‐40 µg
estrogen
Results
Combined Oral Contraceptives with 20 µg Estrogen
Progestin Type Stroke ARR (95% CI)
ARR=1.64, 1.65 for
MI
stroke stroke, MI when in
combo with 30‐40 µg
estrogen
Desogestrel 1.53 (1.26‐1.87) 1.55 (1.13‐2.13)
Drospirenone 0.88 (0.22‐3.53) No MIs
N Engl J Med. 2012;366(24):2257-2266.
Results
• No difference in risk between previous users
and those who had never used hormonal
contraception
• Smoking was a risk factor factor, not a confounder
N Engl J Med. 2012;366(24):2257-2266.
Does estrogen dose affect rates of MI and
stroke t k (according ( di tto this thi study)?
t d )?
8/30/2012
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