Presentation Outline ICHP Annual Meeting September 13-15

Aspirin Dose?
• 81 mg aspirin may achieve same effects as 100
mg aspirin
• 300‐325 mg no different than 75‐100 mg for
prevention of stroke stroke, MI MI, cardiovascular death
(CURRENT‐OASIS 7)
• Antiplatelet effect similar –dose‐dependent
inhibition of prostacyclin
N Engl J Med. 2010;363(10):930-942.
Strengths
• Well‐designed trial
• Appropriate diagnostic
criteria
• Appropriate length
N Engl J Med. 2012;366(21):1959-1967.
WARFASA
Limitations
• Smaller study
• Location/ethnicity
• Compliance? p
• Other medications taken
concomitantly?
• Vague descriptions for VTE
risk factors
• Majority treated with
warfarin for 12 months
WARFASA
• Use of aspirin for unprovoked VTE may be in
next CHEST guidelines
• Related trials to keep a watchful eye for:
– ASPIRE
• Similar design to WARFASA
• Inclusion: VKA for 3 months to < 12 months
• Study length: median of 3 years
– Analysis planned to combine results of WARFASA
and ASPIRE
N Engl J Med. 2012;366(21):1959-1967.
8/30/2012
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