Presentation Outline ICHP Annual Meeting September 13-15

3 Months of Treatment for Latent TB
• Interventions
– Combination therapy group (N=3986):
• Rifapentine 900 mg + INH 15‐25 mg/kg (rounded to
nearest 50 mg, max 900 mg) by mouth once weekly
given under direct observation
– Isoniazid‐only group (N=3745):
• INH 5‐15 mg/kg (rounded to nearest 50 mg, max 300
mg) by mouth daily self‐administered
• Followed for 33 months
N Engl J Med. 2011;365(23):2155-2166.
3 Months of Treatment for Latent TB
Inclusion
• High risk for progression from
latent to active TB
• Close contact of person with
confirmed TB
• Positive result on tuberculin
skin test
• HIV and positive tuberculin
test, or negative if close
contact
• CXR consistent with previously
untreated TB
N Engl J Med. 2011;365(23):2155-2166.
Exclusion
• Confirmed TB
• Resistance to INH or rifampin
(in source case)
• Tx with rifamycin or INH in
past 2 years
• Previous TB Tx
• AST 5x ULN
• HIV Tx within 90 days after
enrollment
3 Months of Treatment for Latent TB
• Primary endpoint
– Culture‐confirmed TB in patients >18 years
– Culture‐confirmed or clinical TB in patients