Presentation Outline ICHP Annual Meeting September 13-15

Stability of Intravenous Acetaminophen (10 mg/mL) at Room
Temperature in Varying Storage Containers
Sample Actual Initial
Drug
Concentrationa (mg/mL)
100 mg
(syringe)
250 mg
(syringe)
500 mg
(syringe)
250 mg
(bottle)
900 mg
(bottle)
% Initial Concentration Remaining
24 hours 48 hours 72 hours 84 hours
9.94 ± 0.05 99.11 ± 0.52 100.54 ± 0.69 100.08 ± 0.38 100.02 ±0.53
9.96 ± 0.02 99.66 ± 1.11 99.61 ± 0.68 99.83 ± 0.89 99.80 ±0.35
9.96 ± 0.03 100.13 ± 0.37 99.83 ± 0.64 99.92 ± 058 99.68 ±0.55
9.98 ± 0.03 99.67 ± 0.36 100.07 ± 1.26 99.37 ± 0.24 99.53 ±0.41
9.93 ± 0.04 99.76 ± 0.33 100.03 ± 0.59 100.54 ± 0.58 100.31 ±1.22
a Mean ±S.D. of duplicate determinants for three samples (n = 3).
Conclusion
• Intravenous acetaminophen (10 mg/mL) was
physically and chemically stable in a range of volumes
for up to 84 hours in the opened bottles and in
polypropylene syringes
References
1. Babl FE, Theophilos T, Palmer GM. Is there a role for intravenous
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6. OFIRMEV (intravenous acetaminophen) package insert. San Diego, CA:
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Results
• No detectable change in sample color
• No visible drug precipitation
• No appreciable change in the initial pH (5.77 ±0.02)
• Interday coefficient of variation: 1.8%
• Intraday coefficient of variation: 1%
Significance
• Benefits of extending the stability of
intravenous acetaminophen
– Decreased product waste
– Cost savings to patients and the healthcare system
– Pharmacy workflow optimized by minimizing need
for urgent dose preparation
References
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American Pharmacists Associations. 5th ed. London; Pharmaceutical
Press; 2006.
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102.
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National Formulary, 29th ed. Rockville, MD: United States Pharmacopeial
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8/29/2012
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