Presentation Outline ICHP Annual Meeting September 13-15

Results
Adjusted RRs for Events with COCs Based on Estrogen Dose
N Engl J Med. 2012;366(24):2257-2266.
50 µg: S, 1.97 and MI, 3.73
30‐40 µg: S, 1.75 and MI, 1.88
20 µg: S, 1.60 and MI, 1.40
Stroke, MI, and
Hormonal Contraception
Strengths
Limitations
• Large amount of data • Study design
• Valid Rx detail
• Accuracy of
• Sensitivity y analysis y
database/coding
performed • Some subgroups smaller
• Danish population
Stroke, MI, and
Hormonal Contraception
Overall Conclusion
• Estrogen dose of 30‐40 µg combined with
progestin correlated to a risk of arterial event
13to 1.3 to 2.3 23times times higher than nonusers
• Estrogen dose of 20 µg had risk of 0.9 to 1.7
times higher than nonusers
• Only small differences among progestins
• Arterial events not as frequent as VTE with
hormonal contraception
8/30/2012
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