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world cancer report - iarc

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Fig. 5.134 Ten-year relative survival for melanoma,<br />

according to stage.<br />

nique enables mapping of the lymphatics<br />

in the skin by lymphoscintigraphy:<br />

radioactive tracer is injected at the site of<br />

the primary and its flow through the skin<br />

to the first lymph node that takes up the<br />

REFERENCES<br />

1. Ferlay J, Bray F, Parkin DM, Pisani P (2001) Globocan<br />

2000: Cancer Incidence and Mortality Worldwide (IARC<br />

Cancer Bases No. 5), Lyon, IARCPress.<br />

2. IARC (1992) Solar and Ultraviolet Radiation (IARC<br />

Monographs on the Evaluation of Carcinogenic Risks to<br />

Humans, Vol. 55), Lyon, IARCPress.<br />

3. Aitken JF, Duffy DL, Green A, Youl P, MacLennan R,<br />

Martin NG (1994) Heterogeneity of melanoma risk in families<br />

of melanoma patients. Am J Epidemiol, 140: 961-973.<br />

4. Steiner A, Pehamberger H, Wolff K (1987) In vivo epiluminescence<br />

microscopy of pigmented skin lesions. II.<br />

Diagnosis of small pigmented skin lesions and early detection<br />

of malignant melanoma. J Am Acad Dermatol, 17: 584-<br />

591.<br />

5. Schaffer JV, Bolognia JL (2001) The melanocortin-1<br />

receptor: red hair and beyond. Arch Dermatol, 137: 1477-<br />

1485.<br />

6. Pollock PM, Trent JM (2000) The genetics of cutaneous<br />

melanoma. Clin Lab Med, 20: 667-690.<br />

7. Goldstein AM, Chidambaram A, Halpern A, Holly EA,<br />

Guerry ID, Sagebiel R, Elder DE, Tucker MA (2002) Rarity of<br />

CDK4 germline mutations in familial melanoma. Melanoma<br />

Res, 12: 51-55.<br />

256 Human <strong>cancer</strong>s by organ site<br />

tracer (the sentinel node) is identified.<br />

This lymph node is then removed for<br />

histopathological examination; only patients<br />

with positive lymph nodes are subjected<br />

to full lymph node dissection.<br />

However, pending completion of an international<br />

trial, the survival benefit of this<br />

technique is unknown.<br />

Metastatic melanoma<br />

The greater the number of nodes involved,<br />

the higher the risk of systemic metastases<br />

and poor prognosis. As the thickness of the<br />

melanoma increases and as the number of<br />

lymph nodes involved rises, the risk of systemic<br />

metastases becomes greater.<br />

Melanoma metastasizes widely, with the<br />

lungs, liver and brain being the most common<br />

sites. Vitiligo (a skin condition characterized<br />

by failure to form melanin) is a<br />

favourable prognostic sign in metastatic<br />

melanoma. At the present time, only a small<br />

8. Halachmi S, Gilchrest BA (2001) Update on genetic<br />

events in the pathogenesis of melanoma. Curr Opin Oncol,<br />

13: 129-136.<br />

9. Davies H, Bignell GR, Cox C, Stephens P, Edkins S et<br />

al. (2002) Mutations of the BRAF gene in human <strong>cancer</strong>.<br />

Nature, 417: 949-954.<br />

10. National Health and Medical Research Council, ed.<br />

(1999) Clinical Practice Guidelines. The Management of<br />

Cutaneous Melanoma.<br />

11. Morton DL (2001) Lymphatic mapping and sentinel<br />

lymphadenectomy for melanoma: past, present and future.<br />

Ann Surg Oncol, 8: 22S-28S.<br />

12. Coates AS (1992) Systemic chemotherapy for malignant<br />

melanoma. World J Surg, 16: 277-281.<br />

13. Helmbach H, Rossmann E, Kern MA, Schadendorf D<br />

(2001) Drug-resistance in human melanoma. Int J Cancer,<br />

93: 617-622.<br />

14. Weber JS, Aparicio A (2001) Novel immunologic<br />

approaches to the management of malignant melanoma.<br />

Curr Opin Oncol, 13: 124-128.<br />

15. Hersey P (2002) Advances in the non-surgical treatment<br />

of melanoma. Expert Opin Investig Drugs, 11: 75-85.<br />

proportion of people (

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