Asbestos Fibers and Other Elongate Mineral Particles: State of the ...

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CURRENT INTELLIGENCE BULLETIN 62 As
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CURRENT INTELLIGENCE BULLETIN 62 As
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Foreword Asbestos has been a highly
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Executive Summary In the 1970s, NIO
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NIOSH recognizes that its 1990 desc
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of exposure to various types of EMP
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xii 2.9.3 Biopersistence and other
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xiv List of Figures Figure 1. U.S.
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xvi MAPK mitogen-activated protein
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xviii Brooke Mossman, PhD Universit
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controlled, even when exhaustive lo
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2 Overview of Current Issues 2.1 Ba
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juxtaposition or matrixed together,
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A further source of confusion comes
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Figure 2. Asbestos: Annual geometri
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Figure 3. Number of asbestosis deat
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at home by playing in areas where a
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physician from an occupational and
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of airborne asbestos fibers was fir
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which the deposits have been report
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with the most pronounced excess of
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A limitation of the epidemiological
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CI = 1.8-6.7) was noted in the earl
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exposure to commercial asbestos, an
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of these populations should be purs
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affect only a small number of obser
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exposed to fibers considerably long
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the extent to which the material ha
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or statistical power to permit a co
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capillaries, whereas insoluble part
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mechanisms and increase the rate of
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can penetrate their interior to pro
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A review for the EPA by an internat
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2.9.4.3.1 Reactive Oxygen Species A
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of different types of mineral parti
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secreted by mesothelial cells after
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direct oxidant production, exposure
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widths are greater for the prismati
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concluded that asbestos fibers
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crystal structure, and surface comp
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is calibrated appropriately for NIO
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is made of an area larger than a si
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data are needed to more fully asses
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70 III. Develop improved sampling a
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the current paradigm because their
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on the development of disease endpo
Page 96 and 97: esponse, and time-course data would
Page 98 and 99: In the second phase of cellular res
Page 100 and 101: 80 • Investigate mechanisms of EM
Page 102 and 103: Research is needed to produce infor
Page 104 and 105: periods that characterize manifesta
Page 106 and 107: children in tow, placing both sexes
Page 108 and 109: 88 • Develop, validate, and promo
Page 110 and 111: elevant, then an exposure assessmen
Page 112 and 113: ased on counts made by the current
Page 114 and 115: established precedence in applying
Page 116 and 117: the mechanisms by which asbestos fi
Page 119 and 120: 4 The Path Forward Developing an in
Page 121 and 122: surveillance investigations. By hav
Page 123 and 124: 5 References Aadchi S, Yoshida S, K
Page 125 and 126: Berman DW, Crump KS [2008b]. A meta
Page 127 and 128: mineral fiber number and epidemiolo
Page 129 and 130: the United States, 1968-81. J Natl
Page 131 and 132: Greim HA [2004]. Research needs to
Page 133 and 134: France: International Agency for Re
Page 135 and 136: millers in New York State. Arch Env
Page 137 and 138: Mandel J (mand0125@umn.edu) [2008].
Page 139 and 140: gpo.gov/2008/pdf/E8-3828.pdf]. Date
Page 141 and 142: Pneumoconioses to Digital Chest Rad
Page 143 and 144: Potter RM [2000]. Method for determ
Page 145: glass: pleural response in the rat
Page 149: Yano E, Wang Z, Wang X [2001]. Canc
Page 152 and 153: efficiency, regardless of sampler o
Page 154 and 155: Table 1. Definitions of general min
Page 166 and 167: Table 2. Definitions of specific mi
Page 174: safer • healthier • people tm D
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