- Page 1: CURRENT INTELLIGENCE BULLETIN 62 As
- Page 5 and 6: Foreword Asbestos has been a highly
- Page 7 and 8: Executive Summary In the 1970s, NIO
- Page 9 and 10: NIOSH recognizes that its 1990 desc
- Page 11: of exposure to various types of EMP
- Page 14 and 15: xii 2.9.3 Biopersistence and other
- Page 16 and 17: xiv List of Figures Figure 1. U.S.
- Page 18 and 19: xvi MAPK mitogen-activated protein
- Page 20 and 21: xviii Brooke Mossman, PhD Universit
- Page 22 and 23: controlled, even when exhaustive lo
- Page 25 and 26: 2 Overview of Current Issues 2.1 Ba
- Page 27 and 28: juxtaposition or matrixed together,
- Page 29 and 30: A further source of confusion comes
- Page 31 and 32: Figure 2. Asbestos: Annual geometri
- Page 33 and 34: Figure 3. Number of asbestosis deat
- Page 35 and 36: at home by playing in areas where a
- Page 37 and 38: physician from an occupational and
- Page 39 and 40: of airborne asbestos fibers was fir
- Page 41 and 42: which the deposits have been report
- Page 43 and 44: with the most pronounced excess of
- Page 45 and 46: A limitation of the epidemiological
- Page 47 and 48: CI = 1.8-6.7) was noted in the earl
- Page 49 and 50: exposure to commercial asbestos, an
- Page 51 and 52: of these populations should be purs
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affect only a small number of obser
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exposed to fibers considerably long
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the extent to which the material ha
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or statistical power to permit a co
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capillaries, whereas insoluble part
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mechanisms and increase the rate of
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can penetrate their interior to pro
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A review for the EPA by an internat
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2.9.4.3.1 Reactive Oxygen Species A
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of different types of mineral parti
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secreted by mesothelial cells after
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direct oxidant production, exposure
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widths are greater for the prismati
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concluded that asbestos fibers
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crystal structure, and surface comp
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is calibrated appropriately for NIO
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is made of an area larger than a si
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data are needed to more fully asses
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70 III. Develop improved sampling a
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the current paradigm because their
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on the development of disease endpo
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esponse, and time-course data would
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In the second phase of cellular res
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80 • Investigate mechanisms of EM
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Research is needed to produce infor
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periods that characterize manifesta
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children in tow, placing both sexes
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88 • Develop, validate, and promo
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elevant, then an exposure assessmen
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ased on counts made by the current
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established precedence in applying
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the mechanisms by which asbestos fi
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4 The Path Forward Developing an in
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surveillance investigations. By hav
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5 References Aadchi S, Yoshida S, K
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Berman DW, Crump KS [2008b]. A meta
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mineral fiber number and epidemiolo
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the United States, 1968-81. J Natl
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Greim HA [2004]. Research needs to
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France: International Agency for Re
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millers in New York State. Arch Env
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Mandel J (mand0125@umn.edu) [2008].
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gpo.gov/2008/pdf/E8-3828.pdf]. Date
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Pneumoconioses to Digital Chest Rad
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Potter RM [2000]. Method for determ
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glass: pleural response in the rat
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Vianna NJ, Maslowsky J, Robert S, S
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Yano E, Wang Z, Wang X [2001]. Canc
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efficiency, regardless of sampler o
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Table 1. Definitions of general min
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Table 1. Definitions of general min
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Table 1. Definitions of general min
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Table 1. Definitions of general min
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Table 1. Definitions of general min
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Table 1. Definitions of general min
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Table 2. Definitions of specific mi
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Table 2. Definitions of specific mi
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Table 2. Definitions of specific mi
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Table 2. Definitions of specific mi
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safer • healthier • people tm D