3+ 4/2002 - Společnost pro pojivové tkáně

SUMMARY
PŮVODNÍ PRÁCE ● ORIGINAL PAPER
ÚČINNOST KOLAGENNÍCH PEPTIDŮ
VS. DICLOFENAC U KOSTNÍ FORMY
OSEOARTHRITIDY
EFFICACY OF COLLAGEN PEPTIDES
VS. DICLOFENACUM NATRICUM IN BONE FORM
OSTEOARTHRITIS
ADAM M., HULEJOVÁ H., ‚PAČEK J.
Institute of Rheumatology, Prague, Czechia
Objective: The clinical efficacy of pharmaceutical grade of collagen hydrolysate (PCH)
on osteoarthritic troubles was compared with that of the nonsteroidal antiinflammatory
drug diclofenac (DC) in a short term clinical study in patients with bone form of hip and/or
knee joint osteoarthritis (OA) (III. or IV. grade according to Kellgren and Lawrence, 1957).
Methods: This is a double-blind, randomized, parallel group study. 46 patients were
recruited into three groups. From those the trial finished 44 subjects, patients received all
the substances in sachets for three months: 15 patients 10 g PCH/day, 13 patients 75 mg
DC/day and 16 patients 10 g PCH and 75 mg DC together in one sachet/day. Clinical efficacy
was evaluated by assesing the Lequesne Index, spontaneous and on load pains observed
(using 3 point ordinal scale).
Results: Lequesne Index decreased in all the three treatments already after one month
therapy with far greater down regulation observed in the DCF group (to 29.74 % of the baseline).
In the PCH group the Index dropped down to 66.42 % of baseline. In both the PCH
groups Index improved defititely during the trial. The Index in the follow-up examination
(visit 5) increased for the DCF monotreatment and reached values close to the baseline
(16.31 versus 15.31). Patients treated with PCH only exhibited the therapeutic effect later
on in time but it lasted at least for up 3 month after the treatment was withdrawn. Patients
treated with DCF showed prompt and plain reduction of clinical symptoms, which nevertheless
reappeared when treatment was withdrawn. Subjects with PCH consumpted paracetamol
exceptional only, those treated with DCF did not used it at all. Urinary pyridinolines
and bone alkaline phosphatase did not exhibit any recognizable trends. At the end of the
threemonth treatment phase, the chondrex score showed a definite improvement in PCH
group.
POHYBOVÉ ÚSTROJÍ, ročník 9, 2002, č. 3+4 61