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Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

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animals during RVF outbreaks <strong>or</strong> collect d<strong>or</strong>mant Aedes RVF virus infected eggs from soils<br />

in endemic countries. Even though transp<strong>or</strong>t and w<strong>or</strong>k with RVF virus is closely regulated,<br />

terr<strong>or</strong>ists conceivably could obtain the pathogen by illegitimate means from research<br />

lab<strong>or</strong>at<strong>or</strong>ies (within the United States, in non-endemic European countries, <strong>or</strong> in endemic<br />

countries) that house invent<strong>or</strong>ies <strong>of</strong> the virus (K<strong>or</strong>tepeter et al. 2001).<br />

Many experts agree that smuggling <strong>of</strong> live RVF virus into the United States is<br />

feasible (Kasari et al. 2008). As rep<strong>or</strong>ted by Kasari et al. 2008, “there are 152 international<br />

airp<strong>or</strong>ts and 170 sea <strong>or</strong> river p<strong>or</strong>ts <strong>of</strong> call in the United States, all <strong>of</strong> which are potential entry<br />

pathways f<strong>or</strong> humans who wish to illicitly transp<strong>or</strong>t RVF virus.” The threat is compounded<br />

by the fact that it is difficult to screen passengers and easy to hide the virus.<br />

Once in the United States, terr<strong>or</strong>ists potentially could cause a RVF outbreak by<br />

infecting local mosquitoes with the virus, placing d<strong>or</strong>mant Aedes RVF virus infected eggs in<br />

a suitable environment, introducing an infected animal within livestock herds, <strong>or</strong> releasing<br />

the virus as an aerosol targeted at humans, livestock <strong>or</strong> wildlife.<br />

2.2.2 FACTORS THAT AFFECT RIFT VALLEY FEVER ESTABLISHMENT AND SPREAD<br />

Regardless <strong>of</strong> whether RVF were to emerge in the United States naturally <strong>or</strong> by<br />

intentional means, amplification <strong>of</strong> the virus would be required f<strong>or</strong> the disease to result in an<br />

epidemic, become established, and spread. Virus amplification depends on numerous fact<strong>or</strong>s,<br />

including prevalence <strong>of</strong> competent vect<strong>or</strong>s, proximity and susceptibility <strong>of</strong> amplifying<br />

vertebrate hosts, and presence <strong>of</strong> environmental conditions suitable f<strong>or</strong> virus transmission by<br />

competent vect<strong>or</strong>s (House et al. 1992, Chevalier et al. 2004a).<br />

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