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CONFIDENTIAL
Regulatory Affairs &
Nutrition Communication – AJ/Se
28 May 2008
Page 5 of 16
(250ml) and biscuits (140g) for breakfast after overnight fasting, followed by hourly
collection of the ileostoma bags over an 8-hour period. On average, 96% (drinks) or 99%
(drinks + biscuits) of the 50g isomaltulose intake was digested (hydrolysed), and 94%
(drinks) or 96% (drinks + biscuits) was absorbed in the small intestine. There was no
significant effect of the food type. This study confirms that isomaltulose is a fully digestible
carbohydrate.
Its gastrointestinal tolerance is similar to sucrose
While low-digestible carbohydrates are known to have the potential to cause
gastrointestinal discomfort as they are osmotically active and fermented in the large
intestine to short chain fatty acids and gases, isomaltulose shows a slow but virtually
complete absorption and is therefore tolerated well, similar to sucrose.
In conclusion, the totality of in vitro and in vivo data shows that isomaltulose is a
well tolerated carbohydrate that is absorbed slowly but virtually completely in form
of glucose and fructose.