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CONFIDENTIAL Regulatory Affairs & Nutrition Communication – AJ/Se 28 May 2008 Page 14 of 16 5. Conclusion Isomaltulose is a ‘slow release carbohydrate’. Due to its digestion properties, isomaltulose is a well tolerated ‘available carbohydrate’. It is a glucose provider for the body and an energy provider as well, supplying glucose at a lower level (avoiding pronounced hyperglycaemic and hypoglycaemic phases) for a prolonged time compared to sucrose. Isomaltulose is low glycemic and low insulinemic whilst providing the same total calories as sucrose. Having these physiological properties in mind, isomaltulose is a carbohydrate for people following a healthy and active lifestyle. Isomaltulose is a useful tool to bring a carbohydrate-based low-glycemic diet into practice.
CONFIDENTIAL References Regulatory Affairs & Nutrition Communication – AJ/Se 28 May 2008 Page 15 of 16 Augustin, L.S., Franceschi, S., Jenkins, D.J.A., Kendall, C.W.C. , La Vecchia, C. (2002) Glycemic index in chronic disease - a review. Eur J Clin Nutr 56, 1049-1071. Brand-Miller, J., Wolever, T.M.S., Colagiuri, S., Foster-Powell, K. (1999) The Glucose Revolution. Marlow and Company, New York. Brand-Miller, J., Wolever, T.M.S., Colagiuri, S., Foster-Powell, K. (1999) The Glucose Revolution. Marlow and Company, New York. Brand-Miller, J., Hayne, S., Petocz, P., Colagiuri, S. (2003) Low glycemic index diets in the management of diabetes: a meta-analysis of randomised controlled trials. Diabetes Care 26, 2261-2267. Dahlqvist, A. (1961) Hydrolysis of Palatinose (isomaltulose) by pig intestinal glycosidases. Acta Chem Scan 15, 808-816. Dahlquist, A., Auricchio, S., Semenza, G., Prader,A. (1963) Human intestinal disaccharidases and heriditary disaccaride intolerance. The hydrolysis of sucrose, isomaltulose, Palatinose (isomaltulose) and a 1,6-α-oligosaccharide (isomalto-oligosaccharide) preparation. J Clin Invest, 42, 556-562. Eggleston, G., Grisham, M. (2003) Oligosacchrides in cane and their formation on cane deterioration. In: ACS Symposium Series 849,Chapter 16, 211-232. EU Commission Decision 2005/581/EC of 25 th July 2005 authorising the placing on the market of isomaltulose as a novel food or novel food ingredient under Regulation (EC) No 258/97of the European Parliament and of the Council. Official Journal of the European Union of 29.7.2005, L199/90 – 91. FAO/WHO (1998) Carbohydrates in human nutrition. In FAO Nutrition Paper No.66. Rome, FAO. FDA (2006) – US GRAS Notification No 0184 on isomaltulose. Gostner, A., Holub, S., Theis, S., Volk, A., Kozianowski, G., Scheppach, W. (2006) Intestinal digestibility of isomaltulose (Palatinose) in patients with ileostoma [Intestinale Verdaulichkeit von Palatinose bei Patienten mit Ileostoma]. Z. Gastroenterol 44, 1073-1094. [Abstract P 18; poster presented at the 34 th Congress of the German Society of Gastroenterology (Gesellschaft für Gastroenterologie), 26.- 28.10.2006, Rosenheim]. Grupp, U., Siebert, G. (1978) Metabolism of hydrogenated isomaltulose, an equimolar mixture of alpha-Dglucopyranosido-1,6-sorbitol and alpha-D-glucopyranosido-1,6-mannitol. Res Exp Med (Berl.) 173, 261- 278. Günther, S., Heymann, H. (1998) Di- and oligosaccharide substrate specificities and subsite binding energies of pig intestinal glucoamylase-maltase. Arch Biochem Biophys 354, 111-116. Heinz, F. (1987) Enzymatische Spaltung von Zuckeraustauschstoffen durch isolierte Enzyme und Enzymkomplexe der Dünndarmmukosa. Medizinische Hochschule Hannover, Zentrum Biochemie, Universität Hannover, Forschungsvorhaben 6539. Heymann, H., Heinz,F. (1987) Kinetic studies on glucoamylase/maltase and sucrase/isomaltase complex of human, pig and rat intestinal mucosa. 4 th European Carbohydrate Symposium, Darmstadt, (12.- 17.07.87). Jenkins, D.J.A., Kendall, C.W.C., Augustin, L.S.A., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A.L., Axelsen, M. (2002) Glycemic index: overview of implications in health and disease. Am J Clin Nutr 76, 266S-273S.
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Comision Federal de la mejora regul
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Subject: MEXICO - Comments on PROY
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Item of PROY‐ NOM‐051 A.3.1 & A
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Annex 1.1: Ziesenitz, S.C.; 1996;
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Volume 61 Supplement 1 December 200
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Volume 61, Supplement 1, December 2
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S1 S5 S19 S40 S75 S100 S112 S122 S1
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FAO/WHO Scientific Update on carboh
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cardiovascular diseases and cancer)
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REVIEW Carbohydrate terminology and
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Table 2 Energy and macronutrient in
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are inulin and fructo oligosacchari
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Table 3 Principal physiological pro
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National Academy of Sciences in 200
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product contained X25% whole grain
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Henderson L, Gregory J, Swan G (200
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REVIEW Nutritional characterization
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Table 1 Nutritional characterizatio
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Table 2 Principles of carbohydrate
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Table 4 NSP in a selection of foods
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asked to consider both the ‘plant
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Table 5 Continued Plant-rich diet a
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account for any supplemented materi
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eaction vessels, with successive tr
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similar to the situation with sugar
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company working on dietary carbohyd
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van Dam RM, Seidell JC (2007). Carb
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2003). In establishing the energy v
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combustible energy of the fermentab
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glucose, starch, NSP) there is also
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generated through bioenergetic inef
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Table 4 cE, ME and NME, and content
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ME (Atwater general system) (Merill
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(o0.8 kg in the adult), increase af
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B1.4 MJ from protein in men, did no
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food and body weight, height or BMI
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esults may relate not only to the d
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ecologist, who is pre-occupied with
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Table 5 Effect of NSP (dietary fibr
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As already described, almost any ca
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in adolescents. Possible mechanisms
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unit, such as a grant or fellowship
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Conference on Medical Research. Ros
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Prentice AM, Poppitt SD (1996). Imp
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REVIEW Carbohydrate intake and obes
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Total carbohydrate intake Introduct
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composition of the diet did not sub
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European Journal of Clinical Nutrit
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postmenopausal US women (Howard et
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weight loss was greater after 6 mon
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European Journal of Clinical Nutrit
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its carbohydrate content, whereas a
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Table 4 Continued Duration Interven
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Despite a substantially lower GL fo
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increased physical activity has bee
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with normal glucose tolerance: the
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Westerterp KR, Verboeket-van de Ven
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especially the NSP, complicates com
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1.21, 1.35, 1.40 and 1.64. The patt
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esidual confounding provide the jus
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carbohydrate have generated broadly
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There is no good evidence of benefi
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Meyer KA, Kushi LH, Jacobs Jr DR, S
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from prospective studies which have
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Table 3 Prospective studies of diet
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of sucrose-containing foods, such a
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Page 187 and 188: CONFIDENTIAL Regulatory Affairs & N
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5 Nutrition and Health Claims (CAC/
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Annex 3.2: “Letter of no objectio
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