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Low_resolution_Thesis_CDD_221009_public - Visual Optics and ...

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INTRODUCTION<br />

corneal surface may be expected, since the surgery weakens the cornea (see Fig. 1.21).<br />

As corneal biomechanical properties are largely unknown, it is not possible to predict<br />

theoretically the extent of this potential deformation (Dupps <strong>and</strong> Wilson, 2006).<br />

Fig. 1.21. From (Dupps <strong>and</strong> Wilson, 2006). Major biomechanical loading forces in<br />

the cornea <strong>and</strong> a model of biomechanical central flattening associated with disruption<br />

of central lamellar segments. According to Roberts (Roberts, 2000, Roberts, 2002), a<br />

reduction in lamellar tension in the peripheral stroma reduces resistance to swelling<br />

<strong>and</strong> an acute expansion of peripheral stromal volume results. Interlamellar cohesive<br />

forces (Smolek, 1993) <strong>and</strong> collagen interweaving, whose distribution is greater in the<br />

anterior <strong>and</strong> peripheral stroma <strong>and</strong> is indicated by grey shading, provide a means of<br />

transmitting centripetal forces to underlying lamellae. Because the central portions of<br />

these lamellae constitute the immediate postoperative surface, flattening of the optical<br />

surface occurs, resulting in hyperopic shift.<br />

1.7.5. Current trends in refractive surgery<br />

Refractive surgery has been improved over the past years, thanks to the refinement of<br />

the involved technologies <strong>and</strong> the improvement in the ablation pattern design.<br />

Presumably, the improvements of the ablation patterns with the estimated correction<br />

factors obtained theoretically are now included in the proprietary ablation algorithms<br />

of most laser platforms, which are now most likely compensated for efficiency effects.<br />

The final goal of refractive surgery is the possibility for correction of higher optical<br />

aberrations of the eye, <strong>and</strong> not only conventional refractive errors. Most laser<br />

manufacturers claim that current ablation algorithms are now wavefront-optimized or<br />

customized to the patients’ optical aberrations (aspheric, wavefront-guided or<br />

topography-guided) (Kohnen, 2006, Kohnen, 2008), with the aim of avoiding the<br />

increase of spherical aberration that was a major issue with st<strong>and</strong>ard ablation profiles<br />

(Moreno-Barriuso et al., 2001b, Marcos et al., 2001a). Customized wavefront guided<br />

surgery is assisted by wavefront sensors <strong>and</strong> topographers (to measure optical<br />

aberrations) <strong>and</strong> precise lasers provided with precise control of the energy delivery at<br />

each point, thanks to flying spot technology, pupil tracking, <strong>and</strong> fast repetition rates.<br />

Femtosecond laser technology allows for flap creation that induces less change in<br />

high-order aberrations <strong>and</strong> corneal biomechanics (Kim <strong>and</strong> Chuck, 2008).<br />

Recent studies (Arba-Mosquera <strong>and</strong> de Ortueta, 2008, Kwon et al., 2008) describe<br />

sophisticated numerical models that take into account most of the knowledge gathered<br />

in the last years on the physical effects affecting refractive surgery (in particular some<br />

of the results of this thesis), with less approximations, <strong>and</strong> considering the temporal<br />

49

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