Friday <strong>AM</strong> 11:30 769. Comparative Oxidative Demands in Cortex & Subcortex Revealed By High Field Calibrated fMRI Basavaraju G. Sanganahalli 1,2 , Peter Herman 1,2 , Douglas L. Rothman 2,3 , Hal Blumenfeld 2,4 , Fahmeed Hyder 2,3 1 Diagnostic Radiology, Yale University, New Haven, CT, USA; 2 Quantitative Neuroscience with Magnetic Resonance in Medicine (QNMR), Yale University, New Haven, CT, USA; 3 Diagnostic Radiology & Biomedical Engineering, Yale University, New Haven, CT, USA; 4 Neurology, Neurosurgery, Neuroscience, Yale University, New Haven, CT, USA 11:42 770. The Ratio of CBF to CMRO 2 Change with Brain Activation Remains Unchanged between Simple & Complex Stimuli in the Human Visual Cortex Valerie Griffeth 1 , Richard Buxton 2 1 Department of Bioengineering, UC San Diego, La Jolla, CA, USA; 2 Department of Radiology, UC San Diego, La Jolla, CA, USA 11:54 771. Calibration & Validation of TRUST MRI for the Estimation of Cerebral Blood Oxygenation Hanzhang Lu 1 , Feng Xu 1 , Ksenija Grgac 2,3 , Peiying Liu 1 , Qin Qin 2,3 , Peter van Zijl 2,3 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2 Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; 3 F.M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, USA 12:06 772. A Generalized Procedure for Calibrated MRI Incorporating Hyperoxia & Hypercapnia Claudine Joëlle Gauthier 1 , 2 , Richard D. Hoge 1 , 2 1 Physiology/Biomedical Engineering, Université de Montréal, Montreal, Quebec, Canada; 2 CRIUGM, Montreal, Quebec, Canada 12:18 773. Evolution of the Dynamic Changes in Cerebral Oxidative Metabolism Evoked by Somato-Sensory Stimulation Alberto L. Vazquez 1 , Mitsuhiro Fukuda 1 , Seong-Gi Kim 1 1 Radiology, University of Pittsburgh, Pittsburgh, PA, USA Normal Aging Brain Room 710A 10:30-12:30 Moderators: Christopher P. Hess & Patrik Zamecnik 10:30 774. Age Effects on the Amplitude & Frequency of Resting-State BOLD Fluctuations J. Jean Chen 1,2 , Tyler D. Triggs 1 , H. Diana Rosas 1,3 , David H. Salat 1,2 1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2 Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; 3 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA 10:42 775. Association between Cerebral Blood Flow & Age-Related Changes in White Matter Microstructure J. Jean Chen 1,2 , H. Diana Rosas 1,3 , David H. Salat 1,2 1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2 Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; 3 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA 10:54 776. Aging Effect on Human Brain Transverse Relaxation Since Preadolescence Jianli Wang 1 , Megha Patel 1 , Deborah Dossick 1 , Michele L. Shaffer 2 , Christopher W. Weitekamp 1 , Xiaoyu Sun 1 , Jeffrey Vesek 1 , Paul J. Eslinger 3 , David J. Jill 3 , James R. Connor 4 , Qing X. Yang 1,4 1 Radiology, Penn State College of Medicine, Hershey, PA, USA; 2 Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA; 3 Neurology, Penn State College of Medicine, Hershey, PA, USA; 4 Neurosurgery, Penn State College of Medicine, Hershey, PA, USA 11:06 777. Genetic Influences on White Matter Microstructure in 280 Twins Scanned with 4 Tesla High Angular Resolution Diffusion Imaging (HARDI) Agatha D. Lee 1 , Natasha Lepore 2 , Caroline C. Brun 3 , Marina Barysheva, Arthur Toga, Katie L. McMaho 4 , Greig I. de Zubicaray 5 , Nicholas G. Martin, Margaret Wright, Paul M. Thompson 1 Neurology, LONI-UCLA, Los Angeles, CA, USA; 2 CHLA -USC; 3 UPENN; 4 Centre for Magnetic Resonance, University of Queensland; 5 Queensland Institute of Medical Research, 11:18 778. Preliminary Evidence of Increased Brain Acetate Uptake & Oxidation in Heavy Drinkers Probed by 13 C-MRS Lihong Jiang 1 , Barbara Gulanski 2 , Stuart Weinzimer 3 , Ismene Petrakis 3 , Elizabeth Guidone 3 , Julia Koretski 3 , Graeme Mason 1 Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA; 2 Internal Medicine, Yale University School of Medicine; 3 Psychiatry, Yale University School of Medicine 11:30 779. Age & Gender Related Alterations in Brain Perfusion Dynamics Yinan Liu 1,2 , Xiaoping Zhu 1 , David Feinberg 2,3 , Matthias Guenther 4,5 , Howard Rosen 6 , Michael W. Weiner 1,2 , Norbert Schuff 1,2 1 Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA; 2 Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA; 3 Advanced MRI Technology 106
Friday <strong>AM</strong> LLC, Sebastopol, CA, USA; 4 Mediri GmbH, Heidelberg, Germany; 5 Department of Neurology, Klinikum Mannheim, University Heidelberg, Mannheim, Germany; 6 Department of Neurology, University of California, San Francisco, CA, USA 11:42 780. Regional Changes of Cortical Mean Diffusivity with Ageing & Alzheimer Disease after Correction of Partial Volume Effects Tina Jeon 1 , Virendra Mishra 1 , Myron Weiner 2 , Kristin Martin-Cook 3 , Kimmo Hatanpaa 4 , Chan Foong 4 , Hao Huang 1 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2 Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; 3 Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 4 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA 11:54 781. Effect of Aging on CBF Mapping of Default Mode Network : An fMRI Study Ying Hao 1 , Jing Liu 2 , Yue Zhang 3 , Xiaoying Wang 1,4 , Jue Zhang 1,3 , Jing Fang 3,5 1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of; 2 Dept. of Radiology, Peking University First Hospital, Beijing, China, People's Republic of; 3 College of Engineering, Peking University, Beijing, China, People's Republic of; 4 Dept. of Radiology, Peking University First Hospital, Beijing, Beijing, China, People's Republic of; 5 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of 12:06 782. Multi Modal MRI Reveals Early Life Brain Changes in Human Apoe-Ε4 Carriers Ory Levy 1 , Anat Bar-Shira 2 , Avi Orr-Urtreger 2,3 , Yaniv Assaf 1 1 Department of Neurobiology, Life Sciences Faculty, Tel aviv University, Tel Aviv, Israel; 2 The Genetic Institute, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; 3 The Sackler Faculty of Medicine, Tel aviv University, Tel Aviv, Israel 12:18 783. Paradoxically Reduced Cerebral Vascular Reactivity in Masters Athletes Binu P. Thomas 1,2 , Uma Sreekumar Yezhuvath 1 , Rong Zhang 3,4 , Benjamin Yichen Tseng 3,4 , Benjamin Levine 3,4 , Hanzhang Lu 1,5 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2 Biomedical Engineering, University of Texas Southwestern Medical Center/University of Texas at Arlington, TX, USA; 3 Institute for Exercise & Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA; 4 Internal Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 5 Biomedical Engineering , University of Texas Southwestern Medical Center/University of Texas at Arlington, TX, USA Perfusion MRI: DSC & DCE MRI Room 710B 10:30-12:30 Moderators: Geoffrey J. M. Parker & Matúš Straka 10:30 784. Separation of Intra- & Extra-Vascular Spaces in Human Brain with DCE-MRI & 11 C- Verapamil PET Xiaoping Zhu 1 , John R. Cain 1 , Shaonan Wang 1 , Maria Feldmann 1,2 , Gerry Thompson 1 , Ka-Loh Li 1 , Marie Claude Asselin 1 , Alan Jackson 1 1 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom; 2 Department of Clinical & Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom 10:42 785. Whole-Brain CBF Measurements using DCE-MRI & 3D k-t PCA Henrik Pedersen 1 , Adam E. Hansen 1 , Henrik B. W. Larsson 1 1 Functional Imaging Unit (KFNA), Glostrup Hospital, Glostrup, Denmark 10:54 786. Accurate Brain Tumor Blood Volume Estimation using DCE-MRI with Bookend T1 Measurements & Phase- Derived AIFs Greg O. Cron 1 , Claire Foottit 1 , Jean Francois Mercier 1 , Rebecca Thornhill 1 , Viviane Thanh-Van Nguyen 2 , Ian Cameron 1 , Mark E. Schweitzer 1 , J. J. Shankar 1 , John Sinclair 1 , John Woulfe 1 , Matthew J. Hogan 3 , Thanh B. Nguyen 1 1 2 3 The Ottawa Hospital, Ottawa, Ontario, Canada; University of Montreal; Neuroradiology, University of Ottawa, Ottawa, Ontario, Canada 11:06 787. Discriminant Analysis to Classify the Glioma Grading using DCE MRI & Immunohistochemical Markers Rishi Awasthi 1 , Prativa Sahoo 2 , Nuzhat Husain 3 , Priyanka Soni 3 , Ashish Awasthi 4 , Rohit Kumar Singh 5 , Sanjay Behari 5 , Chandra M. Pandey 4 , Ram Kishan Singh Rathore 6 , Rakesh Kumar Gupta 1 1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2 Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; 3 Pathology, Chatrapati Sahu ji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 4 Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 5 Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 6 Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India 107
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1 Radiology, CHOA, Atlanta, GA, Uni
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