Poster <strong>Session</strong>s 248 2267. MRI Reveals Differences in Neuroanatomy of Mouse Models of NPC Disease John Totenhagen 1 , Eriko Yoshimaru 1 , Ivan Borbon 2 , Christy Howison 3 , Robert Erickson 2 , Theodore Trouard 1 1 Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2 Pediatrics, University of Arizona, Tucson, AZ, United States; 3 Arizona Research Laboratories, University of Arizona, Tucson, AZ, United States 2268. Reduction of Contralateral White Matter Volume After Experimental Focal Epilepsy & Hemispherectomy in Rats Willem M. Otte 1,2 , Kajo van Der Marel 2 , Kees P. J. Braun 1 , Rick M. Dijkhuizen 2 1 Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands; 2 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands 2269. Long Term Observations on Status-Epilepticus Induced Neurodegeneration: A 7 Tesla MR Study in a Rat Model Martin Meier 1 , Jens P. Bankstahl 2 , Marion Bankstahl 2 , Xiao-Qi Ding 3 1 Small Animal Imaging Facility, Hannover Medical School, Hannover, Germany; 2 Institute for Pharmacology, Toxicology & Pharmacy, University of Veterinary Medicine, Hannover, Germany; 3 Institute of Diagnostic & Interventional Neuroradiology, Hannover Medical School, Hannover, Germany 2270. Metabolic & Morphological Characterization of the Mecp2-308 Truncated Mouse Model of Rett Syndrome: Effects of a Treatment Activating Rho GTPases Rossella Canese 1 , Bianca De Filippis 1 , Carla Fiorentini 2 , Alessia Fabbri 2 , Paola Porcari 1 , Laura Ricceri 1 , Giovanni Laviola 1 1 Cell Biology & Neurosciences Dept., Istituto Superiore di Sanità, Rome, RM, Italy; 2 Therapeutic Research & Medicine Evaluation Dept., Istituto Superiore di Sanità, Rome, RM, Italy 2271. Molecular Imaging of Inflammation in a Cerebrovascular Aneurysm Model. Alexei A. Bogdanov 1 , Matthew J. Gounis, Ronn Walvick, Ajay K. Wakhloo 1 Radiology, UMASS Medical School, Worcester, MA, United States 2272. Reduced Functional Connectivity in Normal Aging in Non-Human Primates Alexandre Coimbra 1 , Dai Feng 2 , Marie Holahan 1 , Jacquelynn Cook 1 , Donald Williams 1 , Richard Baumgartner 2 1 Imaging, Merck & Co, Inc, West Point, PA, United States; 2 Biometrics, Merck & Co, Inc, Rahway, NJ, United States 2273. Characterization of Lesions & Regional Brain Tissue of ArcAbeta Mice Based on Magnetic Susceptibility Andreas Deistung 1 , Jan Klohs 2 , Ferdinand Schweser 1 , Joanes Grandjean 2 , Marco Dominietto 2 , Conny Waschkies 2 , Roger M. Nitsch 3 , Markus Rudin 2,4 , Jürgen R. Reichenbach 5 1 Medical Physics Group, Department of Diagnostic & Interventional Radiology I, Jena University Hospital , Jena, Germany; 2 Institute for Biomedical Engineering, ETH & University of Zürich, Switzerland; 3 Division of Psychiatry Research, University of Zürich, Switzerland; 4 Institute of Pharmacology & Toxicology, University of Zürich , Switzerland; 5 Medical Physics Group, Department of Diagnostic & Interventional Radiology I, Jena University Hospital, Jena, Germany 2274. Voxel-Based Morphometry Reveals Localised Cerebral Atrophy in a Mouse Lemur Model of Aging Stephen John Sawiak 1,2 , Marc Dhenain 3 1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England, United Kingdom; 2 Behavioural & Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom; 3 MIRCen, I2BM Institute of Biomedical Imaging, Fontenay aux Roses, France 2275. Cortical Atrophy in Experimental Autoimmune Encephalomyelitis Allan J. MacKenzie-Graham 1 , Gilda A. Rinek 1 , Stefan M. Gold 2 , Andrew J. Frew 1 , Cynthia Aguilar 3 , David R. Lin 1 , Elizabeth Umeda 1 , Rhonda R. Voskuhl 1 , Jeffry R. Alger 1 1 University of California, Los Angeles, Los Angeles, CA, United States; 2 Universität Hamburg, Hamburg, Germany; 3 Indiana University of Pennsylvania, Indiana, PA, United States 2276. Voxel-Based Morphometry using DARTEL in the Mouse Reveals Differential Impact of Early & Late Prenatal Inflammation on Adult Brain. Charlton Cheung 1 , Qi Li 2,3 , Edward X. Wu 2,4 , Grainne Mary McAlonan 5,6 1 Psychiatry, University of Hong Kong, Pokfulam, Hong Kong; 2 University of Hong Kong, Hong Kong; 3 Centre for Reproduction, Development and Growth; 4 4Laboratory of Biomedical Imaging and Signal Processing; 5 University of Hong Kong, Hong Kong, Hong Kong; 6 State Key Laboratory for Brain and Cognitive Sciences 2277. Axonal Damage Caused by Exposure of Axon Terminals to Amyloid Beta David Carrick 1 , Bruce Campbell 2 , Hsiao-Fang Liang 3 , Wei-Xing Shi 4 , Shu-Wei Sun 5 1 Basic Science, School of Medicine, Loma Linda University, Loma Linda, CA, United States; 2 Clinical Laboratory Science, School of Allied Health, Loma Linda University, Loma Linda; 3 Biophysics & Bioengineering, Loma Linda University; 4 Pharmaceutical Sciences & Basic Sciences, Schools of Pharmacy & Medicine, Loma Linda University; 5 Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States
Poster <strong>Session</strong>s 2278. Longitudinal MRI Study to Monitor Brain Changes of RTg4510 Mice Related Tauopathy Suppressed With/without Doxycycline Dewen Yang 1 , Zhiyong Xie 1 , David Caouette 2 , Carol Hicks 2 , Anthony Millici 2 , David Raunig 3 1 2 3 BioImaging COE, Pfizer Worldwide Research & Development, Groton, CT, United States; Neuroscience RU; Neuroscience Research Statistics 2279. Does Decompression Sickness Lead to Brain Injuries? Marius Widerøe 1 , Marianne Havnes 2 , Andreas Møllerløkken 2 , Alf Brubakk 2 , Marte Thuen 2 1 Dep of Laboratory Medicine, Children's & Women's Health, Norwegian University of Science & Technology, Trondheim, Norway; 2 Dep of Circulation & Medical Imaging, Norwegian University of Science & Technology, Trondheim, Norway 2280. The Effect of the Ketogenic Diet on Neuroinflammation in an EAE Mouse Model of Multiple Sclerosis Gregory H. Turner 1 , Do-Young Kim 1 , Junwei Hao 1 , Ruolan Liu 1 , Jong M. Rho 1 , Fu-Dong Shi 1 1 Barrow Neurological Institute, Phoenix, AZ, United States 2281. In Vivo Pathological Mapping of the Rat Brain Infected with Angiostrongylus Cantonensis using MRI Ling-Yuh Shyu 1 , Hao-Hung Tsai 2,3 , Shin-Tai Chong 2 , Tzu-Hua Lee 2 , Kwong-Chung Tung 4 , Jun-Cheng Weng 2,3 1 Department of Parasitology, Chung Shan Medical University, Taichung, Taiwan; 2 School of Medical Imaging & Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan; 3 Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; 4 Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan 2282. MRI Studies of Neuroprotection in a Mouse Model of Radiation Necrosis Xiaoyu Jiang 1 , John A. Engelbach, Dinesh K. Thotala 2 , Robert E. Drzymala 2 , Dennis E. Hallahan 2 , Joel R. Garbow 3 , Joseph J. H. Ackerman 3 1 Department of Chemistry, Washington University in St. louis, St. louis, MO, United States; 2 Department of Radiation Oncology, Washington University School of Medicine; 3 Department of Radiology, Washington University School of Medicine 2283. Anatomical Phenotyping of the PML Knockout Mouse Benjamin Sinclair 1,2 , Jon Cleary 2 , Joanne Henderson 3 , Marc Modat 1 , Francesca Norris 2,4 , Paolo Salomoni 3 , Sebastien Ourselin 1 , Mark Lythgoe 2 1 Centre for Medical Image Computing, UCL, London, United Kingdom; 2 Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; 3 UCL Cancer Institute, London, United Kingdom; 4 Centre for Mathematics & Physics in the Life Sciences & EXperimental Biology (CoMPLEX) 2284. Early Metabolic Changes in the Amyotrophic Lateral Sclerosis SOD1 Mouse Brain Are Revealed using 1 H MRS Rather Than CASL & 18 FDG PET Hongxia Lei 1,2 , Elisabeth Dirren 3 , Carol Poitry-Yamate 1 , Bernard L. Schneider 3 , Patrick Aebischer 3 , Rolf Gruetter 1,4 1 Laboratory of Functional & Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Radiology, Univeristy of Lausanne, Lausanne, Switzerland; 3 Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 4 Radiology, University of Geneva, Geneva, Switzerland 2285. Rates of Change of 1 H & 31 P MRS Cerebral Metabolites Vs Lactate/NAA in the 48h Following Global Transient Global Hypoxia-Ischaemia in the Newborn Piglet Nicola Jayne Robertson 1 , Stuart Faulkner 1 , Alan Bainbridge 2 , Manigandan Chandrasekaran 1 , Dorottya Kelen 1 , Sudhin Thayyil 1 , Ernest Cady 2 , Xavier Golay 3 , Gennadij Raivich 1 1 Institute for Women's Health, University College London, London, United Kingdom; 2 Medical Physics & Bioengineering, University College Hospitals, London, United Kingdom; 3 UCL Institute of Neurology, London, United Kingdom 2286. Acute Hypoglycemia Induces Increased Brain Lactate Uptake & Metabolism in Rats. Henk M. De Feyter 1 , Kevin L. Behar 2 , Robin A. de Graaf, Douglas L. Rothman, 3 1 2 3 Diagnostic Radiology, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale University; Department of Biomedical Engineering, Yale University 2287. Multiparametric MR Assays of Spinocerebellar Ataxia 17 Transgenic Mice Chiao-Chi V. Chen 1,2 , Zhi-Xuan Kuo 1,2 , Hsiu-Mei Hsieh 3 , Chen Chang 1,2 1 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2 Functional & Micro-magnetic Resonance Imaging Center, Academic Sinica, Taipei, Taiwan; 3 Department of Life Science, National Taiwan Normal University, Taipei, Taiwan 2288. Longitudinal Study of Neurochemical Changes in Q140 Mouse Model of Huntington’s Disease Ivan Tkac 1 , Lori Zacharoff 2 , Janet M. Dubinsky 2 1 2 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; Department of Neuroscience, University of Minnesota 2289. Optimal Therapeutic Hypothermia Temperature Following Perinatal Asphyxia: A Magnetic Resonance Spectroscopy Biomarker & Immunohistochemistry Study in the Newborn Piglet. Nicola Jayne Robertson 1 , Stuart Faulkner 1 , Manigandan Chandrasekaran 1 , Alan Bainbridge 2 , David Price 2 , Dorottya Kelen 1 , Aron Kerenyi 1 , Sudhin Thayyil 1 , Elizabeth Powell 1 , Ernest Cady 2 , Gennadij Raivich 1 , Xavier Golay 3 249
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