Poster <strong>Session</strong>s 328 1 Clinical MRI Unit, Royal Marsden Hospital, Institute of Cancer Research & EPSRC Cancer Imaging Centre, Sutton, Surrey, United Kingdom; 2 Drug Development Unit, Royal Marsden Hospital & Institute of Cancer Research, Sutton, Surrey, United Kingdom 14:30 3123. Preliminary Result of Pharmacokinetic Parameter Evaluation in Malignant Pleural Mesothelioma: Correlation with Histology & Growth Type. Hatsuho Mamata 1,2 , Ritu R. Gill 1,2 , Junichi Tokuda 1,2 , Robert F. Padera 2,3 , Robert E. Lenkinski 2,4 , William G. Richards 2,5 , Tamara R. Tilleman 2,5 , David J. Sugarbaker 2,5 , Hiroto Hatabu 1,2 1 Radiology, Brigham & Women's Hospital, Boston, MA, United States; 2 Harvard Medical School, Boston, MA, United States; 3 Pathology, Brigham & Women's Hospital, Boston, MA, United States; 4 Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 5 Thoracic surgery, Brigham & Women's Hospital, Boston, MA, United States 15:00 3124. Comparison of Parameters of Dynamic Contrast Enhanced (DCE-)MRI & Contrast Enhanced UltraSound (CEUS) Applied in a Clinical Pharmacological Study Ulrike Fasol 1 , Annette Frost 2 , Martin Buechert 1 , Klaus Mross 2 , Jann Arends 2 1 MR Development & Application Center, University Medical Center Freiburg, Freiburg, Germany; 2 Tumor Biology Center, Albert- Ludwigs-University Freiburg, Freiburg, Germany Perfusion & Permeability: Preclinical & Clinical II Exhibition Hall <strong>Monday</strong> 14:00-16:00 Computer 15 14:00 3125. Dynamic Contrast Enhanced MRI of the Liver for Therapy Monitoring of Hepatic Metastases from Neuroendocrine Tumors Wieland H. Sommer 1 , Steven Sourbron 2 , Maximilian F. Reiser 1 , Karin A. Herrmann 1 , Christoph Zech 1 1 2 Department of Radiology, University Hospital Munich, Grosshadern Campus, Munich, Bavaria, Germany; University of Leeds, Leeds, United Kingdom 14:30 3126. Correlation of Intravoxel Incoherent Motion with Dynamic Contrast Enhanced MRI Derived Parameters in Neck Nodal Metastases Yonggang Lu 1 , Jacobus F. A. Jansen 2 , Hilda E. Stambuk 1 , Yousef Tehrani-Mazaheri 1 , Nancy Lee 1 , Jason A. Koutcher 1 , Amita Shukla-Dave 1 1 2 Memorial Sloan-Kettering Cancer Center, New York, NY, United States; Maastricht University Medical Center, Maastricht,, Netherlands 15:00 3127. Combined MRI Texture & Shape Analysis for the Prediction of Biologic Aggressiveness in Musculoskeletal Neoplasms Rebecca E. Thornhill 1 , Greg O. Cron 1 , Ian Cameron 1 , Adnan Sheikh 1 , Gina Di Primio 1 , Joel Werier 1 , Mark E. Schweitzer 1 , Jing Zhang 2 , Xiao Guang Cheng 2 1 The Ottawa Hospital, Ottawa, Ontario, Canada; 2 Beijing Ji Shui Tan Hospital, Beijing, China, People's Republic of 15:30 3128. Dynamic Contrast-Enhanced Magnetic Resonance Imaging & Dynamic Contrast-Enhanced Computed Tomography of Primary Colorectal Cancer: Comparison of Test-Retest Agreement. N. Jane Taylor 1 , Ian C. Simcock 1 , J. James Stirling 1 , Aftab Khan 2 , Rob Glynne-Jones 2 , Anwar R. Padhani 1 , Vicky J. Goh 1 1 Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom; 2 Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom Tumor Therapy Response - Preclinical & Clinical Exhibition Hall Tuesday 13:30-15:30 Computer 16 14:00 3129. DCE-MRI in Rat Gliomas Under Therapy with Temozolomide & a Nitric Oxide Donor Claudia Weidensteiner 1 , Mehdi Ordikhani-Seyedlar 2 , Anna Werres 3 , Nadja Osterberg 3 , Astrid Weyerbrock 3 , Wilfried Reichardt 2 1 MR Development & Application Center, University Medical Center Freiburg, Freiburg, Germany; 2 Department of Radiology/Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 3 Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany 14:30 3130. Multiparametric Imaging for Therapy Response to Cytotoxic & Cytostatic Agents in Xenograft Mice Natalie J. Serkova 1 , Erica L. Pierce 2 , Kendra M. Hasebroock 1 , Andrea L. Merz 1 , Todd M. Pitts 2 , Gail Eckhardt 2 1 Anesthesiology, University of Colorado Denver, Aurora, CO, United States; 2 Medical Oncology, University of Colorado Denver 15:00 3131. Assessment of Early Tumor Response to Chemotherapy using MR Elastography (MRE) Jun Chen 1 , Kiaran P. McGee 1 , Yogesh K Mariappan 1 , Kevin J. Glaser 1 , Stephen M. Ansell 1 , Kay M. Pelletier 1 , Deanna M. Grote 1 , Richard L. Ehman 1
1 Mayo Clinic, Rochester, MN, United States Poster <strong>Session</strong>s 15:30 3132. Comparisons of the Efficacy of the Jak1/2 Inhibitor AZD1480 with the VEGF Signaling Inhibitor Cediranib (AZD2171) & Sham Treatments in Mouse Tumors using DCE-MRI, DW-MRI, & Histology Mary E. Loveless 1,2 , Deborah Lawson 3 , Michael Collins 3 , Deborah Morosini 3 , Corinne Reimer 3 , Dennis Huszar 3 , Jane Halliday 4 , John C. Waterton 4 , John C. Gore 2,5 , Thomas E. Yankeelov 2,5 1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 2 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3 Cancer Bioscience, AstraZeneca, Boston, MA, United States; 4 Translational Sciences: Imaging, AstraZeneca, Macclesfield, Cheshire, United Kingdom; 5 Radiology & Radiological Science, Vanderbilt University, Nashville, TN, United States Exhibition Hall Tuesday 13:30-15:30 Computer 16 13:30 3133. Treatment Response Assessment of a Novel Vascular-Disrupting Agent on Rabbit Tumor Model using DCE- MRI Kyung Won Kim 1 , Jeong Min Lee 1 , Ji Suk Park 1 , Yong Sik Jeon 1 , Joon Koo Han 1 , Byung Ihn Choi 1 1 Radiology, Seoul National University Hospital, Seoul, Korea, Republic of 14:00 3134. Textural Analysis of DCE-MRI of the Breast as a Predictor of Response Peter Gibbs 1 , Arfan Ahmed 1 , Martin Pickles 1 , Lindsay Turnbull 1 1 Centre for MR Investigations, University of Hull, Hull, United Kingdom 14:30 3135. Monitoring Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer by 3D Proton Magnetic Resonance Spectroscopy Imaging Bogumil-Krystian Debski 1 , Wolfgang Bogner 1 , Marek Chmelik 1 , Katja Pinker, Thomas Helbich, Siegfried Trattnig 1 , Stephan Gruber 1 1 MR Centre of Excellence, Dept. Radiology, Medical University of Vienna, Vienna, Austria 15:00 3136. Evaluation of the Role of DW-MRI in the Assessment of Tumor Response to Sunitinib in Metastatic Renal Cell Carcinoma. Nishat Bharwani 1 , Marc E. Miquel 2 , Thomas Powles 3 , Redha Boubertakh 2 , Anju Sahdev 1 , Rodney H. Reznek 1 , Andrea G. Rockall 1 1 Radiology, Barts & the London NHS Trust, London, United Kingdom; 2 Medical Physics, Barts & the London NHS Trust, London, United Kingdom; 3 Medical Oncology, Barts & the London NHS Trust, London, United Kingdom Exhibition Hall Wednesday 13:30-15:30 Computer 16 13:30 3137. Sunitinib Induces Reductions in Tumor Vascular Permeability & Intra-Tumor Vascular Volume in Renal Cell Carcinoma Mark Alan Rosen 1 , Yiqun Xue 1 , Sarah Englander 1 , Daniel Heitjian 2 , Hyunseon S. Kang 1 , Anna Fagan 1 , Naomi Haas 3 , William Lee 3 , William Carley 4 , Hee Kwon Song 1 , Stephen Keefe 3 , Yu Jiangsheng 1 1 Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States; 3 Medicine, University of Pennsylvania, Philadelphia, PA, United States; 4 Pfizer, Inc., Collegeville, PA, United States 14:00 3138. The δK trans DCE-MRI Parameter Provides Early Prediction of Soft-Tissue Sarcoma Therapy Response: Initial Experience Stephanie Hemmingson 1 , Kelly Perlewitz 2 , Megan Holtorf 2 , Ian Tagge 1 , William Woodward 1 , Christopher Ryan 2 , Charles Springer 1 , Wei Huang 1 1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2 Medicine, Oregon Health & Science University, Portland, OR, United States 14:30 3139. DCE-MRI as a Prognostic Factor in Osteosarcoma Junyu Guo 1 , John O. Glass 1 , Qing Ji 1 , Catherine A. Billups 2 , Najat C. Daw 3 , Wilburn E. Reddick 1 1 Translational Imaging Research, Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, United States; 2 3 Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; Division of Pediatrics, MD Anderson Cancer Center, Houston, TX, United States 15:00 3140. MRI Analysis of Bone Metastasis: Shape-Related Exclusion Criteria Rafal M Kedzierski 1 , Paul T. Weatherall 2 1 2 Radiology, John Peter Smith Hospital, Fort Worth, TX, United States; Radiology, Univ. of Texas Southwestern Medical Center, Dallas, TX, United States 329
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