Poster <strong>Session</strong>s 178 1505. Hyperpolarized [1- 13 C]-Lactate as a Tool for the In Vivo Investigation of Cardiac Metabolism Dirk Mayer 1,2 , Yi-Fen Yen 3 , Ralph Hurd 3 , Sonal Josan 1,2 , Jae Mo Park 2 , Adolf Pfefferbaum 1,4 , Daniel Spielman 2 1 Neuroscience Program, SRI International, Menlo Park, CA, United States; 2 Radiology, Stanford University, Stanford, CA, United States; 3 GE Healthcare; 4 Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, United States 1506. Design & Performance of a Multi-Sample Dissolution Dynamic Nuclear Polarization Setup Michael Batel 1 , Marcin Krajewski 2 , Kilian Weiss 2 , Oliver With 1 , Alexander Däpp 1 , Andreas Hunkeler 1 , Martin Gimersky 3 , Matthias Ernst 1 , Sebastian Kozerke 2 1 Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland; 2 Institute for Biomedical Engineering, University & ETH Zürich, Zürich, Switzerland; 3 Laboratory for Electromagnetic Fields and Microwave Electronics, ETH Zürich, Zürich, Switzerland 1507. Multi-Band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1- 13 C]Pyruvate Cornelius von Morze 1 , Galen Reed 1 , Peter J. Shin 1 , Peder E. Larson 1 , Robert Bok 1 , Simon Hu 1 , Daniel B. Vigneron 1 1 Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States 1508. The Spin-Lattice Relaxation of Hyperpolarized 89 Y Complexes Ashish K. Jindal 1 , Lloyd Lumata 1 , Yixun Xing 2 , Matthew E. Merritt 1 , Piyu Zhao 2 , Craig R. Malloy 1 , A. Dean Sherry 1,2 , Zoltan Kovacs 1 1 2 Advanced Imaging, UT Southwestern Medical Center, Dallas, TX, United States; Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States 1509. Novel Contrast Mechanism Via ParaHydrogen SElf Rfocussing Jan Falk Dechent 1,2 , Lisandro Buljubasich 2 , Laura Maria Scheiber 1 , Hans Wolfgang Spiess 2 , Kerstin Münnemann 2 1 2 Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany; Max Planck Institute for Polymer Research, Mainz, Germany 1510. The Effect of Hyperpolarized [1- 13 C]Pyruvate Concentration on Metabolism in the Perfused Heart Daniel Ball 1 , Marie Schroeder 1 , George Radda 1 , Kieran Clarke 1 , Damian Tyler 1 1 Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, United Kingdom 1511. In Vivo Measurement of Normal Rat Intracellular Pyruvate & Lactate Levels After Injection of Hyperpolarized [1- 13 C]Alanine Simon Hu 1 , Hikari Yoshihara 1 , Robert Bok 1 , Peder E. Larson 1 , John Kurhanewicz 1 , Daniel B. Vigneron 1 1 Dept. of Radiology & Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States 1512. Effect of Lanthanide Ions on Dynamic Nuclear Polarization Enhancement & Liquid State T 1 Relaxation Jeremy Gordon 1 , Ian Rowland 1,2 , Eric Peterson 3 , Sean Fain 1,2 1 Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3 Department of Biomedical Engineering, University of Wisconsin- Madison, Madison, WI, United States 1513. Probing the Relaxation Mechanism that Interferes with Polarization Measurement using the C 2 Doublet of 1,2- [ 13 C] 2-Pyruvate Justin Yat Cheong Lau 1,2 , Albert P. Chen 3 , Jianfeng Zhu 4 , Gang Wu 4 , Charles H. Cunningham 1,2 1 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 3 GE Healthcare, Toronto, Ontario, Canada; 4 Department of Chemistry, Queen's University, Kingston, Ontario, Canada 1514. The Influence of Bovine Serum Albumin on the T 1 Relaxation of [1- 13 C]Pyruvate – a Study at Low Fields Benjamin M. Pullinger 1 , Stephen J. Kadlecek 1 , Nicholas N. Kuzma 1 , Rahim R. Rizi 1 1 Radiology, University of Pennsylvania, Philadelphia, PA, United States 1515. Optimisation of Murine Cardiac Hyperpolarized Magnetic Resonance Spectroscopy using Dynamic Nuclear Polarization Michael Samuel Dodd 1 , Beat Schuler 1 , Vicky Ball 1 , Daniel Ball 1 , George K. Radda 1 , Houman Ashrafian 2 , Hugh Watkins 2 , Kieran Clarke 1 , Damian J Tyler 1 1 2 Physiology, Anatomy & Genetics, Oxford University, Oxford, United Kingdom; Cardiovascular Medicine, Oxford University, Oxford, United Kingdom 1516. Hepatic Hyperpolarized 13 C Pyruvate Studies: Origin of Additional In Vivo Pyruvate Resonances Eric T. Peterson 1 , Jeremy W. Gordon 2 , Sean B. Fain 2 , Ian J. Rowland 2 1 Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; 2 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States 1517. Retaining Polarization by Exploiting Reduced T 1 Relaxation of Hyperpolarized Spins at Low Field in Solution Mark Van Criekinge 1 , Kayvan R. Keshari, Daniel Vigneron, John Kurhanewicz 1 UCSF, San Francisco, CA, United States
Poster <strong>Session</strong>s 1518. Determination of Optimal Model Sampling Parameters for Hyperpolarized Contrast Agents Eric T. Peterson 1 , Matthew R. Smith 2 , Joseph J. Grudzinski 2 , Jeremy W. Gordon 2 , Sean B. Fain 1,2 1 Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; 2 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States 1519. Generation of Hyperpolarised Materials for Magnetic Resonance using High-Field Cryogenics David G. Gadian 1 , Kuldeep S. Panesar 2 , Angel J. Perez Linde 3 , Waldemar Senczenko 3 , Anthony J. Horsewill 2 , Walter Kockenberger 3 , John R. Owers-Bradley 2 1 Imaging & Biophysics Unit, UCL Institute of Child Health, London, United Kingdom; 2 School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom; 3 Sir Peter <strong>Mansfield</strong> MR Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom 1520. Surface Coils for Cardiac Imaging using Hyperpolarized 13 C at 3T William Dominguez-Viqueira 1 , Angus Z. Lau 1,2 , Albert P. Chen 3 , Charles H. Cunningham 2,4 1 Imaging Research , Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 3 GE Healthcare, Toronto, Ontario, Canada; 4 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada 1521. First Step to 19 F Hyperpolarization of Biocompatible Substrates Generated Via Parahydrogen-Transfer Ute Bommerich 1 , Thomas Trantzschel 2 , Joachim Bargon 3 , Gerd Buntkowsky 4 , Johannes Bernarding 2 1 2 SLNIB, Leibniz Institute for Neurobiology, Magdeburg, Germany; IBMI, University of Magdeburg, Magdeburg, Germany; 3 4 Institute of Physical Chemistry, University of Bonn, Bonn; Eduard-Zintl-Institute for Inorganic & Physical Chemistry, Technical University Darmstadt 1522. Advanced Parallel Imaging Techniques for Metabolic Imaging with Hyperpolarised 13 C Rolf F. Schulte 1 , Jonathan I. Sperl 1 , Axel Haase 2 , Marco Irkens 3 , Michael Manglberger 3 , Eliane Weidl 4 , Guido Kudielka 1 , Markus Schwaiger 4 , Florian Wiesinger 1 1 GE Global Research, Munich, Germany; 2 IMETUM, Technische Universitaet Muenchen, Munich, Germany; 3 Rapid Biomedical, Würzburg, Germany; 4 Department for Nuclear Medicine, Technische Universitaet Muenchen, Munich, Germany Perfusion & Permeability Methodology Exhibition Hall Tuesday 13:30-15:30 1523. Classification of Two-Site Exchange Models for DCE-MRI Steven Sourbron 1 , David L. Buckley 1 1 Division of Medical Physics, University of Leeds, Leeds, United Kingdom 1524. Effect of T 1 & Flip Angle Errors on Hepatic Arterial Fraction Calculation Daniel Wilson 1 1 Medical Physics, Leeds Teaching Hospitals, Leeds, West Yorkshire, United Kingdom 1525. Quantification of Blood-Brain Barrier Permeability in the Mouse Brain In Vivo: A Longitudinal Study Jieun Kim 1 , Nancy Berman 2 , Phil Lee 1 1 Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2 Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States 1526. Utility of Cardiac Gating for Pulmonary Perfusion MRI Kang Wang 1 , Mark Schiebler 2 , Christopher Francois 2 , Alejandro Munoz Del Rio 1,2 , Frank Korosec 1 , Sean Fain 1 , Scott Nagle 2 1 2 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; Radiology, University of Wisconsin-Madison, Madison, WI, United States 1527. In Vitro Skin Penetration Measurement with Contrast-Enhanced MRI at 7 Tesla Maximilian N. Voelker 1 , Jan M. Burg 2 , Peggy Schlupp 3 , Ulf Maeder, Alexander M. Koenig 1 , Johannes T. Heverhagen 1 1 Diagnostic Radiology, Philipps University Marburg, Marburg, Hessen, Germany; 2 Institute of Medical Physics & Radiation Protection, University of Applied Sciences Giessen-Friedberg, Giessen, Germany; 3 Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen-Friedberg, Giessen, Germany 1528. Series Expansion of Multi-Compartment Models for DCE-MRI Steven Sourbron 1 1 Division of Medical Physics, University of Leeds, Leeds, United Kingdom 179
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