Poster <strong>Session</strong>s 126 958. MRI-Guided Electrochemotherapy (ECT) in a Rat Model of Hepatocellular Carcinoma Yang Guo 1 , Yue Zhang 2,3 , Ning Jin 2,4 , Jodi Nicolai 2 , Rachel Klein 2 , Guang-Yu Yang 5 , Reed Omary 2,4 , Andrew Larson 2,4 1 Radiology, Northwestern University, Chicago, IL, United States; 2 Department of Radiology, Northwestern University, Chicago, IL, United States; 3 Biomedical Engineering , University of Illinois at Chicago, Chicago, IL, United States; 4 Department of Biomedical Engineering , Northwestern University, Chicago, IL, United States; 5 Department of Pathology, Northwestern University, Chicago, IL, United States 959. Characterizing Breast Tumor Lipid Metabolism by Integrating Magnetic Resonance Spectroscopic Imaging with MALDI Mass Spectrometric Imaging Lu Jiang 1 , Kamila Chughtai 2 , Dmitri Artemov 1 , Paul Winnard Jr. 1 , Venu Raman 1 , Zaver Bhujwalla 1 , Ron Heeren 2 , Kristine Glunde 1 1 ICMIC, Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical School, Baltimore, MD, United States; 2 FOM-Institute for Atomic & Molecular Physics, Amsterdam, Netherlands 960. Trifluoromisonidazole Detects Hypoxia - An In Vivo & In Vitro Multimodality Study Ellen Ackerstaff 1 , Makiko Suehiro 1 , Natalia Kruchevsky 1 , Sean Carlin 1 , Eric H. Rosenfeld 1 , Paul Burgman 1 , Guangbin Yang 1 , Geralda Torchon 1 , Ouathek Ouerfelli 1 , Pat B. Zanzonico 1 , Kristen L. Zakian 1 , Clifton C. Ling 1 , Jason A. Koutcher 1 1 Memorial Sloan-Kettering Cancer Center, New York, NY, United States 961. Chronic Administration of MRSI Agent IEPA Increases Tumor PH; Has Potential to Bias PH Measurement Heather H. Cornnell 1 , Ihor Luhach 1 , Gary Martinez 1 , Arig Ibrahim Hashim 1 , Robert A. Gatenby 2 , Robert J. Gillies 1 1 Department of Imaging, Moffitt Cancer Center & Research Instutite, Tampa, FL, United States; 2 Department of Radiology, Moffitt Cancer Center & Research Instutite, Tampa, FL, United States 962. Assessment of Tumour Glucose Uptake using Gluco-CEST Simon Walker-Samuel 1 , Peter Johnson 2 , Barbara Pedley 2 , Mark F. Lythgoe* 1 , Xavier Golay* 3 1 UCL Centre for Advanced Biomedical Imaging, Department of Medicine & Institute of Child Health, University College London, London, United Kingdom; 2 Institute of Cancer, University College London, United Kingdom; 3 Institute of Neurology, University College London, United Kingdom 963. Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models Lu Jiang 1 , Dmitri Artemov 1 , Paul Winnard Jr. 1 , Venu Raman 1 , Zaver Bhujwalla 1 , Kristine Glunde 1 1 ICMIC, Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical School, Baltimore, MD, United States 964. Metabolic Characterization of the Cachectic Phenotype Marie-France Penet 1 , Paul T. Winnard Jr. 1 , Radharani Marik 1 , Sridhar Nimmagadda 1 , Martin G. Pomper 1 , Zaver M. Bhujwalla 1 1 JHU ICMIC Program, Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States 965. In Vivo Magnetic Resonance Studies of Glycine Metabolism & Glutathione Distribution in a Rat Mammary Tumour Peter Edward Thelwall 1 , Nicholas E. Simpson 2 , Zahid N. Rabbani 3 , Daniel Clark 2 , Roxana Pourdeyhimi 4 , Jeffrey M. Macdonald 4 , Stephen J. Blackband 2 , Michael P. Gamcsik 4 1 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne & Wear, United Kingdom; 2 University of Florida, United States; 3 Duke University Medical Centre, United States; 4 University of North Carolina / NC State University, United States 966. Characterization of Macromolecular Transport in Hypoxic Tumor Environments with Disrupted Collagen I Fibers Samata M. Kakkad 1 , Marie-France Penet 1 , Arvind Pathak 1 , Meiyappan Solaiyappan 1 , Venu Raman 1 , Kristine Glunde 1 , Zaver M. Bhujwalla 1 1 JHU ICMIC Program, Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States 967. Arterial Spin Labeling Perfusion Measurements Reflect Histologic Microvessel Density in an Experimental Model of Tumor Response & Eventual Resistance to Antiangiogenic Therapy Xiaoen Wang 1 , Liang Zhang 2 , Michael P. Collins 3 , Brittany Bahamon 3 , Sabina Signoretti 3 , Michael B. Atkins 2 , David C. Alsop 4 , Rupal S. Bhatt 2 1 Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, United States; 2 Division of Hematology-Oncology & Cancer Biology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 3 Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, United States; 4 Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
Poster <strong>Session</strong>s 968. Evaluation of MR Imaging Biomarkers of the Infiltrative & Vascular Phenotype in Orthotopic Murine RG2 Gliomas Jessica K. R. Boult 1 , Lara Perryman 2 , Gary Box 3 , Chris Jones 2 , Suzanne A. Eccles 3 , Simon P. Robinson 1 1 Cancer Research UK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom; 2 Paediatric Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 3 Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, United Kingdom 969. A Dynamic Contrast-Enhanced MRI Comparison of the Perfusion of Spontaneous & Transplanted Pancreatic Ductal Adenocarcinoma in Genetically Engineered Mice Leanne Bell 1 , Davina Honess 2 , Dominick McIntyre 2 , David Tuveson 2 1 CRUK Cambridge Research Institute, Cambridge, United Kingdom; 2 CRUK Cambridge Research Institute, United Kingdom 970. Distribution of DCE-MRI Pharmacokinetic Parameter Maps in Early Murine Mammary Cancer Xiaobing Fan 1 , Sanaz A. Jansen 2 , Erica J. Markiewicz 1 , Gillian M. Newstead 1 , Gregory S. Karczmar 1 1 2 Radiology, The University of Chicago, Chicago, IL, United States; Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, United States 971. Development of a Spin Echo Gradient Echo Sequence for Simultaneous Assessment of the Biomarkers Vessel Size Index, Relative Blood Volume & Perfusion Stefan Zwick 1 , Wilfried Reichardt 1 , Claudia Weidensteiner 1 , Dominik von Elverfeldt 1 1 Dept. of Radiology, Medical Physics, University Medical Center, Freiburg, Germany 972. Evaluation of Gd-DTPA Contrast Enhancement of Lung & Metastatic Tumor with Ultra-Short Echo-Time Imaging Daisuke Kokuryo 1 , Ichio Aoki 1 , Tsuneo Saga 1 1 Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan 973. DCE-MRI of Genetic Mouse Model of Lung Cancer Kai Henrik Barck 1 , Anthony Lima 2 , Tim Cao 1 , Rafael Molina 2 , William F. Forrest 3 , Weilan Ye 4 , Leisa Johnson 2 , Richard A. D. Carano 1 1 Biomedical Imaging, Genentech, South San Francisco, CA, United States; 2 Molecular Biology, Genentech, South San Francisco, CA, United States; 3 Biostatistics, Genentech, South San Francisco, CA, United States; 4 Tumor Biology & Angiogenesis, Genentech, South San Francisco, CA, United States 974. Therapeutic Targeting of NG 2 Proteoglycan with MAb & Pre-Armed NK Cells in Human GBM Evaluated with Dynamic Enhanced & Diffusion Weighted MRI in Rats Marte Thuen 1 , Jien Wang 2 , Per Øyvind Enger 2 , Aurelie Poli 3,4 , Guro Løkka 2 , Else Marie Huuse 1 , Frits Thorsen 2 , Cecilie Brekke Rygh 2 , Martha Chekenya 2 1 Dep of Circulation & Medical Imaging, Norwegian University of Science & Technology, Trondheim, Norway; 2 Department of Biomedicine, University of Bergen, Bergen, Norway; 3 Translational Cancer Research, University of Bergen, Norway; 4 Lab for Immunology & Allergology, CRP sante, Luxembourg, Luxembourg 975. Timing of Anti-Angiogenic Therapy in Brain Tumors using MRI Measures of Relative Cerebral Blood Volume & Apparent Diffusion Coefficient Kimberly R. Pechman 1,2 , Deborah L. Donohoe 2,3 , Devyani Bedekar 2,3 , Kathleen M. Schmainda 2,4 1 Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Translational Brain Tumor Research Program, Medical College of Wisconsin, Milwaukee, WI, United States; 3 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 4 Radiology & Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States 976. Optimization of Combined Bevacizumab Plus Temozolomide Therapy in Brain Tumor Xenograft Models using MRI Measures of Relative Cerebral Blood Volume Kimberly R. Pechman 1,2 , Deborah L. Donohoe 2,3 , Devyani P. Bedekar 2,3 , Kathleen M. Schmaind 2,4 1 Neurosurgery, Medical College of Wisconsin, Millwaukee, WI, United States; 2 Translational Brain Tumor Research Program, Medical College of Wisconsin, Milwaukee, WI, United States; 3 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 4 Radiology & Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States 977. MR Visualization of Depot Vaccines & Immune Activation for Cancer Therapies Drew R. DeBay 1 , Sarah A. LeBlanc 1 , Genevieve M. Weir 2 , Marc Mansour 2 , Chris V. Bowen 1,3 1 National Research Council - Institute for Biodiagnostics (Atlantic), Halifax, Nova Scotia, Canada; 2 Immunovaccine Inc., Halifax, Nova Scotia, Canada; 3 Department of Physics & Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada 978. DMSO-Based Contrast as a Potential Intermediate Endpoint Biomarker of GBM Response to Therapy. Teresa Delgado-Goñi 1,2 , Juana Martin-Sitjar 1,2 , Rui V. Simões 1,2 , Milena Acosta 1,2 , Silvia Lope-Piedrafita 2,3 , Carles Arús 1,2 127
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