Wednesday PM 17:00 443. Measuring Whole Kidney Nephron Endowment using MRI Scott Charles Beeman 1 , Min Zhang 2 , Lina Gubhaju 3 , David Frakes 1,2 , John Bertram 3 , Teresa Wu 2 , Kevin Bennett 1 1 School of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ, USA; 2 School of Electrical, Computer & Energy Engineering, Arizona State University, Tempe, AZ, USA; 3 Department of Anatomy & Developmental Biology, Monash University, Melbourne, Victoria, Australia 17:12 444. Follow-up of Living Kidney Donors After Transplantation by DWI reveals Compensatory Changes in the Remaining Kidney. Peter Vermathen 1 , Tobias Binser 1 , Harriet C. Thoeny 2 , Chris Boesch 1 , Felix J. Frey 3 , Ute Eisenberger 3 1 Dept. of Clinical Research, University of Bern, Bern, Switzerland; 2 Dept. of Radiology, University & Inselspital, Bern, Switzerland; 3 Dept. of Nephrology, University & Inselspital, Bern, Switzerland 17:24 445. Measurement of Single-Kidney Glomerular Filtration Rate (GFR) by Arterial Spin Labeling Xiang He 1 , Kyongtae Ty Bae 1 1 Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA 17:36 446. Diffusion Tensor Imaging (DTI) & Tractography for Assessment of Renal Allograft Dysfunction Katja Hueper 1 , Marcel Gutberlet 1 , Dagmar Hartung 1 , Frank Lehner 2 , Wilfried Gwinner 3 , Xiaoqi Ding 4 , Michael Galanski 1 Radiology, Hannover Medical School, Hannover, Germany; 2 General, Abdominal & Transplant Surgery, Hannover Medical School; 3 Nephrology, Hannover Medical School; 4 Neuroradiology, Hannover Medical School 17:48 447. Renal Perfusion Measured Pre- & Post-Transplantation with ASL MRI in Donor-Recipient Pairs Nathan S. Artz 1 , Elizabeth A. Sadowski 2 , David J. Niles 1 , Karl K. Vigen 1 , Andrew L. Wentland 1 , Arjang Djamali 3 , Thomas M. Grist 1,2 , Sean B. Fain 1,2 1 Medical Physics, University of Wisconsin, Madison, WI, USA; 2 Radiology, University of Wisconsin, Madison, WI, USA; 3 Nephrology, University of Wisconsin, Madison, WI, USA Targeted Molecular Imaging Room 511D-F 16:00-18:00 Moderators: Peter Caravan & Angelique Louie 16:00 448. Theranostic Imaging of Metastatic Prostate Cancer Zhihang Chen 1 , Marie-France Penet 1 , Sridhar Nimmagadda 1 , Cong Li 1 , Sangeeta Ray 1 , Paul T. Winnard Jr. 1 , Dmitri Artemov 1 , Kristine Glunde 1 , Martin G. Pomper 1 , Zaver M. Bhujwalla 1 1 JHU ICMIC Program, Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA 16:12 449. Positive Contrast for Imaging of Receptor Targeted Magnetic Nanoparticles in the Orthotopic Pancreatic Cancer Xenograft Model using Ultrashort Echo Time MRI Liya Wang 1,2 , Xiaodong Zhong 3 , Weiping Qian 4 , Hongwei Chen 1,2 , Lily Yang 4 , Hui Mao 1,2 1 Radiology, Emory University School of Medicine, Atlanta, GA, USA; 2 Center for Systems Imaging, Emory University, Atlanta, GA, USA; 3 MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, USA; 4 Surgery, Emory University School of Medicine, Atlanta, GA, USA 16:24 450. MR Imaging Guided NCT by a Dual Gd/B Agent Targeted to Tumor Cells via Upregulated LDL Transporters. Simonetta Geninatti-Crich 1 , Diego Alberti 1 , Ibolya Szabo 1 , Antonio Toppino 2 , Annamaria Deagostino 2 , Paolo Venturello 2 , Nicoletta Protti 3 , Silva Bortolussi 3 , Saverio Altieri 3 , Silvio Aime 1 1 University of Torino, Torino, Italy; 2 University of Torino, Italy; 3 University of Pavia, Italy 16:36 451. Multimodal Molecular Imaging of Angiogenesis in a Mouse Model of Melanoma Giselle Alexandra Suero Abreu 1 , Benjamin B. Bartelle 1 , Orlando Aristizábal 1 , Edward J. Houston 2 , Daniel H. Turnbull 2,3 1 Skirbal Institute of Biomolecular Medicine, NYU School of Medicine, New York, USA; 2 Skirbal Institute of Biomolecular Medicine, NYU School of Medicine, New York, USA; 3 Radiology Department, NYU School of Medicine, New York, NY, USA 16:48 452. Direct Protein Imaging of Inflammation in the Human Hand Jamu K. Alford 1 , A. Gregory Sorensen 1 , Thomas Benner 1 , Blaine A. Chronik 2 , William Bradfield Handler 2 , Timothy J. Scholl 3 , Gunjan Madan 4 , Peter Caravan 1 1 Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2 Physics & Astronomy, The University of Western Ontario, London, ON, Canada; 3 Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada; 4 Siemens Medical Solutions Inc., Malvern, PA, USA 64
Wednesday PM 17:00 453. Molecular MRI of Liver Fibrosis by Fibrin-Fibronectin Targeted Contrast Agent in an Experimental Mouse Model April M. Chow 1,2 , Mingqian Tan 3 , Darwin S. Gao 1,4 , Shu Juan Fan 1,4 , Jerry S. Cheung 1,4 , Kwan Man 5 , Zheng-Rong Lu 3 , Ed X. Wu 1,4 1 Laboratory of Biomedical Imaging & Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China, People's Republic of; 2 Medical Physics & Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China, People's Republic of; 3 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 4 Department of Electrical & Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China, People's Republic of; 5 Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong SAR, China, People's Republic of 17:12 454. In Vivo Dynamic Contrast Enhanced MRI of Novel Contrast Agents Targeted to the Estrogen Receptor Adi Pais 1 , Gunanathan Chidambaram 2 , Inbal Biton 3 , Raanan Margalit 1 , David Milstein 2 , Hadassa Degani 1 1 Biological Regulation, Weizmann Institute of Science, Rehovot, Israel; 2 Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel; 3 Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel 17:24 455. MRI with Magnetic Nanoparticles Serves As a Biomarker For the Inflammation Associated with the Early, Insulitic Phase of Type I Diabetes Alexander R. Guimaraes 1,2 , Jason L. Gaglia 3,4 , Mukesh G. Harisinghani 2 , Christophe Benoist 3,4 , Diane Mathis 3,4 , Ralph Weissleder 1 1 Center for Systems Biology, Boston, MA, USA; 2 Radiology/Massachusetts General Hospital, Division of Abdominal Imaging & Interventional Radiology, Boston, MA, USA; 3 Pathology, Harvard Medical School, Boston, MA, USA; 4 Section on Immunology & Immunogenetics, Joslin Diabetes Center, Boston, MA, USA 17:36 456. MRI of Cells & Mice At 1 & 7Tesla with Gd-Targeting Agents: When the Low Field is Better! Simonetta Geninatti-Crich 1 , Diego Alberti 1 , Ibolya Szabo 1 , Dario Longo 1 , Silvio Aime 1 1 University of Torino, Torino, Italy 17:48 457. Enhanced Relaxivity of Hydroxyapatite-Targeted Gadolinium Contrast Agents Jonathan Marmurek 1,2 , Khaled Nasr 3 , Elena Vinogradov 2 , Ananth J. Madhuranthakam 4 , John V. Frangioni 3 , Robert E. Lenkinski 2 1 Harvard-MIT Division of Health Sciences & Technology, Cambridge, MA, USA; 2 Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 3 Hematology & Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 4 Global Applied Science Laboratory, GE Healthcare, Boston, MA, USA Stroke - Clinical Studies Room 512A-G 16:00-18:00 Moderators: Jeffry R. Alger & Charlotte Rosso 16:00 458. Ischemic Penumbra in Acute MCA Stroke: Comparison of the PWI-DWI Mismatch & the ADC-Based NEURINFARCT Methods Aurelie Drier 1,2 , Thomas Tourdias 3 , Igor Sibon 4 , Yohan Attal 5 , Gurkan Mutlu 6 , Stéphane Lehéricy 1,2 , Yves Samson 6 , Jacques Chiras 1 , Didier Dormont 1 , Jean-Marc Orgogozo 4 , Vincent Dousset 3 , Charlotte Rosso 6 1 Neuroradiology, Pitié Salpêtrière Hospital, Paris, France; 2 Centre de NeuroImagerie de Recherche - CENIR,CRICM U795, Paris, France; 3 Neuroradiology, CHU Pellegrin, Bordeaux, France; 4 Neurology, CHU Pellegrin, Bordeaux, France; 5 CRICM, CNRS, UMR7225 équipe NEMESIS, Paris, France; 6 Urgences cérébro-vasculaires, Pitié Salpêtrière Hospital, Paris, France 16:12 459. Bolus Delay & Dispersion in Predictor Models in Acute Stroke Lisa Willats 1 , Alan Connelly 1,2 , Soren Christensen 3,4 , Geoffrey Donnan 2,5 , Stephen Davis 4,6 , Fernando Calamante 1,2 1 Brain Research Institute, Florey Neuroscience Institutes , Melbourne, Australia; 2 Department of Medicine, University of Melbourne, Australia; 3 Department of Radiology, University of Melbourne, Australia; 4 Royal Melbourne Hospital, Melbourne, Australia; 5 Florey Neuroscience Institutes, Melbourne, Australia; 6 Department of Neurology, University of Melbourne, Australia 16:24 460. Comparison of Pseudo-Continuous Arterial Spin-Labeled & Dynamic Susceptibility Contrast Enhanced Perfusion Imaging in Acute Ischemic Stroke Danny J. J. Wang 1 , David S. Liebeskind 1 , Qing Hao 1 , Joe X. Qiao 2 , Rana Fiazv 1 , Matthias Gunther 3,4 , Whitney B. Pope 2 , Samuel Hou 2 , Lirong Yan 1 , Jeffrey L. Saver 1 , Noriko Salamon 2 , Jeffry R. Alger 1,2 1 Neurology, UCLA, Los Angeles, CA, USA; 2 Radiology, UCLA, Los Angeles, CA, USA; 3 Faculty of Physics & Electronics, University of Bremen, Bremen, Germany; 4 Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen, Germany 16:36 461. Reversal of Abnormal ADC Lags Reperfusion & Does Not Necessarily Represent Tissue Salvage Hongyu An 1 , Andria L. Ford 2 , Katie D. Vo 3 , William J. Powers 4 , Jin-Moo Lee 2 , Weili Lin 1 1 Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 2 Neurology, Washington University in St. Louis, St. Louis, MO, USA; 3 Radiology, Washington University in St. Louis, St. Louis, MO, USA; 4 Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 65
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