Poster <strong>Session</strong>s 238 2169. Similar Cortical Lesion Distribution & Cortical Atrophy Location in Patients with Relapsing-Remitting Multiple Sclerosis. Marco Battaglini 1 , Massimiliano Calabrese 2 , Maria Laura Stromillo 1 , Alice Favaretto 2 , Antonio Giorgio 1 , Francesca Rinaldi 2 , Paolo Gallo 2 , Nicola De Stefano 1 1 2 Neurological & Behavioral Sciences, University of Siena, Siena, Toscany, Italy; Multiple Sclerosis Center of Veneto Region, University of Padua, Padova 2170. Effect of Multiple Sclerosis Lesions on the MTR of Grey & White Matter in the Cervical Spinal Cord Hugh Kearney 1 , Marios C. Yiannakas 1 , Rebecca Samson 1 , Claudia A. M. Wheeler-Kingshott 1 , Olga Ciccarelli 1,2 , David H. Miller 1 1 Department of Neuroinflammation, UCL institute of Neurology, London, United Kingdom; 2 Department of Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom 2171. Periventricular Venous Density in MS Patients Correlates with T2 Lesion Load - a 7 Tesla MRI Study Paul Mittelstaedt 1 , Tim Sinnecker 1 , Jan Markus Doerr 1 , Caspar F. Pfueller 1 , Lutz Harms 1 , Thoralf Niendorf 2,3 , Friedemann Paul 1,4 , Jens Wuerfel 2,5 1 Charité University Medicine, Berlin, Germany; 2 Max-Delbrueck-Center for Molecular Medicin, Berlin, Germany; 3 Berlin Ultrahigh Field Facility, Berlin, Germany; 4 NeuroCure Clinical Research Center , Berlin, Germany; 5 University of Luebeck, Luebeck, Schleswig-Holstein, Germany 2172. Diffusion Tensor Parameters of the Optic Radiations Are Associated with Visual Acuity & Retinal Nerve Fiber Layer Loss Following Optic Neuritis Robert a Bermel 1 , Salim E. Abboud 1 , Blessy Mathew 2 , Ken E. Sakaie 2 , Stephen E. Jones 2 , Michael D. Phillips 2 , Mark J. Lowe 2 1 2 Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; Imaging Institute, Cleveland Clinic, Cleveland, OH, United States 2173. Changes in Diffusion Tensor Eigenvalues in Corpus Callosum in Secondary Progressive Multiple Sclerosis: A Longitudinal DTI Study Wei Tian 1 , Tong Zhu 1 , Jianhui Zhong 1 , Xiang Liu 1 , Praveen Rao 2 , Benjamin M. Segal 2 , Xiang Liu 1 Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States; 2 University of Michigan 2174. Short-Term Stability of T 1 & T 2 Relaxation Measures in Multiple Sclerosis Normal Appearing White Matter Alice Liang 1 , Irene M. Vavasour 2 , Anthony L. Traboulsee 3 , Joel Oger 3 , Donna J. Lang 2 , David K. B. Li 2 , Alex L. MacKay 1,2 , Cornelia Laule 2,4 1 Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada; 2 Radiology, University of British Columbia, Vancouver, BC, Canada; 3 Medicine, University of British Columbia, Vancouver, BC, Canada; 4 Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada 2175. Estimation of Total Myelin Volume in the Brain J. B. M. Warntjes 1,2 , J. West 1,3 , O. Dahlqvist-Leinhard 1,3 , G. Helms 4 , A.-M. Landtblom 5 , P. Lundberg 6,7 1 Linköping University, Center for Medical Image Science & Visualization, Linköping, Sweden; 2 Department of Medicine & Health, division of clinical physiology, Linköping, Sweden; 3 Department of Medicine & Health, Division of Radiation Physics, Linköping, Sweden; 4 University Medical Center, MR-Research in Neurology & Psychiatry, Göttingen, Germany; 5 Department of Clinical Neuroscience, Linköping, Sweden; 6 Linköping University, Dept of Radiation Physics & Dept of Radiology, IMH, University of Linkoping, Linköping, Sweden; 7 University Hospital of Linköping, Dept of Radiation Physics & Dept of Radiology, CKOC, University Hospital of Linkoping, Linköping, Sweden 2176. Quantitative Evaluation of Spinal Cord Tissue Damage in MS Patients using Gradient Echo Plural Contrast Imaging Jie Luo 1 , Anne H. Cross 2 , Dmitriy A. Yablonskiy 3 1 Chemistry, Washington University in St. Louis, St.Louis, MO, United States; 2 Neurology, Washington University School of Medicine, St. Louis, MO, United States; 3 Radiology, Washington University School of Medicine, St. Louis, MO, United States White Matter Diseases Exhibition Hall Tuesday 13:30-15:30 2177. Automatic Segmentation of White Matter Hyperintensities Based on Reaction Diffusion with Adaptive Threshold Shuangxi Ji 1 , Yining Huang 2 , Jing Fang 1,3 , Jue Zhang 1,3 1 College of Engineering, Peking University, BEIJING, China, People's Republic of; 2 Dept.of Neurology, Peking University, BEIJING, China, People's Republic of; 3 Academy for Advanced Interdisciplinary Studies, Peking University, BEIJING, China, People's Republic of
Poster <strong>Session</strong>s 2178. Neuromyelitis Optica: Are Cortical Lesions a Common Finding? Benjamin Bender 1 , Lena Zeltner 2 , Felix Bischof 2 , Uwe Klose 1 1 Department of Diagnostic & Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Baden-Württemberg, Germany; 2 Department of Neurology, University Hospital Tübingen, Tübingen, Baden-Württemberg, Germany Structural & Functional MRI in Parkinson Disease Exhibition Hall Wednesday 13:30-15:30 2179. 7T MRI Reveals an Inhomogeneous Cortex & Changes in Gray-White Matter Phase in Alzheimer's Disease Sanneke van Rooden 1 , Maarten J. Versluis 1 , Julien R. Milles 2 , Andrew G. Webb 1 , Mark A. van Buchem 1 , J. van Der Grond 1 1 C.J. Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands; 2 LKEB, Department of Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands 2180. 3-D Surface Analysis of the Substantia Nigra in Parkinson's Disease Obtained with 7T MRI Dae-Hyuk Kwon 1 , Jong-Min Kim 2 , Se-Hong Oh 1 , Hye-Jin Jeong 1 , Sung-Yeon Park 1 , Je-Geun Chi 1,3 , Young-Bo Kim 1 , Beom-Seok Jeon 2 , Zang-Hee Cho 1 1 Neuroscience Research Institute, Gachon University of Medicine & Science, Kuwol-dong Namdong-gu, Incheon, Korea, Republic of; 2 3 Departments of Neurology, Seoul National University, Seoul, Korea, Republic of; Departments of Pathology, Seoul National University, Seoul, Korea, Republic of 2181. Direct Visualization of Parkinson's Disease by In Vivo Human Brain Imaging using 7.0T MRI Se-Hong Oh 1 , Jong-Min Kim 2 , Sung-Yeon Park 1 , Dae-Hyuk Kwon 1 , Hye-Jin Jeong 1 , Myung-Kyun Woo 1 , Young-Bo Kim 1 , John Huston III 3 , Kendall H. Lee 4 , Beom S. Jeon 2 , Zang-Hee Cho 1 1 Neuroscience Research Institute, Gachon University of Medicine & Science, Incheon, Korea, Republic of; 2 Departments of Neurology, College of Medicine, Seoul National University, Seoul, Korea, Republic of; 3 Department of Radiology, Mayo Clinic, Rochester, United States; 4 4Department of Neurosurgery & Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, United States 2182. Quantitative Analysis of the Substantia Nigra in Parkinson's Disease Implementing 3D Modeling at 7.0T MRI Hye-Jin Jeong 1 , Se-Hong Oh 1 , Jong-Min Kim 2 , Dae-Hyuk Kwon 1 , Sung-Yeon Park 1 , Joshua H. Park 1 , Young-Bo Kim 1 , Je-Geun Chi 1,3 , Chan-Woong Park 1 , Beom S. Jeon 2 , Zang-Hee Cho 1 1 Neuroscience Research Institute, Gachon University of Medicine & Science, Incheon, Korea, Republic of; 2 Department of Neurology ,College of Medicine, Seoul National University, Seoul, Korea, Republic of; 3 Departments of Pathology,College of Medicine, Seoul National University, Seoul, Korea, Republic of 2183. Improved Sensitivity & Specificity in the Diagnosis of Parkinson's Disease from Diffusion Kurtosis Imaging JiunJie Wang 1 , WeyYil Lin 2 , ChinSung Lu 3 , Ali Tabesh 4 , YiHsin Weng, YauYau Wai 1 ChangGung University, TaoYuan county, Taiwan, Taiwan; 2 ChangGung Memorial Hospital, TaoYuan county, Taiwan, Taiwan; 3 ChangGung Memorial Hospital; 4 NewYork University Medical School 2184. Grey Matter Loss is Associated with Freezing-Of-Gait in Parkinson’s Disease Federica Agosta 1 , Vladimir S. Kostic 2 , Michela Pievani 1 , Milica Jecmenica-Lukic 2 , Elka Stefanova 2 , Antonio Scarale 1 , Massimo Filippi 1 1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute & University Hospital San Raffaele, Milan, Italy; 2 Department of Neurology, University of Belgrade School of Medicine, Belgrade, Yugoslavia 2185. Detection & Quantification of Alpha- Synuclein using Fast Field- Cycling Magnetic Resonance Techniques Saadiya Rashid Ismail 1,2 , Sarah Mustafa 2 , Samantha Miller 2 , Tim Rasmussen 2 , David J. Lurie 1 , Peter Teismann 2 1 2 ABIC, University of Aberdeen, Aberdeen, Aberdeenshire, United Kingdom; IMS, University of Aberdeen, Aberdeen, Aberdeenshire, United Kingdom 2186. Neurochemical Profiling of Two Rodent Parkinson’s Disease Models: An In Vivo MR Spectroscopy Study Mélanie Craveiro 1 , Philippe Coune 2 , Bernard Schneider 2 , Patrick Aebischer 2 , Rolf Gruetter 1,3 1 Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Neurodegenerative Studies Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 3 Universities of Lausanne & Geneva, Departments of Radiology, Switzerland 2187. Perfusion Deficits Predate Grey Matter Atrophy in Cognitively-Impaired Parkinson’s Disease Tracy Robert Melzer 1,2 , Richard Watts 1,3 , Michael R. MacAskill 1,2 , Ross J. Keenan 4 , Ajit Shankaranarayanan 5 , David C. Alsop 6 , Leslie Livingston 1,2 , John C. Dalrymple-Alford 1,7 , Tim J. Anderson 1,2 1 Van der Veer Institute for Parkinson's & Brain Research, Christchurch, New Zealand; 2 Medicine, University of Otago, Christchurch, New Zealand; 3 Physics & Astronomy, University of Canterbury, Christchurch, New Zealand; 4 Christchurch Radiology Group, 239
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