Poster <strong>Session</strong>s 368 3 Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, United Kingdom; 4 Department of Radiology, Addenbrooke’s Hospital, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom 15:00 3514. Chemical Shift Selective Imaging of Hyperpolarized 13 C using Variable Phase Balanced Steady-State Free Precession Aaron Keith Grant 1 , Elena Vinogradov 1 , Xiaoen Wang 1 , Hao Wang 1 , Pankaj K. Seth 2 , Vikas P. Sukhatme 2 , David C. Alsop 1 , Robert E. Lenkinski 1 1 Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States; 2 Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States 15:30 3515. Super Stimulated-Echo Preparation for Hyperpolarized 13 C Metabolic Imaging Peder Eric Zufall Larson 1 , Adam B. Kerr 2 , Ralph E. Hurd 3 , John Kurhanewicz 1 , John M. Pauly 2 , Daniel B. Vigneron 1 1 Radiology & Biomedical Imaging, UC - San Francisco, San Francisco, CA, United States; 2 Electrical Engineering, Stanford University, Stanford, CA, United States; 3 Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States Exhibition Hall Tuesday 13:30-15:30 Computer 49 13:30 3516. Transient Decrease in Tumor PO 2 by 13 C-Pyruvate Injection Keita Saito 1 , Shingo Matsumoto 1 , Nallathamby Devasahayam 1 , Sankaran Subramanian 1 , Jeeva P. Munasinghe 2 , Jan Henrik Ardenkjaer-Larsen 3 , Herman Douglas Morris 2 , Martin J. Lizak 2 , James B. Mitchell 1 , Murali C. Krishna 1 1 National Cancer Institute, Bethesda, MD, United States; 2 National Institute of Neurological Disorder & Stroke; 3 GE Healthcare 14:00 3517. Metabolic Kinetics of a Glioma Model using Hyperpolarized 13 C Magnetic Resonance Spectroscopic Imaging Jae Mo Park 1,2 , Sonal Josan 2,3 , Taichang Jang 4 , Milton Merchant 4 , Yi-Fen Yen 5 , Ralph Hurd 5 , Lawrence Recht 4 , Daniel Spielman 1,2 , Dirk Mayer 2,3 1 Department of Electrical Engineering, Stanford University, Stanford, CA, United States; 2 Department of Radiology, Stanford University, Stanford, CA, United States; 3 SRI International, Menlo Park, CA, United States; 4 Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States; 5 Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States 14:30 3518. Construction & Use of a Cryostat for Hyperpolarization Based on a 15 Cm, 4.6T Magnet Lloyd Lumata 1 , Richard Martin 1 , Ashish Jindal 2 , Zoltan Kovacs 1 , Craig Malloy 1 , A. Dean Sherry 1 , Mark Conradi 3 , Matthew E. Merritt 1 1 2 3 AIRC, UTSW Medical Center, Dallas, TX, United States; UTSW Medical Center, United States; Physics, Washington University in St. Louis, St. Louis, MO, United States 15:00 3519. Fast Volumetric Imaging of Ethanol Metabolism in Rat with Hyperpolarized [1- 13 C]-Pyruvate Sonal Josan 1,2 , Daniel Spielman 2 , Yi-Fen Yen 3 , Ralph Hurd 3 , Adolf Pfefferbaum 1,4 , Dirk Mayer 1,2 1 SRI International, Menlo Park, CA, United States; 2 Radiology, Stanford University, Stanford, CA, United States; 3 GE Healthcare Applied Science Laboratory, Menlo Park, CA, United States; 4 Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States Exhibition Hall Wednesday 13:30-15:30 Computer 49 13:30 3520. Simultaneous Bloch-Siegert B 1 Mapping & Imaging of Hyperpolarized Pyruvate, Bicarbonate, & Lactate, in a Single Tracer Bolus Angus Zoen Lau 1,2 , Albert P. Chen 3 , Charles H. Cunningham 1,2 1 Medical Biophysics, University of Toronto, Toronto, ON, Canada; 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3 GE Healthcare, Toronto, ON, Canada 14:00 3521. Investigating the Role of PDH Inhibition on the Development of Hypertrophy in the Hyperthyroid Rat Heart Helen J. Atherton 1,2 , Michael S. Dodd 1 , Lisa C. Heather 1 , Marie A. Schroeder 1 , Julian L. Griffin 2 , George K. Radda 1 , Kieran Clarke 1 , Damian J. Tyler 1 1 Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; 2 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom 14:30 3522. Method for Robust PH Measurement using Hyperpolarized Bicarbonate & Carbon Dioxide Albert P. Chen 1 , Ralph E. Hurd 2 , Marie A. Schroeder 3,4 , Angus Z. Lau 4,5 , Yi-Ping Gu 4 , Wilfred W. Lam 4 , Charles H. Cunningham 4,5 1 GE Healthcare, Toronto, ON, Canada; 2 GE Healthcare, Menlo Park, CA, United States; 3 Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; 4 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 5 Deptartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada 15:00 3523. Spectroscopic Imaging of Cerebral Metabolism using Hyperpolarized [1- 13 C]Pyruvate & Multi-Echo Single- Shot RARE Sequence
Poster <strong>Session</strong>s Peter Otto Magnusson 1 , Sadia Asghar Butt 1 , Mette Hauge Lauritzen 1 , Jan Henrik Ardenkjær-Larsen 2 , Per Åkesson 1 , Lise Vejby Søgaard 1 1 2 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; GE Healthcare, Hillerød, Denmark Exhibition Hall Thursday 13:30-15:30 Computer 49 13:30 3524. Autophagy Induced by DCA Treatment, PI3K Inhibition or Starvation Results in Reduced Pyruvate to Lactate Exchange Observed by DNP 13 C-MRS. Yuen-Li Chung 1 , Gigin Lin 1 , Helen Troy 1 , Anne-Christine Wong Te Fong 1 , L. E. Jackson 1 , Deborah K. Hill 1 , Matthew Orton 1 , Dow-Mu Koh 1 , Simon P. Robinson 1 , Ian R. Judson 2 , John R. Griffiths 3 , Martin O. Leach 1 , Thomas R. Eykyn 1 1 CR-UK & EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2 CR-UK Centre for Cancer Therapeutics, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 3 Li Ka Shing Centre, CR-UK Cambridge Research Institute, Cambridge, United Kingdom 14:00 3525. Investigating Tumor Perfusion & Metabolism using Multiple Hyperpolarized 13 C Compounds: HP001, Urea, & Pyruvate Cornelius von Morze 1 , Peder E. Larson 1 , Simon Hu 1 , Robert Bok 1 , Hikari Yoshihara 1 , Andrei Goga 2 , Jan Henrik Ardenkjaer-Larsen 3 , Daniel B. Vigneron 1 1 Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States; 2 Department of Medicine, Division of Hematology / Oncology, UCSF, San Francisco, CA, United States; 3 GE Healthcare, Hillerød, Denmark 14:30 3526. Arterial Input Function by DNP Measurement using an Automated Injector Designed for a 7T Unshielded Magnet Steven Reynolds 1 , Samira Kazan 2 , Leigh Williams 2 , Aneurin Kennerley 3 , Jason Berwick 3 , Gillian Tozer 2 , Martyn Paley 1 1 Academic unit of Radiology, Medical School, University of Sheffield, Sheffield, S. Yorkshire, United Kingdom; 2 Department of Oncology, Medical School, University of Sheffield, Sheffield, S. Yorkshire, United Kingdom; 3 Department of Psychology, University of Sheffield, Sheffield, S. Yorkshire, United Kingdom 15:00 3527. Efficient Preparation of Hyperpolarized Aqueous Succinate from the Para-Hydrogenation & Hydrolysis of Maleic Anhydride Francesca Reineri 1 , Alessandra Viale 1 , Silvano Ellena 1 , Tommaso Boi 1 , Roberto Gobetto 1 , Silvio Aime 1 1 University of Torino, Torino, IT, Italy Hyperpolarized 13 C II Exhibition Hall <strong>Monday</strong> 14:00-16:00 Computer 50 14:00 3528. Effects of RF Excitation Scheme on Signal-To-Noise-Ratio & Apparent Rate Constant Estimation in Dynamic Volumetric Imaging of Hyperpolarized [1- 13 C]-Pyruvate Sonal Josan 1,2 , Ralph Hurd 3 , Adam B. Kerr 4 , Yi-Fen Yen 3 , Peder E. Z. Larson 5 , Adolf Pfefferbaum 1,6 , Daniel Spielman 2 , Dirk Mayer 1,2 1 SRI International, Menlo Park, CA, United States; 2 Radiology, Stanford University, Stanford, CA, United States; 3 GE Healthcare Applied Science Laboratory, Menlo Park, CA, United States; 4 Electrical Engineering, Stanford University, Stanford, CA, United States; 5 Dept of Radiology & Biomedical Imaging, UC-San Francisco, San Francisco, CA, United States; 6 Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, United States 14:30 3529. Dynamic Imaging of Hyperpolarized [2- 13 C] Pyruvate & [5- 13 C] Glutamate in the Heart Angus Zoen Lau 1,2 , Albert P. Chen 3 , Marie A. Schroeder 4 , Jennifer Barry 2 , Charles H. Cunningham 1,2 1 Medical Biophysics, University of Toronto, Toronto, ON, Canada; 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3 GE Healthcare, Toronto, ON, Canada; 4 Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom 15:00 3530. Localized In Vivo Hyperpolarization Transfer Experiments Mor Mishkovsky 1,2 , Tian Cheng 1 , Rolf Gruetter 1,3 , Arnaud Comment 1,2 1 Laboratory for Functional & Metabolic Imaging , Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Department of Radiology, Université de Lausanne, Lausanne, Switzerland; 3 Department of Radiology, Universités de Lausanne et de Genève, Lausanne & Genève, Switzerland 15:30 3531. Single-Shot, Frequency & Time Specific, 3D Imaging Method for Measuring Hyperpolarized 13 C Biomarkers In-Vivo at 14.1 Tesla Subramaniam Sukumar 1 , Kayvan R. Keshari 1 , Robert Bok 1 , Vickie Zhang 1 , Andrew Taylor 1 , Michael A. Ohliger 1 , Hikari Yoshihara 1 , John Kurhanewicz 1 , Daniel B. Vigneron 1 1 Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States 369
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