Poster <strong>Session</strong>s 236 2148. Early Metabolic Biomarkers Identifying Permanent Stroke in Mouse Brain using 1 H MRS Hongxia Lei 1,2 , Carole Berthet 3 , Lorenz Hirt 3 , Rolf Gruetter 1,4 1 Laboratory of Functional & Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Radiology, Univeristy of Lausanne, Switzerland; 3 Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Switzerland; 4 Radiology, University of Geneva, Geneva, Switzerland 2149. Early Post-Ischemic Neuroprotective Mechanisms: A MR Spectroscopic Imaging Study on PPARβ-Deficient Mice Mélanie Craveiro 1 , Laure Quignodon 2 , Carole Berthet 3 , Matthew Hall 2 , Cristina Cudalbu 1 , Lorenz Hirt 3 , Béatrice Desvergne 2 , Rolf Gruetter 1,4 1 Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 3 Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 4 Departments of Radiology, Universities of Lausanne & Geneva, Switzerland 2150. Ischemic Brain Damage & Loss of Ion Homeostasis During Focal Ischemia Fernando Emilio Boada 1 , Edwin Nemoto 2 , Yongxian Qian 3 , Costin Tanase 3 , Charles Jungreis 4 , Jonathan Weimer, Vincent Lee 1 Radiology & Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; 2 Neurosurgery, University of New Mexico, Albuquerque, NM, United States; 3 Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 4 Radiology, Temple University, Philadelphia, PA, United States 2151. The Effect of Amyloid on Infarct Size in a Rat Model Simona Nikolova 1 , Zareen Amtul 2 , David Cechetto 2 , Ting-Yim Lee 3 , Vladimir Hachinski 4 , Robert Bartha 2,3 1 Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada; 2 Department of Anatomy, University of Western Ontario, London, ON, Canada; 3 Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada; 4 London Health Sciences Centre, London, ON, Canada 2152. The Importance of Reperfusion Injury in Antenatal Hypoxia-Ischemia: Novel Fetal MRI Diagnostic Parameters & Novel Antioxidant Therapy Alexander Drobyshevsky 1 , Xinhai Ji 1 , Matthew Derrick 1 , Lei Yu 1 , Ines Batinic-Haberle 2 , Sidhartha Tan 1 1 2 Pediatrics, Evanston Northshore Healthcare, Evanston, IL, United States; Radiation Oncology, Duke University Medical Center, Durham, NC, United States 2153. MRI Evaluation of Carotid Morphology & Function in a Rabbit Constriction Model of Atherosclerosis: A Feasibility Study Steve J. Sawiak 1 , Valentina Taviani 2 , Victoria E. Young 2 , Joe L. Bird 3 , Hugh K. Richards 4 , Andrew J. Patterson 2 , Martin J. Graves 2 , Adrian T. Carpenter 1 , Jonathan H. Gillard 2 1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2 Department of Radiology, University of Cambridge, Cambridge, United Kingdom; 3 Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom; 4 Department of Anesthesia, University of Cambridge, Cambridge, United Kingdom 2154. T 2*-Weighted Signal Change of Oxygen Challenge as a Potential Better Penumbra Estimation—A Transient Occlusion Study Fang Du 1 , Qiang Shen 1,2 , Shiliang Huang 1 , Timothy Q. Duong 1,2 1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2 Ophthalmology/Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 2155. Incorporating ADC Temporal Profiles in Acute Stroke to Predict Ischemic Tissue Fate Qiang Shen 1,2 , Virendra Desai 1 , Timothy Q. Duong 1,2 1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2 Ophthalmology/Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 2156. In Vivo Kurtosis Imaging in Murine Cerebral Ischemia Andreas Lemke 1 , Saskia Grudzenski 2 , Jörg Döpfert 1 , Frederik Bernd Laun 3 , Tristan Kuder 3 , Marc Fatar 2 , Lothar Rudi Schad 1 1 Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2 Experimental Neurology, Heidelberg University, Mannheim, Germany; 3 Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany Multiple Sclerosis Exhibition Hall <strong>Monday</strong> 14:00-16:00 2157. Baseline T 2 MRI Texture Predicts Visual Recovery in Patients with Acute Optic Neuritis Yunyan Zhang 1 , Fiona Costello 1 , James N. Scott, Luanne M. Metz 1
1 University of Calgary, Calgary, AB, Canada Poster <strong>Session</strong>s 2158. White Matter Attenuation Sequence Optimization at 7T with Applications in Multiple Sclerosis & Epilepsy Katharine Teal Bluestein 1 , Peter Wassenaar 1 , Petra Schmalbrock 1 , Michael V. Knopp 1 1 Wright Center of Innovation, Department of Radiology, The Ohio State University, Columbus, OH, United States 2159. Relationship between MR Phase & Tissue Microstructure Saba El-Hilo 1 , Stella Atkins, Alexander Rauscher 2 1 Simon Fraser University, Vancouver, BC, Canada; 2 UBC MRI Research Centre 2160. Diffusion Tensor MR Spectroscopy to Assess Microstructural Changes in Patients with Multiple Sclerosis Wafaa Zaaraoui 1 , Yann Le Fur 1 , Alexandre Vignaud 2 , Elisabeth Soulier 1 , Patrick Viout 1 , Irina Malikova 1,3 , Audrey Rico 1,3 , Bertrand Audoin 1,3 , Sylviane Confort-Gouny 1 , Patrick J. Cozzone 1 , Jean Pelletier 1,3 , Jean-Philippe Ranjeva 1 1 CRMBM UMR CNRS 6612, Marseille, France, Metropolitan; 2 Siemens Healthcare, Saint-Denis, France, Metropolitan; 3 Pôle de Neurosciences Cliniques, Service de Neurologie, Hôpital de La Timone, Marseille, France, Metropolitan 2161. Pathobiochemistry of Brain Damage in Multiple Sclerosis: Changes in Choline & Creatine Compounds Measured by 1 H and 31 P MRSI Elke Hattingen 1 , Ulf Ziemann 2 , Jörg Magerkurth 1 , Mathias Wahl 2 , Ulrich Pilatus 1 1 2 Institute of Neuroradiology, Goethe University Frankfurt/Main, Frankfurt, Germany; Klinik für Neurologie, Goethe University Frankfurt/Main, Frankfurt, Germany 2162. Automatic Segmentation of Gray Matter Multiple Sclerosis Lesions on FLAIR & DIR Images Elisa Veronese 1 , Enrico Grisan 1 , Massimiliano Calabrese 2 , Alice Favaretto 2 , Paolo Gallo 2 , Dario Seppi 2 , Filippo Rinaldi 2 , Irene Mattisi 2 , Alessandra Bertoldo 1 1 Department of Information Engineering, University of Padova, Padova, Italy; 2 University Hospital of Padova 2163. Statistical Model for Predicting MS Cortical Lesion Detection Rates Based on Lesion Size & MRI Contrast & Resolution Cherian Renil Zachariah 1 , David Pitt 2 , Katharine Teal Bluestein 1 , Bradley Clymer 3 , Michael Knopp 1 , Petra Schmalbrock 1 1 Wright Center of Innovation, Radiology Department, The Ohio State University, Columbus, OH, United States; 2 Neurology Department, The Ohio Sate University, Columbus, OH, United States; 3 Department of Electrical & Computer Engineering, The Ohio State University, Columbus, OH, United States 2164. Characterization of Functional Homotopy in Multiple Sclerosis using Resting-State Functional MRI Lin Tang 1 , Xinian Zuo 2,3 , Clare Kelly 2,3 , Yongxia Zhou 1 , Hina Jaggi 1 , Joseph Herbert 1 , Robert I. Grossman 1 , Michael Milham 2,3 , Yulin Ge 1 1 Radiology, Center for Biomedical Imaging of New York University, New York, NY, United States; 2 Phyllis Green & Randolph Cowen Institute for Pediatric Neuroscience; 3 New York University Child Study Center, New York, NY, United States 2165. Is Every Multiple Sclerosis Lesion a “black Hole”? Comparison of T 1-Weighted MRI at 1.5T & 7.0T Tim Sinnecker 1 , Paul Mittelstaedt 1 , Jan Markus Doerr 1 , Caspar F. Pfueller 1 , Lutz Harms 1 , Thoralf Niendorf 2,3 , Friedemann Paul 1,4 , Jens Wuerfel 2,5 1 Charité University Medicine, Berlin, Germany; 2 Max-Delbrueck-Center for Molecular Medicin, Berlin, Germany; 3 Berlin Ultrahigh Field Facility, Berlin, Germany; 4 NeuroCure Clinical Research Center , Berlin, Germany; 5 University Luebeck, Berlin, Germany 2166. Susceptibility Contrast in Deep Brain Gray Matter Areas in Multiple Sclerosis Studied with 7T MRI Bing Yao 1 , Francesca Bagnato 2 , Karin Shmueli 1 , Jeff H. Duyn 1 1 Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States; 2 Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, MD, United States 2167. Contrast Assessment of Synthetic Magnetic Resonance Imaging in Clinical Practice I. Blystad 1,2 , J. B. M. Warntjes 2,3 , T. Helmersson 2 , P. Lundberg 4,5 1 Department of Medical & Health Sciences, Radiology, Linköping, Sweden; 2 Center for Medical Image Science & Visualization, Linköping, Sweden; 3 Division of Clinical Physiology, Linköping, Sweden; 4 Dept of Radiation Physics & Dept of Radiology, IMH, University of Linkoping, Linköping, Sweden; 5 Dept of Radiation Physics & Dept of Radiology, CKOC, University Hospital of Linkoping, Linköping, Sweden 2168. R 2’ is Reduced in Normal Appearing White Matter & Lesions & Increased in the Basal Ganglia in Patients with Multiple Sclerosis David J. Paling 1 , Daniel J. Tozer 1 , Claudia A. M. Wheeler-Kingshott 1 , Xavier Golay 1 , Raju Kapoor 1 , David H. Miller 1 1 Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom 237
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