Friday <strong>AM</strong> 17:36 659. Metabolic Imaging of the Rat Brain using Hyperpolarized [1- 13 C]Ketoisocaproate & [1- 13 C]Pyruvate Sadia Asghar Butt 1 , Lise Vejby Søgaard 1 , Peter Magnusson 1 , Mette Lauritzen 1 , Per Åkeson 1 , Jan Henrik Ardenkjær- Larsen 2 1 Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark; 2 GE Healthcare, Broendby, Denmark 17:48 660. In Vivo Detection of Brain Krebs Cycle Intermediate By Hyperpolarized MR Mor Mishkovsky 1,2 , Arnaud Comment 1,2 , Rolf Gruetter 1,3 1 Laboratory for Functional & Metabolic Imaging , Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 Department of Radiology, Université de Lausanne, Lausanne, Switzerland; 3 Department of Radiology, Universités de Lausanne et de Genève, Lausanne & Genève, Switzerland Cell Tracking & Gene Expression Room 520B-F 16:00-18:00 Moderators: Eric T. Ahrens & Piotr Walczak 16:00 661. CEST MRI for Monitoring Bacteriolytic Tumor Therapy Guanshu Liu 1,2 , Chetan Bettegowda 3 , Assaf A. Gilad 4,5 , Michael T. McMahon 1,2 , Kannie W. Y. Chan 2,5 , Kenneth W. Kinzler 3 , Bert Vogelstein 3 , Jeff W. M. Bulte 2,5 , Shibin Zhou 3 , Peter C. M. van Zijl 1,2 1 F. M. Kirby center, Kennedy Krieger Institute, Baltimore, MD, USA; 2 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3 Ludwig Center, Howard Hughes Medical Institute & Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 4 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5 Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA 16:12 662. Magnetization Transfer Contrast MRI Detects Pseudomonas Aeruginosa Bacterial Infection Bacterial Infection a Mouse Burn Model Valeria Righi 1,2 , Melissa Starkey 3 , Laurence G. Rahme 3 , Ronald G. Tompkins 4 , Aria A. Tzika 1,2 1 Department of Surgery, NMR Surgical Laboratory, MGH & Shriners Burn Institute, Harvard Medical School, Boston, MA, USA; 2 Department of Radiology, Athinoula A. Martinos Center of Biomedical Imaging, Boston, MA, USA; 3 Department of Surgery, Molecular Surgery Laboratory, MGH & Shriners Burn Institute, Harvard Medical School, Boston, MA, USA; 4 Department of Surgery, MGH & Shriners Burn Institute, Harvard Medical School, Boston, MA, USA 16:24 663. High-Efficiency Targeting of Glial Precursor Cells to Inflammatory Brain Lesions using the VLA4-VC<strong>AM</strong>1 Cell Adhesion Pathway: Real-Time MR Monitoring of Instant Cell Engraftment Inema Orukari 1,2 , Mike Gorelik 3 , Joann Wang 3 , Shashikala Galpoththawela 1 , Heechul Kim 1 , Douglas A. Kerr 4 , Michael Levy 5 , Andre Levchenko 3 , Jeff Bulte 1 , Piotr Walczak 1 1 Russell H. Morgan Department of Radiology & Radiological Science, Division of MR Research, Johns Hopkins University, Baltimore, MD, USA; 2 Cellular Imaging Section, Vascular Biology Program, Institute for Cell Engineerin, Johns Hopkins University, Baltimore, MD, USA; 3 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; 4 Biogen-IDEC, Cambridge, MA, USA; 5 Neurology, Johns Hopkins University, Baltimore, MD, USA 16:36 664. In Vivo Magnetic Resonance Imaging of Ferritin-Based Reporter Visualizes Native Neuroblast Migration Bistra Iordanova 1,2 , Eric T. Ahrens 1,3 1 Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA; 2 Pittsburgh NMR Center for Biomedical Research , Pittsburgh, PA, USA; 3 Pittsburgh NMR Center for Biomedical Research, Pittsburgh, PA, USA 16:48 665. In Vivo Visualization of Pancreatic Islets in the Mouse David Z. Balla 1 , Sven Gottschalk 1 , G Shajan 1 , Sandra Ueberberg 2 , Stephan Schneider 2 , Rolf Pohmann 1 , Jörn Engelmann 1 1 High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; 2 Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany 17:00 666. Monitoring of Transplanted Pancreatic Islets in Humans By MRI Daniel Jirak 1 , Frantisek Saudek 2 , Monika Dezortova 1 , Peter Girman 2 , Vit Herynek 1 , Jan Kriz 2 , Zuzana Berkova 2 , Klara Zacharovova 2 , Jan Peregrin 1 , Milan Hajek 1 1 Department of Diagnostic & Interventional Radiology, Institute for Clinical & Experimental Medicine, Prague, Czech Republic; 2 Diabetes Center, Institute for Clinical & Experimental Medicine, Prague, Czech Republic 17:12 667. Divalent Metal Transporter, DMT1: A Novel MRI Reporter Benjamin Bay Bartelle 1 , Kamila Urzula Szulc 2 , Daniel H. Turnbull 2,3 1 Structural Biology, Skirball Institute for Biomolecular Medicine, New York, NY, USA; 2 Skirball Institute of Biomolecular Medicine; 3 Radiology, New York University School of Medicine 92
Thursday PM 17:24 668. Electron Paramagnetic Resonance as a New Sensitive Tool to Assess the Iron Content in Cells & Tissues For MRI Cell Labeling Studies Pierre Danhier 1 , Geraldine Depraeter 1 , Sebastien Boutry 2 , Isabelle Mahieu 2 , Robert N. Muller 2 , Pierre Sonveaux 3 , Caroline Bouzin 3 , Olivier Feron 3 , Philippe Leveque 1 , Julie Magat 1 , Benedicte Jordan 1 , Bernard Gallez 1 1 Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium; 2 University of Mons, Mons, Belgium; 3 Institute of Experimental & Clinical Research, University of Louvain, Brussels, Belgium 17:36 669. In Vivo Monitoring of Anti-Inflammatory Atorvastatin-Effects in Reperfused Myocardial Infarction using Integrated Cellular Fluorine 19 F-MRI & 1 H-Cardiac MRI Yu-Xiang Ye 1 , Thomas Christian Basse-Luesebrink 1 , Paula Arias 2 , Thomas Kampf 1 , Vladimir Kocoski 3 , Elisabeth Bauer 2 , Kai Hu 2 , Valerie Jahns 4 , Peter M. Jakob 1,5 , Karl-Heinz Hiller 1,5 , Roland Jahns 2 , Wolfgang Rudolf Bauer 2 1 Department for Experimental Physics 5, University of Würzburg, Würzburg, Bavaria, Germany; 2 Department of Internal Medicine I, University Hospital Würzburg; 3 Institute for Virology & Immunobiology; 4 Institute for Pharmacology & Toxicology, University of Würzburg; 5 MRB Research Center, Magnetic Resonance Bavaria 17:48 670. In Vivo MRI Signal Features of Transgenic Grafts Overexpressing Ferritin in the Murine Myocardial Infarction Model Anna Naumova 1,2 , Vasily Yarnykh 1,2 , Hans Reinecke 2,3 , Charles Murry 2,3 , Chun Yuan 1,2 1 Radiology, University of Washington, Seattle, WA, USA; 2 Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA; 3 Pathology, University of Washington, Seattle, WA, USA Tractography Room 710A 16:00-18:00 Moderators: Jonathan D. Clayden & Derek K. Jones 16:00 671. Tensor Based Morphometry of White Matter Tracts using Fibre Orientation Distributions David Raffelt 1,2 , Olivier Salvado 1 , Stephen Rose 3 , Robert Henderson 4 , Alan Connelly 5,6 , Stuart Crozier 2 , J.-Donald Tournier 5,6 1 The Australian E-Health Research Centre, CSIRO, Brisbane, QLD, Australia; 2 Biomedical Engineering, School of ITEE, University of Queensland, Brisbane, QLD, Australia; 3 Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia; 4 Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia; 5 Brain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, VIC, Australia; 6 Department of Medicine, University of Melbourne, Melbourne, VIC, Australia 16:12 672. The fiber Pathways of the Brain Organized As a Highly Curved Woven Grid Van Wedeen 1 , Douglas Rosene 2 , Guangping Dai 1 , Ruopeng Wang 1 , Jon Kaas 3 , Isaac Tseng 4 1 Radiology, Martinos Center/ MGH, Charlestown, MA, USA; 2 Anatomy & Neurobiology, Boston University Medical, Boston, MA, USA; 3 Cell & Developmental Biology, Vanderbilt University, Nashville, TN, USA; 4 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan 16:24 673. A Novel Paradigm For Automated Segmentation of Very Large Whole-Brain Probabilistic Tractography Data Sets Robert Elton Smith 1,2 , Jacques-Donald Tournier 1,2 , Fernando Calamante 1,2 , Alan Connelly 1,2 1 Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; 2 Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia 16:36 674. A Study of Effect of Compiling Method on Interregional Connectivity Maps of Brain Networks via Diffusion Tractography Longchuan Li 1 , James Rilling 2 , Todd Preuss 3 , Frederick Damen 4 , Xiaoping Hu 4 1 School of Medicine, Emory University/Georiga Institute of Technology, Atlanta, GA, USA; 2 Division of Psychobiology, Yerkes National Primate Research Center, Atlanta, GA, USA; 3 Division of Neuroscience, Yerkes National Primate Research Center, Atlanta, GA, USA; 4 Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA 16:48 675. Inter-Subject Variability of Structural Network: A DTI Study Hu Cheng 1 , Jinhua Sheng 2 , Yang Wang 2 , Olaf Sporns 1 , Andrew Saykin 2 , William Kronenberger 2 , Vincent Mathews 2 , Thomas Hummer 2 1 Indiana University, Bloomington, IN, USA; 2 Indiana University, Indianapolis, IN, USA 17:00 676. Mapping Hubs in the Neocortical Structural Network of the Human Brain Shows Lateralization Emil Harald Jeroen Nijhuis 1,2 , Anne-Marie van Cappellen van Walsum 2,3 , David G. Norris 1,4 1 Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; 2 MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Netherlands; 3 Department of Anatomy, Radboud University Nijmegen Medical Center, Netherlands; 4 Erwin L Hahn Institute for MRI, Universität Duisburg-Essen, Germany 93
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